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Phenotypic Abnormality (PA): Abnormal cardiovascular system physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
0:   Abnormal cardiovascular system physiology [HP:0011025] <16>(21|34) (29|18|16)
- 1:   Abnormal cardiac ventricular function [HP:0030872] <6>(3|2) (3|0|0)
- 1:   Abnormal heart sound [HP:0031657] <5>(0|1) (2|0|0)
- 1:   Abnormal vascular physiology [HP:0030163] <5>(1|1) (1|0|1)
- 1:   Abnormal systemic blood pressure [HP:0030972] <4>(3|4) (3|3|5)
- 1:   Shock [HP:0031273] <4>(0|0) (0|0|0)
- 1:   Syncope [HP:0001279] <4>(1|2) (2|0|0)
- 1:   Abnormal heart valve physiology [HP:0031653] <3>(4|7) (5|7|11)
- 1:   Abnormality of blood circulation [HP:0011028] <3>(7|11) (11|3|1)
- 1:   Abnormality of cardiovascular system electrophysiology [HP:0030956] <3>(5|12) (8|5|2)
- 1:   Abnormal cardiac atrial physiology [HP:0025443] <2>(0|0) (0|0|0)
- 1:   Abnormal echocardiogram [HP:0003116] <2>(0|0) (0|0|0)
- 1:   Congestive heart failure [HP:0001635] <2>(0|0) (0|0|0)
- 1:   Reduced systolic function [HP:0006673] <2>(0|0) (0|0|0)
- 1:   Angina pectoris [HP:0001681](0|0) (0|0|0)
- 1:   Myocardial infarction [HP:0001658](0|0) (0|0|0)
- 1:   Presyncope [HP:0031972](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Tricorn protease domain 20Direct
DPP6 N-terminal domain-like0Direct
Plakin repeat0Direct
GLA-domain0Direct
Fibrinogen coiled-coil and central regions0Direct
SMAD MH1 domain0.01131Inherited
Fibrinogen C-terminal domain-like0.02889Inherited
MIR domain0.1179Inherited
Glycosyl hydrolase domain0.1291Inherited
Voltage-gated potassium channels0.1806Inherited
Myosin rod fragments0.1843Inherited
Spectrin repeat0.2075Inherited
Trypsin-like serine proteases0.2193Inherited
Cadherin-like0.2573Inherited
Integrin domains0.2603Inherited
Snake toxin-like0.3123Inherited
TB module/8-cys domain0.3631Inherited
L domain-like0.3892Inherited
Growth factor receptor domain0.6374Inherited
cAMP-binding domain-like0.6722Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
GLA-domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Notch domain0Direct
Plakin repeat0Direct
Multidomain cupredoxins0Direct
Fibrinogen coiled-coil and central regions0Direct
DNA gyrase/MutL, second domain0.008326Inherited
SMAD MH1 domain0.008326Inherited
SMAD domain0.008326Inherited
DNA gyrase/MutL, N-terminal domain0.008326Inherited
Cytoplasmic domain of inward rectifier potassium channel0.0114Inherited
NADPH-cytochrome p450 reductase-like0.02314Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02314Inherited
Fibrinogen C-terminal domain-like0.02341Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.02449Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.02449Inherited
Calponin-homology domain, CH-domain0.03812Inherited
LIM domain0.06428Inherited
Eukaryotic proteases0.08874Inherited
MIR domain0.1016Inherited
ZZ domain0.1604Inherited
Myosin rod fragments0.166Inherited
Erythroid transcription factor GATA-10.166Inherited
Spectrin repeat0.1918Inherited
Integrin domains0.2387Inherited
Cadherin0.2489Inherited
V set domains (antibody variable domain-like)0.2522Inherited
EGF-type module0.3049Inherited
Voltage-gated potassium channels0.3051Inherited
G proteins0.3186Inherited
TB module/8-cys domain0.3384Inherited
Ngr ectodomain-like0.3753Inherited
Calmodulin-like0.4127Inherited
Second domain of FERM0.7391Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GLA-domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
DPP6 N-terminal domain-like0Direct
SMAD MH1 domain0.007325Inherited
Fibrinogen C-terminal domain-like0.0202Inherited
Acyl-CoA dehydrogenase NM domain-like0.02159Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.02159Inherited
Calponin-homology domain, CH-domain0.03232Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.08023Inherited
MIR domain0.09378Inherited
Glycosyl hydrolase domain0.1039Inherited
Voltage-gated potassium channels0.1495Inherited
Myosin rod fragments0.1527Inherited
Spectrin repeat0.1742Inherited
Trypsin-like serine proteases0.185Inherited
Cadherin-like0.22Inherited
Integrin domains0.2227Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2227Inherited
Snake toxin-like0.2717Inherited
TB module/8-cys domain0.3207Inherited
L domain-like0.346Inherited
Immunoglobulin0.4166Inherited
Cystine-knot cytokines0.5526Inherited
Growth factor receptor domain0.5962Inherited
cAMP-binding domain-like0.6321Inherited
Second domain of FERM0.7892Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.007325Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.007506Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.009676Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.02159Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1039Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1419Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1976Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2334Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2621Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.3207Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.3207Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.5218Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.6277Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.05788Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.05788Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.06932Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.06932Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1527Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.2227Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3081Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.3207Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3207Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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