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Phenotypic Abnormality (PA): Abnormality of nervous system physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
0:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
- 1:   Behavioral abnormality [HP:0000708] <38>(15|25) (20|16|6)
- 1:   Abnormality of movement [HP:0100022] <19>(26|25) (28|13|2)
- 1:   Encephalopathy [HP:0001298] <11>(6|6) (6|2|0)
- 1:   Abnormality of central motor function [HP:0011442] <10>(18|24) (27|15|5)
- 1:   Abnormality of higher mental function [HP:0011446] <9>(38|46) (42|25|8)
- 1:   Seizures [HP:0001250] <8>(12|14) (12|5|1)
- 1:   Headache [HP:0002315] <7>(3|4) (3|2|0)
- 1:   Dysphagia [HP:0002015] <5>(1|1) (1|0|0)
- 1:   Neurodevelopmental abnormality [HP:0012759] <5>(34|50) (39|26|11)
- 1:   Abnormal cranial nerve physiology [HP:0031910] <4>(1|0) (1|1|0)
- 1:   Abnormality of central sensory function [HP:0011730] <4>(0|0) (0|0|0)
- 1:   Abnormal hypothalamus physiology [HP:0012285] <3>(0|0) (0|0|0)
- 1:   Abnormal nervous system electrophysiology [HP:0001311] <2>(8|10) (9|2|0)
- 1:   Abnormality of intracranial pressure [HP:0012640] <2>(2|2) (2|1|0)
- 1:   Abnormality of taste sensation [HP:0000223] <2>(0|0) (0|0|0)
- 1:   Abnormality of the sense of smell [HP:0004408] <2>(1|2) (3|2|0)
- 1:   Brain imaging abnormality [HP:0410263] <2>(0|0) (0|0|0)
- 1:   Pseudobulbar signs [HP:0002200] <2>(1|1) (1|0|0)
- 1:   Abnormal synaptic transmission [HP:0012535] <1>(6|6) (6|2|0)
- 1:   Abnormality of pineal physiology [HP:0012688] <1>(0|0) (0|0|0)
- 1:   Bulbar palsy [HP:0001283](0|0) (0|0|0)
- 1:   Bulbar signs [HP:0002483](0|0) (0|0|0)
- 1:   Cataplexy [HP:0002524](0|0) (0|0|0)
- 1:   Easy fatigability [HP:0003388](0|2) (2|1|0)
- 1:   Hypocalcemic tetany [HP:0003472](0|0) (0|0|0)
- 1:   Lhermitte's sign [HP:0032504](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
HIT-like0Direct
Notch domain0Direct
Ribonuclease PH domain 2-like0Direct
BRK domain-like0Direct
Methylglyoxal synthase-like0Direct
SNARE fusion complex0Direct
beta-sandwich domain of Sec23/240Direct
L27 domain0Direct
Putative DNA-binding domain0Direct
Zn-finger domain of Sec23/240Direct
GAF domain-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
FKBP-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
PP2C-like0Direct
LuxS/MPP-like metallohydrolase0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Nucleoside diphosphate kinase, NDK0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
DBL homology domain (DH-domain)0Direct
Calcium-dependent phosphotriesterase0Direct
Lamin A/C globular tail domain0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Restriction endonuclease-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Nicotinic receptor ligand binding domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
GroEL apical domain-like0Direct
Pseudouridine synthase0Direct
4Fe-4S ferredoxins0Direct
TB module/8-cys domain0Direct
L-aspartase-like0Direct
CCCH zinc finger0Direct
Adenine nucleotide alpha hydrolases-like0Direct
Translation proteins0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Actin depolymerizing proteins0Direct
CRAL/TRIO domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
JAB1/MPN domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
S15/NS1 RNA-binding domain0Direct
Thiolase-like0Direct
Hook domain0Direct
RuvA domain 2-like0Direct
CoA-dependent acyltransferases0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
GroEL equatorial domain-like0Direct
Hect, E3 ligase catalytic domain0Direct
Helical domain of Sec23/240Direct
Rhodanese/Cell cycle control phosphatase0Direct
GroEL-intermediate domain like0Direct
ThrRS/AlaRS common domain0Direct
Multidrug resistance efflux transporter EmrE0Direct
GroES-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
ADC-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Smc hinge domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Arginase/deacetylase0Direct
Subtilisin-like0Direct
Proton glutamate symport protein0Direct
EF-G C-terminal domain-like0Direct
Voltage-gated potassium channels0.005064Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.07628Inherited
Acyl-CoA dehydrogenase NM domain-like0.07628Inherited
Periplasmic binding protein-like II0.09685Inherited
Single hybrid motif0.1234Inherited
PreATP-grasp domain0.1234Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.156Inherited
Chaperone J-domain0.1641Inherited
SET domain0.1848Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.197Inherited
MIR domain0.197Inherited
GST C-terminal domain-like0.197Inherited
HSP20-like chaperones0.2486Inherited
ARID-like0.2486Inherited
Periplasmic binding protein-like I0.2556Inherited
FabD/lysophospholipase-like0.3132Inherited
Sema domain0.3435Inherited
Rudiment single hybrid motif0.3968Inherited
Cap-Gly domain0.3968Inherited
(Trans)glycosidases0.3986Inherited
Ribosomal protein S5 domain 2-like0.4807Inherited
NagB/RpiA/CoA transferase-like0.4849Inherited
Bromodomain0.5028Inherited
Mitochondrial carrier0.5514Inherited
cAMP-binding domain-like0.5514Inherited
PH domain-like0.5789Inherited
RNA-binding domain, RBD0.5922Inherited
ClpP/crotonase0.6247Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.6334Inherited
