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Phenotypic Abnormality (PA): Abnormality of skeletal physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the skeletal system [HP:0000924] <7>(89|98) (94|51|33)
0:   Abnormality of skeletal physiology [HP:0011843] <8>(16|23) (18|15|15)
- 1:   Abnormality of joint mobility [HP:0011729] <6>(15|21) (17|15|15)
- 1:   Increased susceptibility to fractures [HP:0002659] <5>(0|0) (0|0|0)
- 1:   Osteomyelitis [HP:0002754] <4>(0|0) (0|0|0)
- 1:   Abnormality of skeletal maturation [HP:0000927] <3>(2|3) (2|0|0)
- 1:   Limb pain [HP:0009763] <2>(0|0) (0|0|0)
- 1:   Avascular necrosis [HP:0010885] <1>(0|0) (0|0|0)
- 1:   Bone pain [HP:0002653](0|0) (0|0|0)
- 1:   Delayed fracture healing [HP:0032537](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TB module/8-cys domain0Direct
Ribonuclease PH domain 2-like0Direct
vWA-like0.0314Inherited
SET domain0.04204Inherited
Tropomyosin0.0472Inherited
Bromodomain0.06219Inherited
Histone-fold0.0947Inherited
ARID-like0.0947Inherited
Troponin coil-coiled subunits0.09687Inherited
C-terminal, gelsolin-like domain of Sec23/240.1533Inherited
BRK domain-like0.1533Inherited
Helical domain of Sec23/240.1533Inherited
MIR domain0.245Inherited
Cystine-knot cytokines0.2888Inherited
Spectrin repeat0.3054Inherited
Calponin-homology domain, CH-domain0.502Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Ribonuclease PH domain 1-like0Direct
Ribonuclease PH domain 2-like0Direct
TB module/8-cys domain0Direct
Integrin A (or I) domain0.006967Inherited
DNA gyrase/MutL, second domain0.01189Inherited
DNA gyrase/MutL, N-terminal domain0.01189Inherited
VWC domain0.01658Inherited
Ras-binding domain, RBD0.03743Inherited
Tropomyosin0.03772Inherited
Bromodomain0.05431Inherited
ARID domain0.0814Inherited
beta-sandwich domain of Sec23/240.1347Inherited
C-terminal, gelsolin-like domain of Sec23/240.1347Inherited
TBP-associated factors, TAFs0.1347Inherited
Trunk domain of Sec23/240.1347Inherited
Helical domain of Sec23/240.1347Inherited
BRK domain-like0.1347Inherited
MIR domain0.2183Inherited
Spectrin repeat0.2892Inherited
Calponin-homology domain, CH-domain0.4903Inherited
PHD domain0.5759Inherited
Rhodopsin-like0.7583Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Ribonuclease PH domain 2-like0Direct
TB module/8-cys domain0Direct
vWA-like0.02236Inherited
SET domain0.03066Inherited
Tropomyosin0.03491Inherited
Bromodomain0.04721Inherited
Histone-fold0.07447Inherited
ARID-like0.07447Inherited
Troponin coil-coiled subunits0.07635Inherited
C-terminal, gelsolin-like domain of Sec23/240.126Inherited
BRK domain-like0.126Inherited
Helical domain of Sec23/240.126Inherited
MIR domain0.2096Inherited
Cystine-knot cytokines0.2509Inherited
Spectrin repeat0.2669Inherited
HLH, helix-loop-helix DNA-binding domain0.387Inherited
Calponin-homology domain, CH-domain0.4586Inherited
Family A G protein-coupled receptor-like0.6691Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.01106Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02667Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.02937Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.07447Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.126Inherited
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.126Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1799Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.1839Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.2469Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.402Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.08459Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.121Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1543Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1954Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)