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Phenotypic Abnormality (PA): Abnormality of central motor function

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(101|119) (112|81|39)
0:   Abnormality of central motor function [HP:0011442] <10>(22|26) (30|16|7)
- 1:   Abnormality of extrapyramidal motor function [HP:0002071] <7>(1|1) (1|1|0)
- 1:   Apraxia [HP:0002186] <6>(0|0) (1|0|0)
- 1:   Paralysis [HP:0003470] <6>(4|3) (4|0|0)
- 1:   Abnormality of coordination [HP:0011443] <5>(2|3) (7|5|2)
- 1:   Rigidity [HP:0002063] <4>(0|0) (0|1|0)
- 1:   Upper motor neuron dysfunction [HP:0002493] <4>(9|15) (13|8|4)
- 1:   Cerebral palsy [HP:0100021] <1>(1|1) (1|0|0)
- 1:   Torticollis [HP:0000473] <1>(1|1) (1|1|0)
- 1:   Abnormality of central motor conduction [HP:0012079](0|0) (0|0|0)
- 1:   Central hypotonia [HP:0011398](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Tricorn protease domain 20Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
HIT-like0Direct
Lamin A/C globular tail domain0Direct
ADC-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Ribonuclease PH domain 2-like0Direct
Periplasmic binding protein-like II0.0008298Direct
Periplasmic binding protein-like I0.007965Inherited
Cysteine proteinases0.01269Inherited
CRAL/TRIO domain0.08194Inherited
Translation proteins0.1304Inherited
Calcium-dependent phosphotriesterase0.1911Inherited
Voltage-gated potassium channels0.2246Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2505Inherited
Chaperone J-domain0.2921Inherited
RNA-binding domain, RBD0.4066Inherited
Integrin domains0.5858Inherited
vWA-like0.6488Inherited
Intermediate filament protein, coiled coil region0.9787Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Lamin A/C globular tail domain0Direct
Glycosyl transferases group 10Direct
Cytochrome b50Direct
Phosphate binding protein-like0Direct
CAT-like0Direct
L-aspartase/fumarase0Direct
Ribonuclease PH domain 1-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
UBA domain0Direct
Ribonuclease PH domain 2-like0Direct
IF2B-like0Direct
Extended AAA-ATPase domain0.009813Inherited
L-arabinose binding protein-like0.01548Inherited
DNA gyrase/MutL, second domain0.02576Inherited
DNA gyrase/MutL, N-terminal domain0.02576Inherited
MHC antigen-recognition domain0.04926Inherited
Elongation factors0.07231Inherited
Chaperone J-domain0.2394Inherited
Canonical RBD0.3158Inherited
Nucleotide and nucleoside kinases0.3546Inherited
Integrin domains0.5304Inherited
Integrin A (or I) domain0.5897Inherited
Intermediate filament protein, coiled coil region0.9603Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Tricorn protease domain 20Direct
Cytochrome b5-like heme/steroid binding domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
HIT-like0Direct
Lamin A/C globular tail domain0Direct
Ribonuclease PH domain 2-like0Direct
ADC-like0Direct
Periplasmic binding protein-like II0.0004336Direct
Periplasmic binding protein-like I0.005041Inherited
Class II aaRS and biotin synthetases0.007504Inherited
Cysteine proteinases0.008324Inherited
MHC antigen-recognition domain0.05335Inherited
CRAL/TRIO domain0.06329Inherited
Translation proteins0.105Inherited
HAD-like0.1249Inherited
Calcium-dependent phosphotriesterase0.1591Inherited
4Fe-4S ferredoxins0.1591Inherited
Voltage-gated potassium channels0.1899Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2138Inherited
Calcium ATPase, transduction domain A0.2455Inherited
Chaperone J-domain0.2527Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2658Inherited
Calcium ATPase, transmembrane domain M0.3086Inherited
RNA-binding domain, RBD0.3632Inherited
Integrin domains0.5429Inherited
vWA-like0.608Inherited
BRCT domain0.7588Inherited
Intermediate filament protein, coiled coil region0.956Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0149Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.02743Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.05335Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1417Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1995Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2138Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.2658Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2658Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6281Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.7522Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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