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Phenotypic Abnormality (PA): Abnormal leukocyte count

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormal immune system morphology [HP:0032251] <3>(11|11) (11|6|2)
+ + 2:   Abnormality of blood and blood-forming tissues [HP:0001871] <11>(24|35) (31|16|5)
+ + 2:   Abnormal cellular immune system morphology [HP:0010987] <1>(10|10) (10|6|2)
+ 1:   Abnormal leukocyte morphology [HP:0001881] <4>(8|9) (9|5|2)
0:   Abnormal leukocyte count [HP:0011893] <7>(4|8) (6|5|2)
- 1:   Abnormal granulocyte count [HP:0032309] <5>(2|4) (4|3|2)
- 1:   Abnormal lymphocyte count [HP:0040088] <4>(0|1) (0|0|0)
- 1:   Abnormal monocyte count [HP:0012310] <2>(0|0) (0|0|0)
- 1:   Leukocytosis [HP:0001974] <2>(0|2) (1|1|0)
- 1:   Leukopenia [HP:0001882] <1>(3|5) (3|3|2)
- 1:   Abnormal dendritic cell count [HP:0020178](0|0) (0|0|0)
- 1:   Increased peripheral blast count [HP:0032372](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0.0003723Direct
STAT0.0003723Direct
RNI-like0.000394Direct
p53-like transcription factors0.2822Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Pyrin domain, PYD0.00004605Direct
Nitrogenase iron protein-like0.0002212Direct
Transcription factor STAT-4 N-domain0.0002212Direct
STAT DNA-binding domain0.0002212Direct
STAT0.0002212Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.003954Inherited
28-residue LRR0.004217Inherited
SH2 domain0.1292Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0.0001851Direct
STAT0.0001851Direct
RNI-like0.0001962Direct
SH2 domain0.1288Inherited
p53-like transcription factors0.2437Inherited
Immunoglobulin0.7742Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000176Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001851Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001851Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0001851Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001514Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001851Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001851Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)