SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormal respiratory system morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the respiratory system [HP:0002086] <3>(28|34) (37|24|20)
0:   Abnormal respiratory system morphology [HP:0012252] <5>(18|24) (25|18|17)
- 1:   Abnormal lung morphology [HP:0002088] <28>(10|17) (17|11|7)
- 1:   Abnormal sputum [HP:0032016] <3>(2|2) (4|1|0)
- 1:   Abnormal pulmonary situs morphology [HP:0011615] <2>(0|0) (0|0|0)
- 1:   Abnormal respiratory epithelium morphology [HP:0012253] <2>(0|0) (0|0|0)
- 1:   Abnormality of the upper respiratory tract [HP:0002087] <2>(8|9) (8|5|8)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Saposin0Direct
Tricorn protease domain 20Direct
DEATH domain0.004136Inherited
TB module/8-cys domain0.007229Inherited
Calcium-dependent phosphotriesterase0.02141Inherited
RuvA domain 2-like0.02141Inherited
Growth factor receptor domain0.05587Inherited
TNF receptor-like0.06859Inherited
EGF/Laminin0.0962Inherited
Ubiquitin-like0.1768Inherited
MHC antigen-recognition domain0.198Inherited
RNA-binding domain, RBD0.2369Inherited
Snake toxin-like0.2592Inherited
WD40 repeat-like0.3622Inherited
4-helical cytokines0.5126Inherited
ABC transporter transmembrane region0.6167Inherited
Intermediate filament protein, coiled coil region0.724Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
beta-glycanases0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Notch domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
Ras-binding domain, RBD0.001443Inherited
STAT DNA-binding domain0.001443Inherited
STAT0.001443Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001443Inherited
Transcription factor STAT-4 N-domain0.001443Inherited
DEATH domain, DD0.001591Inherited
TB module/8-cys domain0.004834Inherited
VWC domain0.006001Inherited
Laminin-type module0.01752Inherited
Arylsulfatase0.04871Inherited
C1 set domains (antibody constant domain-like)0.07375Inherited
Canonical RBD0.1412Inherited
Tetratricopeptide repeat (TPR)0.1547Inherited
MHC antigen-recognition domain0.1754Inherited
Eukaryotic proteases0.1954Inherited
RecA protein-like (ATPase-domain)0.234Inherited
Filamin repeat (rod domain)0.3113Inherited
ABC transporter transmembrane region0.425Inherited
ABC transporter ATPase domain-like0.4798Inherited
Intermediate filament protein, coiled coil region0.7111Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Tricorn protease domain 20Direct
Notch domain0Direct
Saposin0Direct
Transcription factor STAT-4 N-domain0.001337Inherited
STAT0.001337Inherited
RCC1/BLIP-II0.001853Inherited
DEATH domain0.002514Inherited
TB module/8-cys domain0.004605Inherited
RuvA domain 2-like0.01478Inherited
Calcium-dependent phosphotriesterase0.01478Inherited
Growth factor receptor domain0.04202Inherited
TNF receptor-like0.05247Inherited
EGF/Laminin0.07573Inherited
Ubiquitin-like0.1467Inherited
MHC antigen-recognition domain0.1663Inherited
RNA-binding domain, RBD0.2022Inherited
Snake toxin-like0.2229Inherited
Immunoglobulin0.2596Inherited
WD40 repeat-like0.321Inherited
Trypsin-like serine proteases0.3685Inherited
Cystine-knot cytokines0.4138Inherited
4-helical cytokines0.4693Inherited
ABC transporter transmembrane region0.5766Inherited
Intermediate filament protein, coiled coil region0.6868Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8579Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.001337Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001337Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001337Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.004605Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004605Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.007305Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01287Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.04218Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.09143Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1663Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.2999Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5766Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001337Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001337Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004605Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004605Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.004644Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.005701Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.01478Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04218Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1663Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.2999Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)