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Phenotypic Abnormality (PA): Abnormal inflammatory response

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the immune system [HP:0002715] <3>(37|52) (39|28|15)
+ 1:   Abnormality of immune system physiology [HP:0010978] <14>(29|40) (31|23|11)
0:   Abnormal inflammatory response [HP:0012647] <2>(17|22) (18|11|3)
- 1:   Increased inflammatory response [HP:0012649] <27>(15|20) (16|9|3)
- 1:   Decreased inflammatory response [HP:0012648](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
DNA/RNA polymerases0.0002911Direct
DEATH domain0.007558Inherited
Transcription factor STAT-4 N-domain0.01401Inherited
STAT0.01401Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.03029Inherited
Trypsin-like serine proteases0.0992Inherited
MHC antigen-recognition domain0.1137Inherited
SH2 domain0.1675Inherited
TNF-like0.2229Inherited
Cysteine-rich domain0.2364Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3044Inherited
Immunoglobulin0.3541Inherited
RNI-like0.4431Inherited
4-helical cytokines0.4661Inherited
TNF receptor-like0.5818Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.9236Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Anaphylotoxins (complement system)0Direct
Netrin-like domain (NTR/C345C module)0Direct
Pyrin domain, PYD0.002956Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01061Inherited
STAT DNA-binding domain0.01078Inherited
STAT0.01078Inherited
Transcription factor STAT-4 N-domain0.01078Inherited
Caspase recruitment domain, CARD0.03146Inherited
C1 set domains (antibody constant domain-like)0.04906Inherited
Noncollagenous (NC1) domain of collagen IV0.06201Inherited
PHD domain0.08188Inherited
MHC antigen-recognition domain0.1051Inherited
Eukaryotic proteases0.1178Inherited
SH2 domain0.1653Inherited
28-residue LRR0.1733Inherited
DEATH domain, DD0.2149Inherited
TNF-like0.2149Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2841Inherited
PLC-like (P variant)0.5402Inherited
Laminin-type module0.7371Inherited
I set domains0.7512Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
DNA/RNA polymerases0.0001476Direct
DEATH domain0.004836Inherited
Transcription factor STAT-4 N-domain0.009374Inherited
STAT0.009374Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.02147Inherited
Trypsin-like serine proteases0.07839Inherited
MHC antigen-recognition domain0.09064Inherited
SH2 domain0.1384Inherited
TNF-like0.1888Inherited
Cysteine-rich domain0.2016Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2658Inherited
Immunoglobulin0.3132Inherited
Snake toxin-like0.3412Inherited
RNI-like0.4001Inherited
4-helical cytokines0.423Inherited
TNF receptor-like0.5396Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8963Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002512Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.009374Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.009374Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.009374Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.009404Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.09064Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1305Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.619Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.009374Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.009374Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3412Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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