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Phenotypic Abnormality (PA): Abnormal homeostasis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(76|83) (79|38|16)
0:   Abnormal homeostasis [HP:0012337] <8>(42|43) (42|21|8)
- 1:   Abnormal glucose homeostasis [HP:0011014] <7>(10|11) (11|7|4)
- 1:   Abnormality of acid-base homeostasis [HP:0004360] <7>(19|15) (19|7|2)
- 1:   Abnormality of temperature regulation [HP:0004370] <6>(9|12) (9|6|2)
- 1:   Abnormal energy expenditure [HP:0012338] <2>(0|0) (0|0|0)
- 1:   Abnormal sweat homeostasis [HP:0040127] <2>(0|0) (0|0|0)
- 1:   Abnormality of fluid regulation [HP:0011032] <2>(8|8) (7|2|1)
- 1:   Food intolerance [HP:0012537] <1>(0|0) (0|0|0)
- 1:   Excessive purine production [HP:0003142](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Plakin repeat0Direct
Apolipoprotein A-I0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Fibrinogen coiled-coil and central regions0Direct
Smc hinge domain0Direct
MHC antigen-recognition domain0.005973Inherited
Transcription factor STAT-4 N-domain0.007362Inherited
STAT0.007362Inherited
ClpP/crotonase0.01351Inherited
Thiolase-like0.01823Inherited
Ras GEF0.01823Inherited
Glutathione synthetase ATP-binding domain-like0.02689Inherited
PreATP-grasp domain0.02706Inherited
HD-domain/PDEase-like0.02706Inherited
Terpenoid synthases0.04266Inherited
Insulin-like0.04266Inherited
GAF domain-like0.04266Inherited
Rudiment single hybrid motif0.04266Inherited
Ribonuclease H-like0.05944Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.08095Inherited
4-helical cytokines0.1189Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1557Inherited
Translation proteins0.1623Inherited
SCOP hierarchy in SUPERFAMILY0.1629Inherited
Class II aaRS and biotin synthetases0.1692Inherited
Nucleotidylyl transferase0.1692Inherited
SH2 domain0.1855Inherited
Adenine nucleotide alpha hydrolases-like0.2125Inherited
Single hybrid motif0.2626Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2852Inherited
Acyl-CoA dehydrogenase NM domain-like0.2852Inherited
4Fe-4S ferredoxins0.29Inherited
DEATH domain0.3491Inherited
E set domains0.4914Inherited
Voltage-gated potassium channels0.4976Inherited
Complement control module/SCR domain0.498Inherited
Fibrinogen C-terminal domain-like0.5036Inherited
FAD/NAD(P)-binding domain0.6032Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.7077Inherited
Nicotinic receptor ligand binding domain-like0.8078Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.8078Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Apolipoprotein A-I0Direct
Proteasome subunits0Direct
HCDH C-domain-like0Direct
Amylase, catalytic domain0Direct
IF2B-like0Direct
Long-chain cytokines0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Fibrinogen coiled-coil and central regions0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Plakin repeat0Direct
MHC antigen-recognition domain0.004482Inherited
BC ATP-binding domain-like0.005369Inherited
BC N-terminal domain-like0.005369Inherited
STAT DNA-binding domain0.005369Inherited
Transcription factor STAT-4 N-domain0.005369Inherited
STAT0.005369Inherited
Ras GEF0.01384Inherited
Insulin-like0.03402Inherited
BC C-terminal domain-like0.03402Inherited
GAF domain0.03402Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.03402Inherited
Crotonase-like0.04277Inherited
PDEase0.04389Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.04819Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.04933Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.04933Inherited
Cytoplasmic domain of inward rectifier potassium channel0.07818Inherited
Caspase recruitment domain, CARD0.08897Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.1212Inherited
SH2 domain0.1713Inherited
Ras-binding domain, RBD0.1892Inherited
Biotinyl/lipoyl-carrier proteins and domains0.2392Inherited
Branched-chain alpha-keto acid dehydrogenase Pyr module0.2624Inherited
Pyrin domain, PYD0.2624Inherited
Branched-chain alpha-keto acid dehydrogenase PP module0.2624Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.414Inherited
Complement control module/SCR domain0.4755Inherited
Fibrinogen C-terminal domain-like0.4819Inherited
Phosphotyrosine-binding domain (PTB)0.5Inherited
Voltage-gated potassium channels0.7983Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.8015Inherited
Nicotinic receptor ligand binding domain-like0.8015Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Apolipoprotein A-I0Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Plakin repeat0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
MHC antigen-recognition domain0.003747Inherited
Transcription factor STAT-4 N-domain0.004701Inherited
STAT0.004701Inherited
ClpP/crotonase0.009005Inherited
Thiolase-like0.01239Inherited
Ras GEF0.01239Inherited
Glutathione synthetase ATP-binding domain-like0.01885Inherited
PreATP-grasp domain0.019Inherited
HD-domain/PDEase-like0.019Inherited
Terpenoid synthases0.0312Inherited
GAF domain-like0.0312Inherited
Insulin-like0.0312Inherited
Rudiment single hybrid motif0.0312Inherited
Ribonuclease H-like0.04499Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.06278Inherited
4-helical cytokines0.09518Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1282Inherited
Translation proteins0.1339Inherited
Class II aaRS and biotin synthetases0.1399Inherited
Nucleotidylyl transferase0.1399Inherited
SH2 domain0.1547Inherited
Adenine nucleotide alpha hydrolases-like0.1796Inherited
Single hybrid motif0.2261Inherited
Acyl-CoA dehydrogenase NM domain-like0.2473Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2473Inherited
4Fe-4S ferredoxins0.252Inherited
DEATH domain0.3085Inherited
E set domains0.4479Inherited
Voltage-gated potassium channels0.4542Inherited
Complement control module/SCR domain0.4546Inherited
Fibrinogen C-terminal domain-like0.4601Inherited
FAD/NAD(P)-binding domain0.562Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.6699Inherited
Homeodomain-like0.7245Inherited
Nicotinic receptor ligand binding domain-like0.7741Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7741Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.001701Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.003747Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.004701Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.004701Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.004701Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01239Inherited
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0.01239Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.0312Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.0312Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0312Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0312Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.03925Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.07069Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.2473Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3098Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.7741Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.004701Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.004701Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.0312Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0312Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1796Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3803Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4687Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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