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Phenotypic Abnormality (PA): Abnormal synaptic transmission

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
0:   Abnormal synaptic transmission [HP:0012535] <1>(6|6) (6|2|0)
- 1:   Abnormal peripheral nervous system synaptic transmission [HP:0030191] <2>(6|6) (6|2|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Calcium-dependent phosphotriesterase0.00006655Direct
MIR domain0.0006837Direct
Intermediate filament protein, coiled coil region0.0007546Direct
RNA-binding domain, RBD0.0008879Direct
Nicotinic receptor ligand binding domain-like0.007427Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.007427Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
Canonical RBD0.0003246Direct
MIR domain0.0004132Direct
Intermediate filament protein, coiled coil region0.0004654Direct
Nicotinic receptor ligand binding domain-like0.005264Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.005264Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Calcium-dependent phosphotriesterase0.00003136Direct
MIR domain0.0003607Direct
Intermediate filament protein, coiled coil region0.0004019Direct
RNA-binding domain, RBD0.0004787Direct
Nicotinic receptor ligand binding domain-like0.004745Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.004745Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.002088Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.004745Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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