Tropomyosin0.6773Inherited
Glycosyl hydrolase domain0.6955Inherited
Cysteine proteinases0.6972Inherited
POZ domain0.7663Inherited
vWA-like0.7735Inherited
Integrin domains0.8189Inherited
KRAB domain (Kruppel-associated box)0.8328Inherited
Intermediate filament protein, coiled coil region0.8441Inherited
DEATH domain0.8962Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Phosphate binding protein-like0Direct
Ribonuclease PH domain 1-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
a tRNA synthase domain0Direct
Nicotinic receptor ligand binding domain-like0Direct
Ferredoxin domains from multidomain proteins0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
JAB1/MPN domain0Direct
Helical domain of Sec23/240Direct
Smc hinge domain0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
TB module/8-cys domain0Direct
Pyridoxal-dependent decarboxylase0Direct
Amylase, catalytic domain0Direct
beta-sandwich domain of Sec23/240Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Anticodon-binding domain0Direct
Notch domain0Direct
beta-glycanases0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
BRK domain-like0Direct
Proton glutamate symport protein0Direct
Choline/Carnitine O-acyltransferase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Translational machinery components0Direct
Subtilases0Direct
Trunk domain of Sec23/240Direct
Ypt/Rab-GAP domain of gyp1p0Direct
DEP domain0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
Zn-finger domain of Sec23/240Direct
Glycosyl transferases group 10Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
MPP-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Prefoldin0Direct
SNARE fusion complex0Direct
Clathrin adaptor core protein0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Histone lysine methyltransferases0Direct
GAF domain0Direct
IF2B-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
N-acetyl transferase, NAT0Direct
CCCH zinc finger0Direct
L27 domain0Direct
CAT-like0Direct
Histone deacetylase, HDAC0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
PWWP domain0Direct
FKBP immunophilin/proline isomerase0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
CUT domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0Direct
Caspase recruitment domain, CARD0Direct
Exostosin0Direct
PP2C-like0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
UBA domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Filamin repeat (rod domain)0Direct
Ribonuclease PH domain 2-like0Direct
RhoGDI-like0Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Lamin A/C globular tail domain0Direct
DBL homology domain (DH-domain)0Direct
L-aspartase/fumarase0Direct
p120GAP domain-like0Direct
Hect, E3 ligase catalytic domain0Direct
SWIRM domain0Direct
EF-G/eEF-2 domains III and V0Direct
Myotubularin-like phosphatases0Direct
Protein serine/threonine phosphatase0Direct
Elongation factors0Direct
Voltage-gated potassium channels0.01885Inherited
Extended AAA-ATPase domain0.03348Inherited
FHA domain0.07419Inherited
HMG-box0.08297Inherited
Biotinyl/lipoyl-carrier proteins and domains0.09607Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.09607Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.09607Inherited
Chaperone J-domain0.1307Inherited
Tetramerization domain of potassium channels0.1611Inherited
MIR domain0.1615Inherited
BC ATP-binding domain-like0.2092Inherited
ARID domain0.2092Inherited
BC N-terminal domain-like0.2092Inherited
Clathrin coat assembly domain0.2092Inherited
28-residue LRR0.2432Inherited
Pyrin domain, PYD0.2706Inherited
Sema domain0.2962Inherited
L-arabinose binding protein-like0.2991Inherited
PHD domain0.3489Inherited
Cap-Gly domain0.3515Inherited
ZZ domain0.3515Inherited
BC C-terminal domain-like0.3515Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.4089Inherited
MHC antigen-recognition domain0.4152Inherited
VWC domain0.4361Inherited
Bromodomain0.4535Inherited
Mitochondrial carrier0.5023Inherited
cAMP-binding domain0.5585Inherited
Tropomyosin0.6352Inherited
Canonical RBD0.653Inherited
Myosin rod fragments0.7167Inherited
Integrin A (or I) domain0.7711Inherited
DNA gyrase/MutL, second domain0.7718Inherited
DNA gyrase/MutL, N-terminal domain0.7718Inherited
Integrin domains0.7865Inherited
KRAB domain (Kruppel-associated box)0.8016Inherited
Intermediate filament protein, coiled coil region0.8046Inherited
ABC transporter ATPase domain-like0.8061Inherited
Nucleotide and nucleoside kinases0.9243Inherited
Complement control module/SCR domain0.9935Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nucleoside diphosphate kinase, NDK0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
CRAL/TRIO domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Nicotinic receptor ligand binding domain-like0Direct
Subtilisin-like0Direct
GroES-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
beta-sandwich domain of Sec23/240Direct
BRK domain-like0Direct
SAND domain-like0Direct
SNARE fusion complex0Direct
JAB1/MPN domain0Direct
Hook domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Calcium-dependent phosphotriesterase0Direct
S15/NS1 RNA-binding domain0Direct
