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Phenotypic Abnormality (PA): Epidermal thickening

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Phenotypic abnormality [HP:0000118] <25>
+ + + + 4:   Abnormality of the integument [HP:0001574] <4>(48|69) (59|37|15)
+ + + 3:   Abnormality of the skin [HP:0000951] <4>(34|55) (45|36|12)
+ + 2:   Abnormality of skin morphology [HP:0011121] <22>(29|49) (40|31|11)
+ 1:   Thickened skin [HP:0001072] <4>(3|6) (3|6|2)
0:   Epidermal thickening [HP:0011368] <9>(3|6) (3|6|2)
- 1:   Hyperkeratosis [HP:0000962] <21>(2|5) (2|6|2)
- 1:   Ichthyosis [HP:0008064] <5>(1|1) (2|1|0)
- 1:   Parakeratosis [HP:0001036] <1>(0|0) (0|0|0)
- 1:   Acanthosis nigricans [HP:0000956](0|0) (0|0|0)
- 1:   Acrokeratosis [HP:0200016](0|0) (0|0|0)
- 1:   Generalized keratosis follicularis [HP:0007439](0|0) (0|0|0)
- 1:   Hypergranulosis [HP:0025114](0|0) (0|0|0)
- 1:   Orthokeratosis [HP:0040162](0|0) (0|0|0)
- 1:   Porokeratosis [HP:0200044](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Intermediate filament protein, coiled coil region0.00000000123Direct
Spectrin repeat0.0003279Direct
Prefoldin0.01907Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Intermediate filament protein, coiled coil region0.0000000006815Direct
Spectrin repeat0.0001904Direct
Ras-binding domain, RBD0.004464Inherited
Laminin-type module0.01496Inherited
Tyrosine-dependent oxidoreductases0.01715Inherited
Integrin A (or I) domain0.3998Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Intermediate filament protein, coiled coil region0.0000000004684Direct
Spectrin repeat0.0001622Direct
Prefoldin0.01289Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0Direct
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.00007357Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.0004693Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.001785Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.9836Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.001456Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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