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Phenotypic Abnormality (PA): Abnormality of higher mental function

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
0:   Abnormality of higher mental function [HP:0011446] <9>(38|46) (42|25|8)
- 1:   Neurological speech impairment [HP:0002167] <20>(5|9) (6|4|1)
- 1:   Reduced consciousness/confusion [HP:0004372] <11>(11|10) (14|3|1)
- 1:   Apraxia [HP:0002186] <6>(0|0) (1|0|0)
- 1:   Intellectual disability [HP:0001249] <6>(10|11) (10|5|2)
- 1:   Agnosia [HP:0010524] <4>(2|3) (2|1|0)
- 1:   Cognitive impairment [HP:0100543] <3>(4|4) (6|4|0)
- 1:   Language impairment [HP:0002463] <1>(0|0) (0|0|0)
- 1:   Micrographia [HP:0031908](0|0) (0|0|0)
- 1:   Optic ataxia [HP:0031868](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
LuxS/MPP-like metallohydrolase0Direct
Arginase/deacetylase0Direct
CRAL/TRIO domain0Direct
PP2C-like0Direct
SNARE fusion complex0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
BRK domain-like0Direct
L-aspartase-like0Direct
HIT-like0Direct
ADC-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
4Fe-4S ferredoxins0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Methylglyoxal synthase-like0Direct
Proton glutamate symport protein0Direct
Single hybrid motif0.01608Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.04006Inherited
Bromodomain0.04992Inherited
(Trans)glycosidases0.06894Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.121Inherited
Acyl-CoA dehydrogenase NM domain-like0.121Inherited
NagB/RpiA/CoA transferase-like0.1698Inherited
PreATP-grasp domain0.1851Inherited
Glycosyl hydrolase domain0.229Inherited
GST C-terminal domain-like0.2823Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2823Inherited
Mitochondrial carrier0.314Inherited
ClpP/crotonase0.3489Inherited
CoA-dependent acyltransferases0.3939Inherited
RNA-binding domain, RBD0.4681Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.656Inherited
Ribosomal protein S5 domain 2-like0.7098Inherited
Intermediate filament protein, coiled coil region0.8396Inherited
Adenine nucleotide alpha hydrolases-like0.9525Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Proton glutamate symport protein0Direct
Histone lysine methyltransferases0Direct
Ferredoxin domains from multidomain proteins0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Exostosin0Direct
beta-glycanases0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
L-aspartase/fumarase0Direct
Histone deacetylase, HDAC0Direct
BRK domain-like0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Glycosyl transferases group 10Direct
Amylase, catalytic domain0Direct
IF2B-like0Direct
MPP-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Lamin A/C globular tail domain0Direct
UBA domain0Direct
PP2C-like0Direct
SNARE fusion complex0Direct
Phosphate binding protein-like0Direct
PWWP domain0Direct
CUT domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
CAT-like0Direct
Extended AAA-ATPase domain0.0003666Direct
Biotinyl/lipoyl-carrier proteins and domains0.01053Inherited
Bromodomain0.0378Inherited
L-arabinose binding protein-like0.0394Inherited
BC ATP-binding domain-like0.0514Inherited
BC N-terminal domain-like0.0514Inherited
DNA gyrase/MutL, second domain0.08509Inherited
DNA gyrase/MutL, N-terminal domain0.08509Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.1556Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.1556Inherited
Mitochondrial carrier0.2697Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.289Inherited
Nicotinic receptor ligand binding domain-like0.289Inherited
Clathrin coat assembly domain0.3109Inherited
Canonical RBD0.4675Inherited
ABC transporter ATPase domain-like0.7172Inherited
Intermediate filament protein, coiled coil region0.805Inherited
Complement control module/SCR domain0.8585Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PP2C-like0Direct
CRAL/TRIO domain0Direct
ADC-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
4Fe-4S ferredoxins0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
BRK domain-like0Direct
L-aspartase-like0Direct
Lamin A/C globular tail domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
SNARE fusion complex0Direct
LuxS/MPP-like metallohydrolase0Direct
Methylglyoxal synthase-like0Direct
HIT-like0Direct
Arginase/deacetylase0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Proton glutamate symport protein0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Single hybrid motif0.01085Inherited
Periplasmic binding protein-like I0.01775Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.02908Inherited
Bromodomain0.03719Inherited
(Trans)glycosidases0.05276Inherited
Acyl-CoA dehydrogenase NM domain-like0.09703Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.09703Inherited
NagB/RpiA/CoA transferase-like0.1404Inherited
PreATP-grasp domain0.1543Inherited
Glycosyl hydrolase domain0.1945Inherited
GST C-terminal domain-like0.2449Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2449Inherited
Mitochondrial carrier0.275Inherited
Nicotinic receptor ligand binding domain-like0.2868Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2868Inherited
Glutathione synthetase ATP-binding domain-like0.2952Inherited
ClpP/crotonase0.3083Inherited
CoA-dependent acyltransferases0.352Inherited
RNA-binding domain, RBD0.4249Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.6169Inherited
Ribosomal protein S5 domain 2-like0.6719Inherited
Intermediate filament protein, coiled coil region0.8071Inherited
Adenine nucleotide alpha hydrolases-like0.9269Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.08567Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.09703Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.1409Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1945Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1945Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2868Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.352Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8164Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8716Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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