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Phenotypic Abnormality (PA): Puberty and gonadal disorders

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the endocrine system [HP:0000818] <16>(30|34) (35|12|5)
0:   Puberty and gonadal disorders [HP:0008373] <13>(17|18) (20|3|1)
- 1:   Hypogonadism [HP:0000135] <4>(6|5) (7|3|1)
- 1:   Abnormal circulating estrogen level [HP:0025132] <3>(0|0) (1|0|0)
- 1:   Abnormal circulating progesterone level [HP:0031212] <3>(1|1) (1|0|0)
- 1:   Delayed puberty [HP:0000823] <3>(0|0) (0|0|0)
- 1:   Abnormal serum testosterone level [HP:0030087] <2>(0|0) (0|0|0)
- 1:   Early onset of sexual maturation [HP:0100000] <2>(2|2) (2|0|0)
- 1:   Menstrual irregularities [HP:0000858] <2>(6|8) (7|0|0)
- 1:   Absence of pubertal development [HP:0008197] <1>(1|1) (1|0|0)
- 1:   Absence of secondary sex characteristics [HP:0008187](0|0) (0|0|0)
- 1:   Adrenogenital syndrome [HP:0000840](1|1) (1|0|0)
- 1:   Androgen insufficiency [HP:0008226](0|0) (0|0|0)
- 1:   Leydig cell insensitivity to gonadotropin [HP:0002929](0|0) (0|0|0)
- 1:   Primary gonadal insufficiency [HP:0008193](1|1) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Restriction endonuclease-like0Direct
GAF domain-like0.005105Inherited
RuvA domain 2-like0.005105Inherited
NagB/RpiA/CoA transferase-like0.009814Inherited
SET domain0.0118Inherited
HD-domain/PDEase-like0.09471Inherited
RING/U-box0.1122Inherited
HMG-box0.1164Inherited
Fibrinogen C-terminal domain-like0.2098Inherited
Ribonuclease H-like0.2827Inherited
Family A G protein-coupled receptor-like0.3295Inherited
Cytochrome P4500.3663Inherited
Nuclear receptor ligand-binding domain0.4034Inherited
Trypsin-like serine proteases0.7436Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Smc hinge domain0Direct
IF2B-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
Fibrinogen coiled-coil and central regions0Direct
DNA polymerase I0.000705Direct
PDEase0.001848Inherited
GAF domain0.003531Inherited
Histone lysine methyltransferases0.007729Inherited
G proteins0.009788Inherited
Ngr ectodomain-like0.09617Inherited
HMG-box0.09617Inherited
Fibrinogen C-terminal domain-like0.1814Inherited
Rhodopsin-like0.358Inherited
Nuclear receptor ligand-binding domain0.3706Inherited
Cytochrome P4500.4322Inherited
Nuclear receptor0.4472Inherited
Eukaryotic proteases0.7117Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Restriction endonuclease-like0Direct
Fibrinogen coiled-coil and central regions0Direct
GAF domain-like0.003156Inherited
RuvA domain 2-like0.003156Inherited
NagB/RpiA/CoA transferase-like0.006393Inherited
SET domain0.007783Inherited
HD-domain/PDEase-like0.07448Inherited
RING/U-box0.0893Inherited
HMG-box0.093Inherited
DNA/RNA polymerases0.1158Inherited
Fibrinogen C-terminal domain-like0.1769Inherited
Ribonuclease H-like0.2451Inherited
Cystine-knot cytokines0.2621Inherited
Family A G protein-coupled receptor-like0.29Inherited
Cytochrome P4500.3249Inherited
Nuclear receptor ligand-binding domain0.3613Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3935Inherited
Trypsin-like serine proteases0.707Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.003156Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.003156Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.003156Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)