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Phenotypic Abnormality (PA): Abnormality of movement

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
0:   Abnormality of movement [HP:0100022] <19>(26|25) (28|13|2)
- 1:   Gait disturbance [HP:0001288] <22>(6|6) (10|2|1)
- 1:   Involuntary movements [HP:0004305] <13>(5|3) (5|4|0)
- 1:   Dystonia [HP:0001332] <8>(1|2) (1|1|0)
- 1:   Abnormal reflex [HP:0031826] <5>(8|8) (8|6|1)
- 1:   Dyskinesia [HP:0100660] <3>(1|2) (1|1|0)
- 1:   Muscle fibrillation [HP:0010546] <3>(0|0) (0|0|0)
- 1:   Myokymia [HP:0002411] <3>(0|0) (0|0|0)
- 1:   Abnormal head movements [HP:0002457] <2>(2|2) (2|1|0)
- 1:   Diminished movement [HP:0002374] <2>(0|0) (0|1|0)
- 1:   Cerebral palsy [HP:0100021] <1>(1|1) (1|0|0)
- 1:   Hyperactivity [HP:0000752] <1>(2|4) (3|1|0)
- 1:   Abnormal posturing [HP:0002533](0|0) (0|0|0)
- 1:   Astasia [HP:0020037](0|0) (0|0|0)
- 1:   Asterixis [HP:0012164](0|0) (0|0|0)
- 1:   Bimanual synkinesia [HP:0001335](0|0) (0|0|0)
- 1:   Frontal release signs [HP:0000743](0|0) (0|0|0)
- 1:   Hyperkinetic movements [HP:0002487](0|0) (0|0|0)
- 1:   Postural instability [HP:0002172](0|0) (0|1|0)
- 1:   Stooped posture [HP:0025403](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
CRAL/TRIO domain0Direct
Restriction endonuclease-like0Direct
SNARE fusion complex0Direct
S15/NS1 RNA-binding domain0Direct
HIT-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Actin depolymerizing proteins0Direct
FabD/lysophospholipase-like0.05242Inherited
Nicotinic receptor ligand binding domain-like0.06485Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.06485Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1558Inherited
POZ domain0.1686Inherited
HSP20-like chaperones0.1746Inherited
Acyl-CoA N-acyltransferases (Nat)0.1746Inherited
Voltage-gated potassium channels0.2073Inherited
Arginase/deacetylase0.2476Inherited
Ypt/Rab-GAP domain of gyp1p0.2476Inherited
Cysteine proteinases0.257Inherited
Integrin domains0.4354Inherited
NagB/RpiA/CoA transferase-like0.4666Inherited
Tropomyosin0.5677Inherited
vWA-like0.731Inherited
Bromodomain0.7497Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Ferredoxin domains from multidomain proteins0Direct
XPF/Rad1/Mus81 nuclease0Direct
Anticodon-binding domain0Direct
IF2B-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Lamin A/C globular tail domain0Direct
UBA domain0Direct
SNARE fusion complex0Direct
a tRNA synthase domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Tetramerization domain of potassium channels0.0174Inherited
DNA gyrase/MutL, second domain0.03626Inherited
DNA gyrase/MutL, N-terminal domain0.03626Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.04235Inherited
Nicotinic receptor ligand binding domain-like0.04235Inherited
ZZ domain0.072Inherited
FHA domain0.1182Inherited
Clathrin adaptor core protein0.1369Inherited
Myotubularin-like phosphatases0.2029Inherited
Integrin domains0.3737Inherited
Myosin rod fragments0.4695Inherited
Tropomyosin0.5077Inherited
Integrin A (or I) domain0.5254Inherited
Bromodomain0.6938Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
S15/NS1 RNA-binding domain0Direct
CRAL/TRIO domain0Direct
Lamin A/C globular tail domain0Direct
SNARE fusion complex0Direct
Restriction endonuclease-like0Direct
HIT-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Actin depolymerizing proteins0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
FabD/lysophospholipase-like0.03916Inherited
Nicotinic receptor ligand binding domain-like0.04939Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.04939Inherited
GST C-terminal domain-like0.09838Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1283Inherited
POZ domain0.1393Inherited
HSP20-like chaperones0.1446Inherited
Acyl-CoA N-acyltransferases (Nat)0.1446Inherited
Voltage-gated potassium channels0.1747Inherited
Ypt/Rab-GAP domain of gyp1p0.2118Inherited
Arginase/deacetylase0.2118Inherited
Cysteine proteinases0.2207Inherited
Integrin domains0.3924Inherited
NagB/RpiA/CoA transferase-like0.4235Inherited
Myosin rod fragments0.4895Inherited
Tropomyosin0.5255Inherited
vWA-like0.6938Inherited
Bromodomain0.7135Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.03916Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.04939Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.06652Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.1283Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.1283Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1795Inherited
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0.2118Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.09265Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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