SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormal cardiovascular system physiology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the cardiovascular system [HP:0001626] <5>(59|81) (72|39|29)
0:   Abnormal cardiovascular system physiology [HP:0011025] <16>(21|32) (30|17|14)
- 1:   Abnormal cardiac ventricular function [HP:0030872] <6>(3|2) (3|0|0)
- 1:   Abnormal heart sound [HP:0031657] <5>(1|1) (2|0|0)
- 1:   Abnormal vascular physiology [HP:0030163] <5>(1|1) (1|0|1)
- 1:   Abnormal systemic blood pressure [HP:0030972] <4>(3|4) (3|3|5)
- 1:   Shock [HP:0031273] <4>(0|0) (0|0|0)
- 1:   Syncope [HP:0001279] <4>(1|3) (2|0|0)
- 1:   Abnormal heart valve physiology [HP:0031653] <3>(4|6) (5|7|10)
- 1:   Abnormality of blood circulation [HP:0011028] <3>(7|11) (12|3|1)
- 1:   Abnormality of cardiovascular system electrophysiology [HP:0030956] <3>(5|12) (8|5|2)
- 1:   Abnormal cardiac atrial physiology [HP:0025443] <2>(0|0) (0|0|0)
- 1:   Abnormal echocardiogram [HP:0003116] <2>(0|0) (0|0|0)
- 1:   Congestive heart failure [HP:0001635] <2>(0|0) (0|0|0)
- 1:   Reduced systolic function [HP:0006673] <2>(0|0) (0|0|0)
- 1:   Angina pectoris [HP:0001681](0|0) (0|0|0)
- 1:   Myocardial infarction [HP:0001658](0|0) (0|0|0)
- 1:   Presyncope [HP:0031972](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
GLA-domain0Direct
Notch domain0Direct
Fibrinogen coiled-coil and central regions0Direct
DPP6 N-terminal domain-like0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
SMAD MH1 domain0.01081Inherited
Fibrinogen C-terminal domain-like0.08704Inherited
Myosin rod fragments0.08704Inherited
MIR domain0.1164Inherited
Glycosyl hydrolase domain0.1276Inherited
Voltage-gated potassium channels0.1383Inherited
Spectrin repeat0.2048Inherited
Integrin domains0.2573Inherited
Trypsin-like serine proteases0.2621Inherited
Snake toxin-like0.3081Inherited
TB module/8-cys domain0.3597Inherited
Cadherin-like0.3965Inherited
L domain-like0.4908Inherited
Growth factor receptor domain0.6274Inherited
cAMP-binding domain-like0.6676Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Plakin repeat0Direct
Fibrinogen coiled-coil and central regions0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
GLA-domain0Direct
Notch domain0Direct
SMAD domain0.00794Inherited
DNA gyrase/MutL, second domain0.00794Inherited
DNA gyrase/MutL, N-terminal domain0.00794Inherited
SMAD MH1 domain0.00794Inherited
Cytoplasmic domain of inward rectifier potassium channel0.01075Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0223Inherited
NADPH-cytochrome p450 reductase-like0.0223Inherited
Calponin-homology domain, CH-domain0.03693Inherited
LIM domain0.0615Inherited
Myosin rod fragments0.07556Inherited
Fibrinogen C-terminal domain-like0.07556Inherited
MIR domain0.09998Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.1122Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.1122Inherited
Eukaryotic proteases0.1135Inherited
ZZ domain0.1582Inherited
Erythroid transcription factor GATA-10.1633Inherited
Spectrin repeat0.1883Inherited
Integrin domains0.2352Inherited
V set domains (antibody variable domain-like)0.2441Inherited
Voltage-gated potassium channels0.286Inherited
Calmodulin-like0.2945Inherited
EGF-type module0.2969Inherited
TB module/8-cys domain0.3343Inherited
Ngr ectodomain-like0.3628Inherited
Cadherin0.4018Inherited
Second domain of FERM0.7305Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Tricorn protease domain 20Direct
DPP6 N-terminal domain-like0Direct
GLA-domain0Direct
Plakin repeat0Direct
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
SMAD MH1 domain0.007084Inherited
Calponin-homology domain, CH-domain0.03182Inherited
Fibrinogen C-terminal domain-like0.06787Inherited
Myosin rod fragments0.06787Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07852Inherited
MIR domain0.09295Inherited
Glycosyl hydrolase domain0.1029Inherited
Acyl-CoA dehydrogenase NM domain-like0.1029Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1029Inherited
Voltage-gated potassium channels0.1128Inherited
Spectrin repeat0.1725Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.221Inherited
Integrin domains0.221Inherited
Trypsin-like serine proteases0.2257Inherited
Complement control module/SCR domain0.259Inherited
Snake toxin-like0.2694Inherited
TB module/8-cys domain0.3186Inherited
Cadherin-like0.3545Inherited
L domain-like0.4473Inherited
Immunoglobulin0.485Inherited
Cystine-knot cytokines0.5431Inherited
Growth factor receptor domain0.5877Inherited
cAMP-binding domain-like0.6287Inherited
Second domain of FERM0.783Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.007084Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.007339Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.0093Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1029Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1029Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1406Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1959Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2309Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.259Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.3186Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.3186Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3973Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.4831Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.05761Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.05761Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.06859Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.06859Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1517Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3052Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.3186Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3186Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)