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Phenotypic Abnormality (PA): Abnormal glucose homeostasis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(76|83) (79|38|16)
+ 1:   Abnormal homeostasis [HP:0012337] <8>(42|43) (42|21|8)
0:   Abnormal glucose homeostasis [HP:0011014] <7>(10|11) (11|7|4)
- 1:   Abnormal blood glucose concentration [HP:0011015] <2>(7|7) (7|3|1)
- 1:   Glucose intolerance [HP:0001952] <2>(3|3) (4|3|3)
- 1:   Hyperinsulinemia [HP:0000842] <2>(0|0) (0|0|0)
- 1:   Insulin resistance [HP:0000855] <1>(0|1) (0|0|0)
- 1:   Impaired gluconeogenesis [HP:0005959](0|0) (0|0|0)
- 1:   Increased proinsulin:insulin ratio [HP:0031883](0|0) (0|0|0)
- 1:   Insulin insensitivity [HP:0008189](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
HD-domain/PDEase-like0.0003105Direct
GAF domain-like0.003385Inherited
Rudiment single hybrid motif0.003385Inherited
4Fe-4S ferredoxins0.003385Inherited
Insulin-like0.003385Inherited
Ribonuclease H-like0.01023Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.05822Inherited
Acyl-CoA dehydrogenase NM domain-like0.05822Inherited
Thiolase-like0.1106Inherited
Single hybrid motif0.1527Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
PDEase0.000995Direct
BC C-terminal domain-like0.002301Inherited
GAF domain0.002301Inherited
Insulin-like0.002301Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.002301Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.04651Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.04651Inherited
Phosphotyrosine-binding domain (PTB)0.06501Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1301Inherited
BC ATP-binding domain-like0.2102Inherited
BC N-terminal domain-like0.2102Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
HD-domain/PDEase-like0.0001578Direct
GAF domain-like0.002021Inherited
Insulin-like0.002021Inherited
Rudiment single hybrid motif0.002021Inherited
4Fe-4S ferredoxins0.002021Inherited
Ribonuclease H-like0.006656Inherited
Acyl-CoA dehydrogenase NM domain-like0.04392Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.04392Inherited
Thiolase-like0.08796Inherited
Single hybrid motif0.1255Inherited
Homeodomain-like0.1397Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.002021Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.002021Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.002021Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.002021Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.04392Inherited
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0.08796Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.002021Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.002021Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.003755Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.007693Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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