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Phenotypic Abnormality (PA): Abnormality of cardiovascular system morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
0:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(29|42) (31|19|20)
- 1:   Abnormal heart morphology [HP:0001627] <16>(20|35) (24|16|20)
- 1:   Abnormal vascular morphology [HP:0025015] <12>(15|18) (16|11|10)
- 1:   Cardiovascular calcification [HP:0011915] <3>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
RmlC-like cupins0Direct
TB module/8-cys domain0Direct
Smc hinge domain0Direct
p53-like transcription factors0.01523Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.06633Inherited
(Trans)glycosidases0.08521Inherited
Hemopexin-like domain0.114Inherited
Protein kinase-like (PK-like)0.1243Inherited
Myosin rod fragments0.1254Inherited
Tropomyosin0.1254Inherited
PGBD-like0.1883Inherited
Actin-like ATPase domain0.2084Inherited
FnI-like domain0.2255Inherited
MIR domain0.2282Inherited
Spectrin repeat0.2559Inherited
Snake toxin-like0.2854Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3073Inherited
SMAD MH1 domain0.3074Inherited
Ribosomal protein S5 domain 2-like0.3377Inherited
MHC antigen-recognition domain0.3589Inherited
RNI-like0.4559Inherited
SMAD/FHA domain0.4569Inherited
4-helical cytokines0.5403Inherited
FAD/NAD(P)-binding domain0.6623Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7209Inherited
Nicotinic receptor ligand binding domain-like0.7209Inherited
DEATH domain0.8812Inherited
TNF receptor-like0.9758Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Multidrug efflux transporter AcrB transmembrane domain0Direct
ZZ domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Notch domain0Direct
Smc hinge domain0Direct
TB module/8-cys domain0Direct
Actin/HSP700.0003691Direct
Histone lysine methyltransferases0.01301Inherited
Amylase, catalytic domain0.01656Inherited
DNA gyrase/MutL, second domain0.01656Inherited
DNA gyrase/MutL, N-terminal domain0.01656Inherited
Transforming growth factor (TGF)-beta0.03728Inherited
Double-stranded RNA-binding domain (dsRBD)0.03905Inherited
Growth factor receptor domain0.04676Inherited
Extracellular domain of cell surface receptors0.04995Inherited
Protein kinases, catalytic subunit0.062Inherited
T-box0.06884Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.06916Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.06916Inherited
Hemopexin-like domain0.09168Inherited
Myosin rod fragments0.09661Inherited
Tropomyosin0.09661Inherited
Erythroid transcription factor GATA-10.09661Inherited
RecA protein-like (ATPase-domain)0.09661Inherited
VWC domain0.09824Inherited
LIM domain0.1248Inherited
Matrix metalloproteases, catalytic domain0.1577Inherited
MMP N-terminal domain0.1577Inherited
EGF-type module0.1802Inherited
DEATH domain, DD0.1831Inherited
MIR domain0.1883Inherited
Spectrin repeat0.2088Inherited
Tetratricopeptide repeat (TPR)0.2246Inherited
PHD domain0.2246Inherited
beta-glycanases0.2614Inherited
SMAD MH1 domain0.2614Inherited
SMAD domain0.2614Inherited
MHC antigen-recognition domain0.3076Inherited
ABC transporter ATPase domain-like0.5001Inherited
C1 set domains (antibody constant domain-like)0.643Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.689Inherited
Nicotinic receptor ligand binding domain-like0.689Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Notch domain0Direct
TB module/8-cys domain0Direct
RmlC-like cupins0Direct
p53-like transcription factors0.01014Inherited
Restriction endonuclease-like0.03837Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.05023Inherited
(Trans)glycosidases0.06602Inherited
Hemopexin-like domain0.09026Inherited
Protein kinase-like (PK-like)0.09956Inherited
Myosin rod fragments0.1005Inherited
Tropomyosin0.1005Inherited
PGBD-like0.1564Inherited
Actin-like ATPase domain0.1751Inherited
FnI-like domain0.1907Inherited
MIR domain0.1931Inherited
Spectrin repeat0.2186Inherited
Snake toxin-like0.2466Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2672Inherited
SMAD MH1 domain0.2673Inherited
Ribosomal protein S5 domain 2-like0.2962Inherited
MHC antigen-recognition domain0.3167Inherited
RNI-like0.412Inherited
SMAD/FHA domain0.413Inherited
TPR-like0.4619Inherited
4-helical cytokines0.4964Inherited
FAD/NAD(P)-binding domain0.6216Inherited
Nicotinic receptor ligand binding domain-like0.6825Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6825Inherited
DEATH domain0.851Inherited
TNF receptor-like0.9528Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0003018Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.01631Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.04775Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.05566Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1123Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1123Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.1395Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.1564Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3167Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.6511Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.6825Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.951Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.002554Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01067Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05136Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1464Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4031Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.412Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5908Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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