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Mammalian Phenotype (MP): abnormal digestive system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   digestive/alimentary phenotype [MP:0005381] <2>(38|46) (40|19|9)
0:   abnormal digestive system morphology [MP:0000462] <21>(30|38) (31|13|3)
- 1:   abnormal stomach morphology [MP:0000470] <20>(6|6) (6|1|0)
- 1:   abnormal intestine morphology [MP:0000477] <17>(10|14) (11|9|2)
- 1:   abnormal esophagus morphology [MP:0000467] <14>(2|2) (2|1|0)
- 1:   abnormal tongue morphology [MP:0000762] <12>(2|2) (2|1|0)
- 1:   abnormal palate morphology [MP:0003755] <10>(4|7) (4|0|1)
- 1:   abnormal digestive system development [MP:0003119] <9>(3|3) (3|1|0)
- 1:   abnormal salivary gland morphology [MP:0000613] <9>(2|2) (2|1|0)
- 1:   abnormal mucosal lining of the mouth [MP:0003745] <6>(0|0) (0|0|0)
- 1:   abnormal anal canal morphology [MP:0009053] <5>(1|2) (1|0|0)
- 1:   abnormal exocrine pancreas morphology [MP:0005220] <5>(2|2) (2|0|0)
- 1:   decreased alimentary system tumor incidence [MP:0012424] <4>(0|0) (0|0|0)
- 1:   abnormal enteroendocrine cell morphology [MP:0004141] <3>(0|0) (0|0|0)
- 1:   abnormal perineum morphology [MP:0003315] <3>(0|0) (0|0|0)
- 1:   increased alimentary system tumor incidence [MP:0010292] <3>(3|5) (3|2|0)
- 1:   abnormal digestive organ placement [MP:0003283] <2>(0|0) (0|0|0)
- 1:   abnormal throat morphology [MP:0010370] <2>(0|0) (0|0|0)
- 1:   gastrointestinal tract polyps [MP:0010352] <2>(0|0) (0|0|0)
- 1:   gastrointestinal ulcer [MP:0003300] <2>(3|3) (3|3|1)
- 1:   abnormal interstitial cell of Cajal morphology [MP:0009536] <1>(0|0) (0|0|0)
- 1:   gastrointestinal arteriovenous malformation [MP:0010531](0|0) (0|0|0)
- 1:   lymphomesenteric cysts [MP:0003295](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Hedgehog/intein (Hint) domain0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/DD-peptidase0Direct
SMAD MH1 domain0.00008029Direct
HMG-box0.0004621Direct
Homeodomain-like0.0007253Direct
Notch domain0.009134Inherited
DNA repair protein MutS, domain III0.009134Inherited
Trefoil0.01884Inherited
Calponin-homology domain, CH-domain0.02416Inherited
Intermediate filament protein, coiled coil region0.02961Inherited
Flavoproteins0.03217Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.05099Inherited
Cystine-knot cytokines0.08802Inherited
p53-like transcription factors0.1005Inherited
SMAD/FHA domain0.1212Inherited
Growth factor receptor domain0.2079Inherited
Nuclear receptor ligand-binding domain0.2129Inherited
FnI-like domain0.23Inherited
Rhodanese/Cell cycle control phosphatase0.2824Inherited
"Winged helix" DNA-binding domain0.3516Inherited
HLH, helix-loop-helix DNA-binding domain0.403Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4861Inherited
Riboflavin synthase domain-like0.4861Inherited
DBL homology domain (DH-domain)0.6313Inherited
RING/U-box0.7514Inherited
Kringle-like0.8275Inherited
4-helical cytokines0.8313Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Hedgehog (development protein), N-terminal signaling domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 DNA-binding domain-like0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
p53 tetramerization domain0Direct
SMAD domain0.00005919Direct
SMAD MH1 domain0.00005919Direct
HMG-box0.0004597Direct
T-box0.0007703Direct
Homeodomain0.001173Inherited
Cytochrome p450 reductase N-terminal domain-like0.002133Inherited
VWC domain0.003272Inherited
Notch domain0.007108Inherited
DNA repair protein MutS, domain III0.007108Inherited
NADPH-cytochrome p450 reductase-like0.007108Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.007108Inherited
Paired domain0.01335Inherited
Pyridoxal-dependent decarboxylase0.01529Inherited
Trefoil0.01529Inherited
Short-chain cytokines0.01539Inherited
Calponin-homology domain, CH-domain0.02384Inherited
Ephrin ectodomain0.02674Inherited
Intermediate filament protein, coiled coil region0.02878Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.05521Inherited
Nuclear receptor0.06411Inherited
Transforming growth factor (TGF)-beta0.07566Inherited
Cell cycle control phosphatase, catalytic domain0.1034Inherited
Nuclear receptor ligand-binding domain0.1877Inherited
Forkhead DNA-binding domain0.2852Inherited
HLH, helix-loop-helix DNA-binding domain0.3769Inherited
Classic zinc finger, C2H20.5019Inherited
Interferons/interleukin-10 (IL-10)0.5307Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.5513Inherited
EGF-type module0.5649Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.6124Inherited
DBL homology domain (DH-domain)0.6428Inherited
Kringle modules0.9003Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Hedgehog/intein (Hint) domain0Direct
Hedgehog/DD-peptidase0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
SMAD MH1 domain0.00003841Direct
HMG-box0.0002426Direct
Homeodomain-like0.0003886Direct
Notch domain0.005663Inherited
DNA repair protein MutS, domain III0.005663Inherited
Trefoil0.01229Inherited
Calponin-homology domain, CH-domain0.01609Inherited
Intermediate filament protein, coiled coil region0.02012Inherited
Flavoproteins0.022Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.03603Inherited
Cystine-knot cytokines0.06562Inherited
p53-like transcription factors0.07587Inherited
SMAD/FHA domain0.09353Inherited
Growth factor receptor domain0.1704Inherited
Nuclear receptor ligand-binding domain0.1751Inherited
FnI-like domain0.1911Inherited
Rhodanese/Cell cycle control phosphatase0.2402Inherited
"Winged helix" DNA-binding domain0.3062Inherited
HLH, helix-loop-helix DNA-binding domain0.3562Inherited
Riboflavin synthase domain-like0.4385Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4385Inherited
EGF/Laminin0.451Inherited
DBL homology domain (DH-domain)0.5869Inherited
RING/U-box0.7132Inherited
Kringle-like0.7947Inherited
4-helical cytokines0.7988Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0001314Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.002676Inherited
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0.005663Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.005663Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.007864Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1154Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.3145Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.5468Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.5971Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.9299Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001671Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.08757Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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