SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of limb bone

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the skeletal system [HP:0000924] <7>(88|98) (93|55|34)
+ 1:   Abnormality of limbs [HP:0040064] <8>(58|66) (63|33|25)
0:   Abnormality of limb bone [HP:0040068] <1>(29|32) (33|18|20)
- 1:   Abnormality of limb bone morphology [HP:0002813] <13>(29|32) (32|18|20)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
CalX-like0Direct
RuvA domain 2-like0Direct
WD40 repeat-like0.005014Inherited
SET domain0.01587Inherited
FnI-like domain0.02435Inherited
Hect, E3 ligase catalytic domain0.03857Inherited
Arginase/deacetylase0.04332Inherited
Insulin-like0.04332Inherited
Histone-fold0.09Inherited
ARID-like0.09Inherited
Hemopexin-like domain0.1399Inherited
Restriction endonuclease-like0.147Inherited
Multidrug efflux transporter AcrB transmembrane domain0.147Inherited
BRK domain-like0.147Inherited
vWA-like0.1655Inherited
HLH, helix-loop-helix DNA-binding domain0.2012Inherited
Metalloproteases ("zincins"), catalytic domain0.2054Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2077Inherited
PGBD-like0.2077Inherited
Cystine-knot cytokines0.2683Inherited
Concanavalin A-like lectins/glucanases0.299Inherited
GroEL equatorial domain-like0.3043Inherited
p53-like transcription factors0.4783Inherited
HMG-box0.4799Inherited
Immunoglobulin0.7796Inherited
Voltage-gated potassium channels0.9367Inherited
Class II aaRS and biotin synthetases0.9912Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
CalX-beta domain0Direct
Proteasome subunits0Direct
Notch domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Histone deacetylase, HDAC0Direct
Exostosin0Direct
TB module/8-cys domain0Direct
Actin/HSP700.0001822Direct
Erythroid transcription factor GATA-10.001559Inherited
Transforming growth factor (TGF)-beta0.006726Inherited
VWC domain0.01625Inherited
Hect, E3 ligase catalytic domain0.02554Inherited
ZZ domain0.02999Inherited
Insulin-like0.02999Inherited
PHD domain0.03542Inherited
Integrin A (or I) domain0.05523Inherited
ARID domain0.06767Inherited
Growth factor receptor domain0.07312Inherited
Fibronectin type II module0.08015Inherited
Hemopexin-like domain0.1079Inherited
BRK domain-like0.1163Inherited
TSP-1 type 1 repeat0.1297Inherited
HLH, helix-loop-helix DNA-binding domain0.1519Inherited
Matrix metalloproteases, catalytic domain0.1681Inherited
MMP N-terminal domain0.1681Inherited
Tetratricopeptide repeat (TPR)0.2147Inherited
Homeodomain0.2465Inherited
RecA protein-like (ATPase-domain)0.2883Inherited
Classic zinc finger, C2H20.2887Inherited
HMG-box0.4197Inherited
I set domains0.4922Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.9598Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
CalX-like0Direct
Notch domain0Direct
RuvA domain 2-like0Direct
TB module/8-cys domain0Direct
Protein kinase-like (PK-like)0.0007308Direct
WD40 repeat-like0.003052Inherited
SET domain0.01058Inherited
FnI-like domain0.01681Inherited
Hect, E3 ligase catalytic domain0.02769Inherited
Insulin-like0.03137Inherited
Arginase/deacetylase0.03137Inherited
Histone-fold0.07Inherited
ARID-like0.07Inherited
TPR-like0.09967Inherited
Nucleotide-diphospho-sugar transferases0.1074Inherited
Hemopexin-like domain0.1135Inherited
BRK domain-like0.1198Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1198Inherited
Restriction endonuclease-like0.1198Inherited
vWA-like0.1359Inherited
HLH, helix-loop-helix DNA-binding domain0.1684Inherited
Metalloproteases ("zincins"), catalytic domain0.1722Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1744Inherited
PGBD-like0.1744Inherited
Cystine-knot cytokines0.2303Inherited
Concanavalin A-like lectins/glucanases0.2592Inherited
GroEL equatorial domain-like0.2643Inherited
p53-like transcription factors0.4344Inherited
HMG-box0.4361Inherited
Cysteine proteinases0.7367Inherited
Immunoglobulin0.7433Inherited
Voltage-gated potassium channels0.9101Inherited
Class II aaRS and biotin synthetases0.9699Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002064Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.04223Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.07Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.07858Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1198Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.1198Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.1744Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1744Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.3489Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.5242Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.6186Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003882Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.07Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.07262Inherited
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.1198Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2976Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)