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Mammalian Phenotype (MP): abnormal leukocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
0:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
- 1:   abnormal dendritic cell number [MP:0008125] <7>(2|4) (2|1|0)
- 1:   abnormal granulocyte number [MP:0020201] <6>(3|7) (5|6|2)
- 1:   abnormal lymphocyte cell number [MP:0000717] <6>(18|38) (25|21|9)
- 1:   decreased leukocyte cell number [MP:0000221] <5>(17|28) (24|18|10)
- 1:   increased leukocyte cell number [MP:0000218] <5>(9|23) (15|11|7)
- 1:   abnormal monocyte cell number [MP:0012441] <4>(1|1) (1|1|0)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(5|7) (5|1|0)
- 1:   abnormal plasmacytoid dendritic cell number [MP:0008123] <2>(1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
L30e-like0.001247Inherited
DNA polymerase beta, N-terminal domain-like0.003689Inherited
Flavoproteins0.00405Inherited
Toll/Interleukin receptor TIR domain0.005299Inherited
DEATH domain0.006434Inherited
Ran binding protein zinc finger-like0.01098Inherited
Triple coiled coil domain of C-type lectins0.01269Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01397Inherited
Bcl-2 inhibitors of programmed cell death0.01958Inherited
E2F-DP heterodimerization region0.02705Inherited
p53-like transcription factors0.03934Inherited
TIMP-like0.0569Inherited
SH2 domain0.0654Inherited
Cysteine-rich domain0.0858Inherited
TNF receptor-like0.0858Inherited
Integrin domains0.1341Inherited
DBL homology domain (DH-domain)0.1473Inherited
MHC antigen-recognition domain0.1799Inherited
Nuclear receptor ligand-binding domain0.2014Inherited
Integrin alpha N-terminal domain0.2402Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3Inherited
Riboflavin synthase domain-like0.3Inherited
Calponin-homology domain, CH-domain0.3619Inherited
WWE domain0.5742Inherited
SMAD/FHA domain0.6983Inherited
Terpenoid cyclases/Protein prenyltransferases0.7765Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
BAFF receptor-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
DNA polymerase beta-like0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
RUNT domain0Direct
C1 set domains (antibody constant domain-like)0.0000003123Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00006233Direct
Pyrin domain, PYD0.000167Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0004804Direct
ets domain0.001047Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001401Inherited
Interleukin-1 (IL-1)0.002476Inherited
DNA polymerase beta, N-terminal domain-like0.002476Inherited
Pointed domain0.002769Inherited
Ran binding protein zinc finger-like0.008147Inherited
Toll/Interleukin receptor TIR domain0.008522Inherited
E2F dimerization segment0.008945Inherited
Cytochrome p450 reductase N-terminal domain-like0.009024Inherited
Triple coiled coil domain of C-type lectins0.009024Inherited
Tissue inhibitor of metalloproteinases, TIMP0.009024Inherited
Bcl-2 inhibitors of programmed cell death0.0146Inherited
Interferon regulatory factor0.0146Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.02032Inherited
NADPH-cytochrome p450 reductase-like0.02684Inherited
Nuclear receptor coactivator interlocking domain0.02684Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02684Inherited
Pleckstrin-homology domain (PH domain)0.03392Inherited
SH2 domain0.05004Inherited
CCCH zinc finger0.0585Inherited
Cell cycle transcription factor e2f-dp0.05925Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.08818Inherited
DEATH domain, DD0.1085Inherited
TNF receptor-like0.1085Inherited
Integrin domains0.1085Inherited
MATH domain0.1183Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1274Inherited
PLC-like (P variant)0.1274Inherited
DBL homology domain (DH-domain)0.1315Inherited
SH3-domain0.1351Inherited
MHC antigen-recognition domain0.1494Inherited
Nuclear receptor ligand-binding domain0.17Inherited
Nuclear receptor0.17Inherited
V set domains (antibody variable domain-like)0.2227Inherited
Calponin-homology domain, CH-domain0.3425Inherited
Short-chain cytokines0.4012Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5022Inherited
WWE domain0.535Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
L30e-like0.0006896Direct
DNA polymerase beta, N-terminal domain-like0.002166Inherited
Flavoproteins0.00239Inherited
Toll/Interleukin receptor TIR domain0.003185Inherited
DEATH domain0.003916Inherited
Ran binding protein zinc finger-like0.006907Inherited
Triple coiled coil domain of C-type lectins0.008064Inherited
NAD kinase/diacylglycerol kinase-like0.008942Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008942Inherited
Bcl-2 inhibitors of programmed cell death0.01282Inherited
E2F-DP heterodimerization region0.01819Inherited
Nuclear receptor coactivator interlocking domain0.02455Inherited
p53-like transcription factors0.02724Inherited
TIMP-like0.04072Inherited
SH2 domain0.0475Inherited
CCCH zinc finger0.05297Inherited
beta-beta-alpha zinc fingers0.05416Inherited
TNF receptor-like0.06375Inherited
Cysteine-rich domain0.06375Inherited
Integrin domains0.1048Inherited
DBL homology domain (DH-domain)0.1162Inherited
SH3-domain0.1304Inherited
MHC antigen-recognition domain0.1451Inherited
Nuclear receptor ligand-binding domain0.1645Inherited
Integrin alpha N-terminal domain0.2006Inherited
Riboflavin synthase domain-like0.2568Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2568Inherited
Calponin-homology domain, CH-domain0.3162Inherited
WWE domain0.5278Inherited
Protein kinase-like (PK-like)0.555Inherited
Acyl-CoA N-acyltransferases (Nat)0.6559Inherited
SMAD/FHA domain0.6572Inherited
C-type lectin-like0.6578Inherited
Terpenoid cyclases/Protein prenyltransferases0.7399Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00003724Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000492Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0005588Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0006896Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.002046Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.008064Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01819Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01819Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.03358Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.05402Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.08988Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1104Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1198Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1705Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1741Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2354Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2354Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2415Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.4473Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.4489Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5234Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001159Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01819Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03358Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2354Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3129Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5124Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5278Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.5278Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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