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Phenotypic Abnormality (PA): Constitutional symptom

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Constitutional symptom [HP:0025142] <12>(8|16) (11|8|3)
- 1:   Pain [HP:0012531] <35>(5|12) (8|5|0)
- 1:   Impairment of activities of daily living [HP:0031058] <6>(0|0) (0|0|0)
- 1:   Fatigue [HP:0012378] <3>(3|6) (3|4|2)
- 1:   Body odor [HP:0500001] <2>(0|0) (0|0|0)
- 1:   Chills [HP:0025143] <1>(0|0) (0|0|0)
- 1:   Halitosis [HP:0100812] <1>(0|1) (0|0|1)
- 1:   Shivering [HP:0025144] <1>(0|0) (0|0|0)
- 1:   Asthenia [HP:0025406](0|0) (0|0|0)
- 1:   Chest tightness [HP:0031352](0|0) (0|0|0)
- 1:   Gangrene [HP:0100758](2|3) (2|3|2)
- 1:   Hot flashes [HP:0031217](0|0) (0|0|0)
- 1:   Night sweats [HP:0030166](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
MHC antigen-recognition domain0.004499Inherited
DEATH domain0.005233Inherited
Calcium-dependent phosphotriesterase0.01672Inherited
Transcription factor STAT-4 N-domain0.01724Inherited
STAT0.01724Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1704Inherited
Acyl-CoA dehydrogenase NM domain-like0.1704Inherited
RNI-like0.273Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
C1 set domains (antibody constant domain-like)0.0009042Direct
MHC antigen-recognition domain0.003191Inherited
DNA gyrase/MutL, second domain0.003587Inherited
DNA gyrase/MutL, N-terminal domain0.003587Inherited
Transcription factor STAT-4 N-domain0.01278Inherited
STAT DNA-binding domain0.01278Inherited
STAT0.01278Inherited
Adenosine/AMP deaminase0.03574Inherited
Pyrin domain, PYD0.03574Inherited
Eukaryotic proteases0.06398Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.07933Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.07933Inherited
28-residue LRR0.1128Inherited
Tetratricopeptide repeat (TPR)0.5389Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MHC antigen-recognition domain0.002707Inherited
DEATH domain0.003193Inherited
Calcium-dependent phosphotriesterase0.01121Inherited
Transcription factor STAT-4 N-domain0.01157Inherited
STAT0.01157Inherited
Trypsin-like serine proteases0.07115Inherited
Metallo-dependent hydrolases0.1034Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1034Inherited
Acyl-CoA dehydrogenase NM domain-like0.1403Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1403Inherited
RNI-like0.2348Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.002707Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.003168Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003168Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01157Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01157Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01157Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1403Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01157Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01157Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.148Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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