SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of central motor function

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
0:   Abnormality of central motor function [HP:0011442] <10>(18|24) (27|15|5)
- 1:   Abnormality of extrapyramidal motor function [HP:0002071] <7>(1|1) (1|1|0)
- 1:   Apraxia [HP:0002186] <6>(0|0) (1|0|0)
- 1:   Paralysis [HP:0003470] <6>(3|3) (3|0|0)
- 1:   Abnormality of coordination [HP:0011443] <5>(1|3) (6|5|2)
- 1:   Rigidity [HP:0002063] <4>(0|0) (0|1|0)
- 1:   Upper motor neuron dysfunction [HP:0002493] <4>(8|14) (13|7|3)
- 1:   Cerebral palsy [HP:0100021] <1>(1|1) (1|0|0)
- 1:   Torticollis [HP:0000473] <1>(1|1) (1|1|0)
- 1:   Abnormality of central motor conduction [HP:0012079](0|0) (0|0|0)
- 1:   Central hypotonia [HP:0011398](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
ThrRS/AlaRS common domain0Direct
ADC-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Ribonuclease PH domain 2-like0Direct
Tricorn protease domain 20Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
HIT-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Cysteine proteinases0.01833Inherited
Translation proteins0.1708Inherited
Calcium-dependent phosphotriesterase0.1896Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2478Inherited
Voltage-gated potassium channels0.2847Inherited
Chaperone J-domain0.2881Inherited
Integrin domains0.5778Inherited
vWA-like0.7177Inherited
Intermediate filament protein, coiled coil region0.9757Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
CAT-like0Direct
Glycosyl transferases group 10Direct
Lamin A/C globular tail domain0Direct
UBA domain0Direct
IF2B-like0Direct
Ribonuclease PH domain 1-like0Direct
L-aspartase/fumarase0Direct
Ribonuclease PH domain 2-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Extended AAA-ATPase domain0.009785Inherited
L-arabinose binding protein-like0.01463Inherited
DNA gyrase/MutL, second domain0.02495Inherited
DNA gyrase/MutL, N-terminal domain0.02495Inherited
MHC antigen-recognition domain0.04721Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2316Inherited
Chaperone J-domain0.2384Inherited
Canonical RBD0.2628Inherited
Nucleotide and nucleoside kinases0.3456Inherited
Integrin domains0.5218Inherited
Integrin A (or I) domain0.5792Inherited
Intermediate filament protein, coiled coil region0.9555Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
HIT-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ADC-like0Direct
Tricorn protease domain 20Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribonuclease PH domain 2-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Lamin A/C globular tail domain0Direct
ThrRS/AlaRS common domain0Direct
Cysteine proteinases0.01247Inherited
NagB/RpiA/CoA transferase-like0.04022Inherited
MHC antigen-recognition domain0.05154Inherited
HAD-like0.1195Inherited
Translation proteins0.1413Inherited
Ribonuclease H-like0.154Inherited
Calcium-dependent phosphotriesterase0.1585Inherited
4Fe-4S ferredoxins0.1585Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2119Inherited
Calcium ATPase, transduction domain A0.2386Inherited
Voltage-gated potassium channels0.2469Inherited
Chaperone J-domain0.2501Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.259Inherited
Calcium ATPase, transmembrane domain M0.3001Inherited
Integrin domains0.5357Inherited
vWA-like0.6801Inherited
BRCT domain0.7565Inherited
Intermediate filament protein, coiled coil region0.9526Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.02411Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.02667Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.05154Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1388Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.1641Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1945Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2119Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.259Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.259Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6211Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.7494Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)