SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of skin morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the integument [HP:0001574] <4>(46|69) (58|36|15)
+ 1:   Abnormality of the skin [HP:0000951] <4>(33|53) (45|35|12)
0:   Abnormality of skin morphology [HP:0011121] <22>(28|47) (40|30|11)
- 1:   Localized skin lesion [HP:0011355] <29>(12|20) (18|10|6)
- 1:   Abnormality of skin pigmentation [HP:0001000] <17>(2|8) (4|2|0)
- 1:   Generalized abnormality of skin [HP:0011354] <12>(7|11) (11|4|1)
- 1:   Regional abnormality of skin [HP:0011356] <11>(7|9) (9|5|1)
- 1:   Abnormality of epidermal morphology [HP:0011124] <5>(1|1) (1|1|0)
- 1:   Abnormal blistering of the skin [HP:0008066] <4>(3|2) (3|3|1)
- 1:   Abnormal cutaneous elastic fiber morphology [HP:0025082] <4>(0|0) (0|0|0)
- 1:   Abnormal dermoepidermal junction morphology [HP:0031538] <4>(0|0) (0|0|0)
- 1:   Thickened skin [HP:0001072] <4>(3|6) (4|5|2)
- 1:   Abnormal elasticity of skin [HP:0010647] <3>(0|2) (0|1|0)
- 1:   Abnormal cutaneous collagen fibril morphology [HP:0031512] <2>(0|0) (0|0|0)
- 1:   Lichenification [HP:0100725] <1>(1|0) (1|0|0)
- 1:   Pallor [HP:0000980] <1>(1|1) (1|0|0)
- 1:   Dermal translucency [HP:0010648](0|0) (0|0|0)
- 1:   Dry skin [HP:0000958](0|0) (0|0|0)
- 1:   Elevated dermal desmosine content [HP:0025083](0|0) (0|0|0)
- 1:   Flaky paint dermatosis [HP:0032178](0|0) (0|0|0)
- 1:   Keratosis pilaris [HP:0032152](1|1) (1|0|0)
- 1:   Maceration [HP:0032007](0|0) (0|0|0)
- 1:   Ochronosis [HP:0030764](0|0) (0|0|0)
- 1:   Poikiloderma [HP:0001029](0|0) (0|0|0)
- 1:   Stiff skin [HP:0030053](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Notch domain0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
RuvA domain 2-like0Direct
Zn-finger domain of Sec23/240Direct
Integrin beta tail domain0Direct
SAND domain-like0Direct
Apolipoprotein A-I0Direct
ABC transporter transmembrane region0.002322Inherited
Intermediate filament protein, coiled coil region0.008512Inherited
DNA/RNA polymerases0.0111Inherited
Integrin domains0.02005Inherited
Spectrin repeat0.02203Inherited
Globin-like0.02247Inherited
EGF/Laminin0.02619Inherited
Prefoldin0.06465Inherited
ARID-like0.1117Inherited
Nicotinic receptor ligand binding domain-like0.1705Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1705Inherited
FnI-like domain0.3206Inherited
Complement control module/SCR domain0.562Inherited
(Trans)glycosidases0.5904Inherited
Bromodomain0.6187Inherited
RNI-like0.6827Inherited
Immunoglobulin0.9611Inherited
alpha/beta-Hydrolases0.979Inherited
DEATH domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Plakin repeat0Direct
Proteasome subunits0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Integrin beta tail domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
ets domain0Direct
Apolipoprotein A-I0Direct
Histone deacetylase, HDAC0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Integrin beta EGF-like domains0Direct
Zn-finger domain of Sec23/240Direct
Notch domain0Direct
Integrin A (or I) domain0.0002Direct
Intermediate filament protein, coiled coil region0.007345Inherited
GLA-domain0.008327Inherited
Integrin domains0.01585Inherited
DnaQ-like 3'-5' exonuclease0.01741Inherited
Globins0.01741Inherited
Spectrin repeat0.01817Inherited
EGF-type module0.03385Inherited
beta-sandwich domain of Sec23/240.07061Inherited
C-terminal, gelsolin-like domain of Sec23/240.07061Inherited
Trunk domain of Sec23/240.07061Inherited
Helical domain of Sec23/240.07061Inherited
Ras-binding domain, RBD0.09655Inherited
ARID domain0.09655Inherited
Histone lysine methyltransferases0.116Inherited
Nicotinic receptor ligand binding domain-like0.1573Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1573Inherited
Laminin-type module0.1738Inherited
VWC domain0.1778Inherited
G proteins0.2333Inherited
RecA protein-like (ATPase-domain)0.2588Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2697Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.395Inherited
Complement control module/SCR domain0.5206Inherited
Tyrosine-dependent oxidoreductases0.5206Inherited
PHD domain0.5206Inherited
Bromodomain0.5809Inherited
DEATH domain, DD0.6485Inherited
Erythroid transcription factor GATA-10.6854Inherited
Ngr ectodomain-like0.8004Inherited
V set domains (antibody variable domain-like)0.9074Inherited
MHC antigen-recognition domain0.912Inherited
TNF receptor-like0.9507Inherited
C1 set domains (antibody constant domain-like)1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
Tricorn protease domain 20Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Plakin repeat0Direct
Apolipoprotein A-I0Direct
RuvA domain 2-like0Direct
Integrin beta tail domain0Direct
Zn-finger domain of Sec23/240Direct
Notch domain0Direct
ABC transporter transmembrane region0.001341Inherited
vWA-like0.00265Inherited
Intermediate filament protein, coiled coil region0.005497Inherited
GLA-domain0.007289Inherited
DNA/RNA polymerases0.007289Inherited
Integrin domains0.01377Inherited
Spectrin repeat0.01525Inherited
Globin-like0.01558Inherited
EGF/Laminin0.0183Inherited
Prefoldin0.0492Inherited
C-terminal, gelsolin-like domain of Sec23/240.06506Inherited
Helical domain of Sec23/240.06506Inherited
ARID-like0.08885Inherited
Nicotinic receptor ligand binding domain-like0.141Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.141Inherited
SET domain0.1466Inherited
4-helical cytokines0.2291Inherited
FnI-like domain0.2813Inherited
Adenine nucleotide alpha hydrolases-like0.3742Inherited
Protein kinase-like (PK-like)0.4593Inherited
Complement control module/SCR domain0.5197Inherited
Nucleotide-diphospho-sugar transferases0.5197Inherited
(Trans)glycosidases0.5486Inherited
Bromodomain0.5788Inherited
P-loop containing nucleoside triphosphate hydrolases0.6441Inherited
RNI-like0.6444Inherited
MHC antigen-recognition domain0.9013Inherited
L domain-like0.934Inherited
Immunoglobulin0.9365Inherited
alpha/beta-Hydrolases0.9564Inherited
DEATH domain0.9978Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001341Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.01907Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.032Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.032Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04248Inherited
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.06506Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.06519Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.08885Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.09837Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.141Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.443Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.5486Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.9013Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.9207Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.9912Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003374Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.03394Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1006Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1345Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2531Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)