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Phenotypic Abnormality (PA): Abnormality of digestive system physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the digestive system [HP:0025031] <6>(63|72) (76|45|24)
0:   Abnormality of digestive system physiology [HP:0025032] <5>(26|31) (35|16|2)
- 1:   Abdominal symptom [HP:0011458] <12>(15|19) (19|11|2)
- 1:   Functional abnormality of the gastrointestinal tract [HP:0012719] <11>(9|11) (14|2|0)
- 1:   Abnormal large intestine physiology [HP:0012700] <4>(0|0) (0|0|0)
- 1:   Abnormality of hepatobiliary system physiology [HP:0025155] <3>(2|2) (2|2|0)
- 1:   Dependency on intravenous nutrition [HP:0025156](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
ADC-like0Direct
BPTI-like0Direct
Plakin repeat0Direct
Ribonuclease PH domain 2-like0Direct
Tricorn protease domain 20Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
SAND domain-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0006736Direct
Adenine nucleotide alpha hydrolases-like0.01289Inherited
ValRS/IleRS/LeuRS editing domain0.02559Inherited
4Fe-4S ferredoxins0.09038Inherited
MHC antigen-recognition domain0.09482Inherited
RNI-like0.1055Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1602Inherited
Acyl-CoA dehydrogenase NM domain-like0.1602Inherited
DEATH domain0.2454Inherited
SpoIIaa-like0.3197Inherited
Immunoglobulin0.3481Inherited
Complement control module/SCR domain0.3809Inherited
Ran binding protein zinc finger-like0.5505Inherited
Integrin domains0.5505Inherited
L domain-like0.7118Inherited
Intermediate filament protein, coiled coil region0.7703Inherited
Actin-like ATPase domain0.7828Inherited
Homeodomain-like0.8028Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Plakin repeat0Direct
P4 origin-binding domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Ribonuclease PH domain 1-like0Direct
Ribonuclease PH domain 2-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Small Kunitz-type inhibitors & BPTI-like toxins0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0009463Direct
Histone lysine methyltransferases0.009387Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01788Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01788Inherited
ValRS/IleRS/LeuRS editing domain0.01912Inherited
DNA gyrase/MutL, second domain0.03824Inherited
DNA gyrase/MutL, N-terminal domain0.03824Inherited
C1 set domains (antibody constant domain-like)0.05522Inherited
MHC antigen-recognition domain0.08062Inherited
Nitrogenase iron protein-like0.1033Inherited
28-residue LRR0.1709Inherited
SNARE fusion complex0.1765Inherited
Anti-sigma factor antagonist SpoIIaa0.1765Inherited
Actin/HSP700.2119Inherited
Complement control module/SCR domain0.3511Inherited
BC ATP-binding domain-like0.412Inherited
Pyrin domain, PYD0.412Inherited
BC N-terminal domain-like0.412Inherited
Integrin domains0.5181Inherited
Ran binding protein zinc finger-like0.5181Inherited
Intermediate filament protein, coiled coil region0.762Inherited
Transforming growth factor (TGF)-beta0.7643Inherited
Ngr ectodomain-like0.8223Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
ADC-like0Direct
Tricorn protease domain 20Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribonuclease PH domain 2-like0Direct
Plakin repeat0Direct
Fibrinogen coiled-coil and central regions0Direct
BPTI-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0003553Direct
Adenine nucleotide alpha hydrolases-like0.008568Inherited
ValRS/IleRS/LeuRS editing domain0.01784Inherited
Transcription factor STAT-4 N-domain0.01784Inherited
STAT0.01784Inherited
Calcium-dependent phosphotriesterase0.07069Inherited
4Fe-4S ferredoxins0.07069Inherited
MHC antigen-recognition domain0.07457Inherited
RNI-like0.0835Inherited
Acyl-CoA dehydrogenase NM domain-like0.1321Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1321Inherited
SNARE fusion complex0.1691Inherited
beta-sandwich domain of Sec23/240.2062Inherited
DEATH domain0.21Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2625Inherited
SpoIIaa-like0.2805Inherited
Immunoglobulin0.3075Inherited
Complement control module/SCR domain0.3392Inherited
Ran binding protein zinc finger-like0.508Inherited
4-helical cytokines0.508Inherited
Snake toxin-like0.508Inherited
Integrin domains0.508Inherited
L domain-like0.6739Inherited
Intermediate filament protein, coiled coil region0.7346Inherited
Actin-like ATPase domain0.7477Inherited
Homeodomain-like0.7691Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.7874Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01784Inherited
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0.01784Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01784Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01784Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03567Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.03567Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.07457Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1321Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.3485Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3903Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.6703Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01784Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01784Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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