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Phenotypic Abnormality (PA): Abnormality of cardiovascular system morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the cardiovascular system [HP:0001626] <5>(59|81) (72|39|29)
0:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(29|40) (32|17|20)
- 1:   Abnormal heart morphology [HP:0001627] <16>(19|32) (23|14|20)
- 1:   Abnormal vascular morphology [HP:0025015] <12>(15|18) (17|11|10)
- 1:   Cardiovascular calcification [HP:0011915] <3>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Notch domain0Direct
TB module/8-cys domain0Direct
RmlC-like cupins0Direct
Apolipoprotein A-I0Direct
p53-like transcription factors0.01535Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.06482Inherited
(Trans)glycosidases0.08593Inherited
Protein kinase-like (PK-like)0.09011Inherited
Tropomyosin0.1698Inherited
Myosin rod fragments0.1698Inherited
FnI-like domain0.2259Inherited
MIR domain0.2282Inherited
Spectrin repeat0.2561Inherited
Actin-like ATPase domain0.2561Inherited
Ribosomal protein S5 domain 2-like0.2768Inherited
Snake toxin-like0.2846Inherited
SMAD MH1 domain0.3064Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3077Inherited
MHC antigen-recognition domain0.3584Inherited
RNI-like0.4561Inherited
SMAD/FHA domain0.4574Inherited
4-helical cytokines0.54Inherited
FAD/NAD(P)-binding domain0.6548Inherited
Immunoglobulin0.6755Inherited
Nicotinic receptor ligand binding domain-like0.7147Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7147Inherited
DEATH domain0.8822Inherited
TNF receptor-like0.9762Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Apolipoprotein A-I0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Notch domain0Direct
TB module/8-cys domain0Direct
ZZ domain0Direct
Actin/HSP700.0009596Direct
Histone lysine methyltransferases0.01258Inherited
Amylase, catalytic domain0.01618Inherited
DNA gyrase/MutL, second domain0.01618Inherited
DNA gyrase/MutL, N-terminal domain0.01618Inherited
Protein kinases, catalytic subunit0.03529Inherited
Transforming growth factor (TGF)-beta0.036Inherited
Double-stranded RNA-binding domain (dsRBD)0.03844Inherited
Extracellular domain of cell surface receptors0.04895Inherited
T-box0.04933Inherited
Growth factor receptor domain0.06239Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.06997Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.06997Inherited
VWC domain0.09625Inherited
Erythroid transcription factor GATA-10.09707Inherited
RecA protein-like (ATPase-domain)0.09707Inherited
LIM domain0.1221Inherited
Tropomyosin0.1361Inherited
Myosin rod fragments0.1378Inherited
EGF-type module0.1833Inherited
DEATH domain, DD0.1847Inherited
MIR domain0.1892Inherited
Spectrin repeat0.2107Inherited
Tetratricopeptide repeat (TPR)0.2269Inherited
PHD domain0.2269Inherited
beta-glycanases0.2624Inherited
SMAD domain0.2624Inherited
SMAD MH1 domain0.2624Inherited
MHC antigen-recognition domain0.3085Inherited
ABC transporter ATPase domain-like0.5028Inherited
C1 set domains (antibody constant domain-like)0.6452Inherited
Nicotinic receptor ligand binding domain-like0.6824Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6824Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
RmlC-like cupins0Direct
Apolipoprotein A-I0Direct
TB module/8-cys domain0Direct
Notch domain0Direct
p53-like transcription factors0.01032Inherited
Acyl-CoA N-acyltransferases (Nat)0.01609Inherited
Restriction endonuclease-like0.0379Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04936Inherited
(Trans)glycosidases0.0669Inherited
Protein kinase-like (PK-like)0.07049Inherited
Myosin rod fragments0.1404Inherited
Tropomyosin0.1404Inherited
FnI-like domain0.1915Inherited
MIR domain0.1938Inherited
Spectrin repeat0.2198Inherited
Actin-like ATPase domain0.2198Inherited
Ribosomal protein S5 domain 2-like0.2396Inherited
Snake toxin-like0.2468Inherited
SMAD MH1 domain0.2677Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.269Inherited
MHC antigen-recognition domain0.3173Inherited
RNI-like0.4131Inherited
SMAD/FHA domain0.4145Inherited
4-helical cytokines0.4972Inherited
FAD/NAD(P)-binding domain0.6158Inherited
Immunoglobulin0.6368Inherited
EF-hand0.6738Inherited
Nicotinic receptor ligand binding domain-like0.677Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.677Inherited
DEATH domain0.8521Inherited
TNF receptor-like0.9531Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.000755Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.01609Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.04833Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.04836Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1134Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1473Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3173Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.6519Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.677Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.9515Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.002484Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01041Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05065Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1473Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4045Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.4131Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5917Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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