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Mammalian Phenotype (MP): abnormal immune system cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system morphology [MP:0000685] <3>(51|76) (60|35|18)
0:   abnormal immune system cell morphology [MP:0000716] <5>(38|63) (48|29|16)
- 1:   abnormal leukocyte morphology [MP:0008246] <4>(37|62) (47|29|15)
- 1:   abnormal leukopoiesis [MP:0005460] <3>(19|28) (21|18|8)
- 1:   abnormal professional antigen presenting cell morphology [MP:0008195] <3>(17|32) (20|11|5)
- 1:   abnormal follicular dendritic cell morphology [MP:0008196] <2>(0|0) (0|0|0)
- 1:   abnormal large unstained cell number [MP:0012360] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
TNF receptor-like0.00000001144Direct
Interleukin 8-like chemokines0.0000312Direct
L30e-like0.002416Inherited
Immunoglobulin0.00431Inherited
DNA polymerase beta, N-terminal domain-like0.005953Inherited
Flavoproteins0.006991Inherited
Toll/Interleukin receptor TIR domain0.01282Inherited
BRCT domain0.01282Inherited
Terpenoid cyclases/Protein prenyltransferases0.01363Inherited
Triple coiled coil domain of C-type lectins0.01814Inherited
Ran binding protein zinc finger-like0.02149Inherited
E2F-DP heterodimerization region0.04044Inherited
SH2 domain0.05128Inherited
SH3-domain0.06478Inherited
TIMP-like0.09745Inherited
SET domain0.1208Inherited
WWE domain0.1417Inherited
Integrin domains0.1809Inherited
DEATH domain0.218Inherited
DBL homology domain (DH-domain)0.2556Inherited
Cysteine-rich domain0.2743Inherited
SMAD/FHA domain0.2751Inherited
Integrin alpha N-terminal domain0.2965Inherited
p53-like transcription factors0.3153Inherited
Nucleotidyltransferase0.3358Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.4306Inherited
Bcl-2 inhibitors of programmed cell death0.4879Inherited
Calponin-homology domain, CH-domain0.5102Inherited
Riboflavin synthase domain-like0.6249Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.6249Inherited
MHC antigen-recognition domain0.6923Inherited
Nuclear receptor ligand-binding domain0.7242Inherited
DNA/RNA polymerases0.9512Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
RUNT domain0Direct
DNA polymerase beta-like0Direct
BAFF receptor-like0Direct
Transcription factor STAT-4 N-domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
STAT0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
TNF receptor-like0.00000006433Direct
Interleukin 8-like chemokines0.00002032Direct
Interleukin-1 (IL-1)0.004083Inherited
DNA polymerase beta, N-terminal domain-like0.004083Inherited
Interferons/interleukin-10 (IL-10)0.004591Inherited
Pointed domain0.004901Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01316Inherited
beta-glycanases0.01316Inherited
Triple coiled coil domain of C-type lectins0.01316Inherited
Cytochrome p450 reductase N-terminal domain-like0.01316Inherited
E2F dimerization segment0.01405Inherited
Ran binding protein zinc finger-like0.01638Inherited
V set domains (antibody variable domain-like)0.01783Inherited
Toll/Interleukin receptor TIR domain0.01892Inherited
Interferon regulatory factor0.02405Inherited
C2 set domains0.02405Inherited
Pleckstrin-homology domain (PH domain)0.02954Inherited
SH2 domain0.03797Inherited
NADPH-cytochrome p450 reductase-like0.03814Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.03814Inherited
Nuclear receptor coactivator interlocking domain0.03814Inherited
Tetraspanin0.03814Inherited
SH3-domain0.04953Inherited
Myb/SANT domain0.06516Inherited
WWE domain0.07438Inherited
Cell cycle transcription factor e2f-dp0.08651Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1194Inherited
DEATH domain, DD0.131Inherited
Integrin domains0.1501Inherited
ets domain0.1723Inherited
Short-chain cytokines0.2263Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.2263Inherited
DBL homology domain (DH-domain)0.2358Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.2591Inherited
C1 set domains (antibody constant domain-like)0.2941Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.2974Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3611Inherited
Long-chain cytokines0.3902Inherited
Pyrin domain, PYD0.3902Inherited
CCCH zinc finger0.4475Inherited
Bcl-2 inhibitors of programmed cell death0.4475Inherited
FHA domain0.4539Inherited
Calponin-homology domain, CH-domain0.4912Inherited
Caspase recruitment domain, CARD0.5125Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.5125Inherited
PLC-like (P variant)0.5743Inherited
MHC antigen-recognition domain0.6574Inherited
Nuclear receptor ligand-binding domain0.6909Inherited
Nuclear receptor0.6909Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.7845Inherited
MATH domain0.7986Inherited
DNA polymerase I0.8555Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.000000004345Direct
Interleukin 8-like chemokines0.00001435Direct
L30e-like0.001385Inherited
Immunoglobulin0.002553Inherited
DNA polymerase beta, N-terminal domain-like0.003594Inherited
Flavoproteins0.004279Inherited
BRCT domain0.008152Inherited
Toll/Interleukin receptor TIR domain0.008152Inherited
Terpenoid cyclases/Protein prenyltransferases0.008708Inherited
TNF-like0.01127Inherited
Triple coiled coil domain of C-type lectins0.01183Inherited
Ran binding protein zinc finger-like0.01418Inherited
NAD kinase/diacylglycerol kinase-like0.01616Inherited
E2F-DP heterodimerization region0.02812Inherited
Nuclear receptor coactivator interlocking domain0.03505Inherited
SH2 domain0.03626Inherited
C-type lectin-like0.04022Inherited
SH3-domain0.04701Inherited
TIMP-like0.07339Inherited
SET domain0.09316Inherited
WWE domain0.1113Inherited
Integrin domains0.146Inherited
(Trans)glycosidases0.1676Inherited
DEATH domain0.18Inherited
DBL homology domain (DH-domain)0.2149Inherited
Cysteine-rich domain0.2326Inherited
SMAD/FHA domain0.2334Inherited
Integrin alpha N-terminal domain0.2534Inherited
p53-like transcription factors0.2712Inherited
Nucleotidyltransferase0.2908Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3836Inherited
beta-beta-alpha zinc fingers0.434Inherited
CCCH zinc finger0.4403Inherited
Bcl-2 inhibitors of programmed cell death0.4403Inherited
Calponin-homology domain, CH-domain0.4627Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5265Inherited
Riboflavin synthase domain-like0.5802Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5802Inherited
MHC antigen-recognition domain0.651Inherited
Nuclear receptor ligand-binding domain0.6846Inherited
Acyl-CoA N-acyltransferases (Nat)0.7565Inherited
Protein kinase-like (PK-like)0.7764Inherited
DNA/RNA polymerases0.9299Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.00000002451Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000009135Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000000288Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.001044Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.001044Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.001385Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.01183Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.01183Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.02812Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02958Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.0506Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1601Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1726Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.2912Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2912Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2912Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3836Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.4321Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.5053Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.6338Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.6361Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.7929Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000003975Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002662Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.003594Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.01183Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.0506Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2912Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3871Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.5053Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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