Helical domain of Sec23/240Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
ADC-like0Direct
Smc hinge domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
L-aspartase-like0Direct
Multidrug resistance efflux transporter EmrE0Direct
Restriction endonuclease-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Lamin A/C globular tail domain0Direct
Actin depolymerizing proteins0Direct
EF-G C-terminal domain-like0Direct
DBL homology domain (DH-domain)0Direct
Arginase/deacetylase0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Translation proteins0Direct
GroEL apical domain-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
TB module/8-cys domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
LuxS/MPP-like metallohydrolase0Direct
Notch domain0Direct
HIT-like0Direct
Adenine nucleotide alpha hydrolases-like0Direct
PP2C-like0Direct
Thiolase-like0Direct
Putative DNA-binding domain0Direct
GAF domain-like0Direct
CoA-dependent acyltransferases0Direct
Zn-finger domain of Sec23/240Direct
Methylglyoxal synthase-like0Direct
Ribonuclease PH domain 2-like0Direct
GroEL-intermediate domain like0Direct
CCCH zinc finger0Direct
Tricorn protease domain 20Direct
L27 domain0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
4Fe-4S ferredoxins0Direct
GroEL equatorial domain-like0Direct
RuvA domain 2-like0Direct
ThrRS/AlaRS common domain0Direct
Hect, E3 ligase catalytic domain0Direct
Pseudouridine synthase0Direct
FKBP-like0Direct
Proton glutamate symport protein0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Voltage-gated potassium channels0.00313Inherited
Acyl-CoA dehydrogenase NM domain-like0.05893Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.05893Inherited
Glutathione synthetase ATP-binding domain-like0.05893Inherited
Periplasmic binding protein-like II0.07634Inherited
HMG-box0.08718Inherited
Single hybrid motif0.09924Inherited
PreATP-grasp domain0.09924Inherited
BRCT domain0.09924Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.1285Inherited
Chaperone J-domain0.1355Inherited
SET domain0.1541Inherited
MIR domain0.1653Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1653Inherited
GST C-terminal domain-like0.1653Inherited
RNI-like0.1847Inherited
HSP20-like chaperones0.2127Inherited
ARID-like0.2127Inherited
Periplasmic binding protein-like I0.2194Inherited
FabD/lysophospholipase-like0.2742Inherited
ARM repeat0.2872Inherited
Sema domain0.3031Inherited
Cap-Gly domain0.3548Inherited
Rudiment single hybrid motif0.3548Inherited
(Trans)glycosidases0.3565Inherited
MHC antigen-recognition domain0.4227Inherited
Ribosomal protein S5 domain 2-like0.4373Inherited
NagB/RpiA/CoA transferase-like0.4412Inherited
Bromodomain0.4594Inherited
cAMP-binding domain-like0.509Inherited
Mitochondrial carrier0.509Inherited
PH domain-like0.5368Inherited
HAD-like0.5497Inherited
RNA-binding domain, RBD0.5506Inherited
ClpP/crotonase0.5849Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5937Inherited
Tropomyosin0.6388Inherited
Glycosyl hydrolase domain0.6575Inherited
Cysteine proteinases0.6592Inherited
(Phosphotyrosine protein) phosphatases II0.679Inherited
Myosin rod fragments0.7191Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.7212Inherited
Calcium ATPase, transmembrane domain M0.7241Inherited
POZ domain0.7306Inherited
vWA-like0.7381Inherited
Calcium ATPase, transduction domain A0.776Inherited
Integrin domains0.7857Inherited
KRAB domain (Kruppel-associated box)0.8Inherited
Intermediate filament protein, coiled coil region0.8116Inherited
Ribonuclease H-like0.8496Inherited
DEATH domain0.867Inherited
"Winged helix" DNA-binding domain0.9356Inherited
Immunoglobulin0.9995Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    81296,48239
  • 81296 - E set domains
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.05893Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1283Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2044Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2742Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3031Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.3031Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.3548Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4113Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.4227Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.4898Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.526Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.5849Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.6575Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.7212Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.7691Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.8114Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.8114Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.986Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.05893Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3082Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.3548Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.4898Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.7212Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9661Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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