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Mammalian Phenotype (MP): abnormal liver physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   liver/biliary system phenotype [MP:0005370] <2>(37|39) (41|19|10)
+ 1:   abnormal hepatobiliary system physiology [MP:0002139] <4>(16|14) (16|10|7)
0:   abnormal liver physiology [MP:0000609] <9>(13|11) (13|9|7)
- 1:   abnormal hepatocyte physiology [MP:0010080] <4>(1|1) (1|0|0)
- 1:   abnormal liver regeneration [MP:0002658] <2>(0|0) (0|0|0)
- 1:   abnormal oval cell physiology [MP:0010042](0|0) (0|0|0)
- 1:   decreased liver function [MP:0003325](0|0) (0|0|0)
- 1:   intrahepatic cholestasis [MP:0005415](0|0) (0|0|0)
- 1:   jaundice [MP:0000611](1|0) (1|0|0)
- 1:   liver failure [MP:0003326](0|0) (0|0|0)
- 1:   liver inflammation [MP:0001860](0|0) (0|0|0)
- 1:   portal hypertension [MP:0003328](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53-like transcription factors0.000003197Direct
STAT0.00000343Direct
Transcription factor STAT-4 N-domain0.00000343Direct
Alpha-macroglobulin receptor domain0.0001293Direct
4-helical cytokines0.0001906Direct
C-type lectin-like0.0003383Direct
TNF receptor-like0.0004944Direct
DEATH domain0.0007398Direct
Kringle-like0.0008745Direct
Terpenoid cyclases/Protein prenyltransferases0.0009044Direct
SH2 domain0.0009473Direct
Leucine zipper domain0.001317Inherited
lambda repressor-like DNA-binding domains0.09165Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Rel/Dorsal transcription factors, DNA-binding domain0.000001921Direct
STAT DNA-binding domain0.000002418Direct
STAT0.000002418Direct
Transcription factor STAT-4 N-domain0.000002418Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00003382Direct
Complement components0.00009164Direct
Alpha-macroglobulin receptor domain0.00009164Direct
DEATH domain, DD0.0005353Direct
TNF receptor-like0.0008162Direct
SH2 domain0.0009911Direct
Leucine zipper domain0.001206Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53-like transcription factors0.000001352Direct
STAT0.000001455Direct
Transcription factor STAT-4 N-domain0.000001455Direct
Alpha-macroglobulin receptor domain0.00006392Direct
4-helical cytokines0.00009593Direct
C-type lectin-like0.000176Direct
TNF receptor-like0.0002607Direct
DEATH domain0.000397Direct
Kringle-like0.0004733Direct
Terpenoid cyclases/Protein prenyltransferases0.0004908Direct
SH2 domain0.0005149Direct
Leucine zipper domain0.0007322Direct
lambda repressor-like DNA-binding domains0.06864Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000001084Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000001455Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000001455Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.000001455Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000009779Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.000146Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0002829Direct
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0.000666Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000001455Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000001455Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000274Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.000666Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.000666Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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