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Phenotypic Abnormality (PA): Abnormality of the anterior pituitary

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ + + + 4:   Abnormality of nervous system morphology [HP:0012639] <5>(70|97) (81|48|16)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the endocrine system [HP:0000818] <16>(30|34) (35|12|5)
+ + + 3:   Morphological abnormality of the central nervous system [HP:0002011] <17>(61|85) (71|41|16)
+ + 2:   Abnormality of brain morphology [HP:0012443] <13>(44|63) (54|31|14)
+ + 2:   Abnormality of the hypothalamus-pituitary axis [HP:0000864] <2>(6|8) (7|2|0)
+ 1:   Abnormality of the pituitary gland [HP:0012503] <5>(6|8) (7|2|0)
0:   Abnormality of the anterior pituitary [HP:0011747] <7>(6|8) (7|2|0)
- 1:   Hyperpituitarism [HP:0010514] <4>(2|4) (2|0|0)
- 1:   Neoplasm of the anterior pituitary [HP:0011750] <3>(2|2) (2|1|0)
- 1:   Anterior pituitary dysgenesis [HP:0010625] <2>(1|1) (1|1|0)
- 1:   Hypopituitarism [HP:0040075] <1>(2|1) (2|0|0)
- 1:   Ectopic anterior pituitary gland [HP:0012731](1|1) (1|0|0)
- 1:   Pituitary calcification [HP:0010513](0|0) (0|0|0)
- 1:   Pituitary resistance to thyroid hormone [HP:0008227](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.001586Inherited
p53-like transcription factors0.001847Inherited
Ribosomal protein S5 domain 2-like0.01446Inherited
Cytochrome P4500.1355Inherited
Nuclear receptor ligand-binding domain0.6905Inherited
Homeodomain-like0.7708Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA gyrase/MutL, second domain0.0000101Direct
DNA gyrase/MutL, N-terminal domain0.0000101Direct
HMG-box0.0008521Direct
Tyrosine-dependent oxidoreductases0.01866Inherited
Cytochrome P4500.1166Inherited
Homeodomain0.5026Inherited
Nuclear receptor ligand-binding domain0.6918Inherited
Nuclear receptor0.731Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
HMG-box0.0005711Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0008901Direct
p53-like transcription factors0.001047Inherited
Ribosomal protein S5 domain 2-like0.009686Inherited
Cytochrome P4500.1101Inherited
Nuclear receptor ligand-binding domain0.6523Inherited
Homeodomain-like0.7352Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.000006586Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.02479Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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