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Phenotypic Abnormality (PA): Abnormal immune system morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
0:   Abnormal immune system morphology [HP:0032251] <3>(11|11) (11|6|2)
- 1:   Abscess [HP:0025615] <9>(1|1) (1|0|0)
- 1:   Abnormal cellular immune system morphology [HP:0010987] <1>(10|10) (10|6|2)
- 1:   Granuloma [HP:0032252] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SH2 domain0.000202Direct
Transcription factor STAT-4 N-domain0.002214Inherited
STAT0.002214Inherited
TNF receptor-like0.009052Inherited
DEATH domain0.01942Inherited
SH3-domain0.02774Inherited
Immunoglobulin0.02915Inherited
RNI-like0.07283Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1348Inherited
p53-like transcription factors0.1644Inherited
FYVE/PHD zinc finger0.3502Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
SH2 domain0.0001225Direct
Pyrin domain, PYD0.0003411Direct
Nitrogenase iron protein-like0.001449Inherited
Transcription factor STAT-4 N-domain0.001449Inherited
STAT DNA-binding domain0.001449Inherited
STAT0.001449Inherited
Tandem AAA-ATPase domain0.002595Inherited
SH3-domain0.02033Inherited
V set domains (antibody variable domain-like)0.0212Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.04478Inherited
28-residue LRR0.1129Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SH2 domain0.00009683Direct
Transcription factor STAT-4 N-domain0.001251Inherited
STAT0.001251Inherited
TNF receptor-like0.005785Inherited
DEATH domain0.01316Inherited
SH3-domain0.01936Inherited
Immunoglobulin0.02041Inherited
RNI-like0.05566Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1089Inherited
p53-like transcription factors0.1348Inherited
FYVE/PHD zinc finger0.3083Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001251Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001251Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.001251Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.01271Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02696Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04255Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001251Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001251Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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