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Phenotypic Abnormality (PA): Abnormal spleen morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ + + 3:   Abnormality of the vasculature [HP:0002597] <13>(35|56) (45|27|18)
+ + + 3:   Abnormality of the digestive system [HP:0025031] <6>(67|77) (77|47|25)
+ + 2:   Abnormality of the lymphatic system [HP:0100763] <7>(9|19) (15|8|5)
+ + 2:   Abnormality of the abdominal organs [HP:0002012] <6>(27|27) (30|14|4)
+ 1:   Abnormality of the spleen [HP:0001743] <2>(7|14) (9|4|3)
0:   Abnormal spleen morphology [HP:0025408] <11>(7|13) (9|4|3)
- 1:   Aplasia/Hypoplasia of the spleen [HP:0010451] <2>(0|1) (0|0|1)
- 1:   Splenic abscess [HP:0025059] <2>(0|0) (0|0|0)
- 1:   Supernumerary spleens [HP:0009799] <2>(0|0) (0|0|0)
- 1:   Splenomegaly [HP:0001744] <1>(4|10) (6|4|2)
- 1:   Ectopia of the spleen [HP:0010452](0|0) (0|0|0)
- 1:   Hepatosplenomegaly [HP:0001433](0|0) (0|0|0)
- 1:   Multilobulated spleen [HP:0020186](0|0) (0|0|0)
- 1:   Splenic cyst [HP:0030423](0|0) (0|0|0)
- 1:   Splenic rupture [HP:0012223](2|2) (2|0|0)
- 1:   Splenogonadal fusion [HP:0025410](0|0) (0|0|0)
- 1:   Splenopancreatic fusion [HP:0032075](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
DEATH domain0.000001514Direct
TNF receptor-like0.00002286Direct
Globin-like0.00003979Direct
(Trans)glycosidases0.000958Direct
Notch domain0.001986Inherited
Fibrinogen C-terminal domain-like0.06725Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Globins0.00002257Direct
Pyrin domain, PYD0.0001776Direct
TNF receptor-like0.0004032Direct
beta-glycanases0.001245Inherited
Notch domain0.001245Inherited
28-residue LRR0.001866Inherited
PX domain0.002086Inherited
DEATH domain, DD0.002299Inherited
Tetratricopeptide repeat (TPR)0.04038Inherited
Fibrinogen C-terminal domain-like0.05486Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
DEATH domain0.0000006066Direct
TNF receptor-like0.000009927Direct
Globin-like0.00001765Direct
(Trans)glycosidases0.0005072Direct
Notch domain0.001114Inherited
PX domain0.001855Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.001855Inherited
Fibrinogen C-terminal domain-like0.05102Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000007389Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001471Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001114Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001114Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02582Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)