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Mammalian Phenotype (MP): abnormal lymphocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + + 4:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + 3:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + 3:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + 2:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
+ + 2:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ + 2:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|57) (41|28|14)
+ 1:   abnormal lymphocyte morphology [MP:0002619] <5>(27|46) (33|26|14)
+ 1:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
0:   abnormal lymphocyte cell number [MP:0000717] <6>(18|38) (25|21|9)
- 1:   abnormal T cell number [MP:0006387] <11>(8|22) (16|15|7)
- 1:   abnormal B cell number [MP:0002458] <6>(7|18) (8|8|4)
- 1:   abnormal NK cell number [MP:0008043] <6>(0|0) (0|0|0)
- 1:   decreased lymphocyte cell number [MP:0005016] <5>(16|28) (22|16|7)
- 1:   increased lymphocyte cell number [MP:0005013] <4>(3|12) (8|6|6)
- 1:   abnormal T cell compartment [MP:0013887] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
TNF receptor-like0.000000000242Direct
DNA polymerase beta, N-terminal domain-like0.00113Inherited
SH2 domain0.003875Inherited
Bcl-2 inhibitors of programmed cell death0.005762Inherited
E2F-DP heterodimerization region0.009721Inherited
DEATH domain0.01187Inherited
WWE domain0.05203Inherited
MHC antigen-recognition domain0.08404Inherited
Integrin alpha N-terminal domain0.1336Inherited
Ran binding protein zinc finger-like0.168Inherited
Cysteine-rich domain0.2046Inherited
Toll/Interleukin receptor TIR domain0.2588Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.264Inherited
DBL homology domain (DH-domain)0.3752Inherited
Calponin-homology domain, CH-domain0.5605Inherited
Integrin domains0.5958Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
BAFF receptor-like0Direct
DNA polymerase beta-like0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
RUNT domain0Direct
TNF receptor-like0.000000006597Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000006265Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00004739Direct
DEATH domain, DD0.0001665Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0001872Direct
Pointed domain0.000687Direct
DNA polymerase beta, N-terminal domain-like0.0007484Direct
E2F dimerization segment0.002923Inherited
SH2 domain0.00345Inherited
Bcl-2 inhibitors of programmed cell death0.0042Inherited
Interferon regulatory factor0.0042Inherited
SH3-domain0.005903Inherited
PLC-like (P variant)0.006107Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.007136Inherited
Nuclear receptor coactivator interlocking domain0.01151Inherited
Cell cycle transcription factor e2f-dp0.02313Inherited
WWE domain0.02408Inherited
C1 set domains (antibody constant domain-like)0.02553Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.0414Inherited
MATH domain0.05041Inherited
MHC antigen-recognition domain0.07073Inherited
Pleckstrin-homology domain (PH domain)0.07169Inherited
Ran binding protein zinc finger-like0.1473Inherited
ets domain0.1966Inherited
V set domains (antibody variable domain-like)0.2494Inherited
Toll/Interleukin receptor TIR domain0.2859Inherited
CCCH zinc finger0.3039Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.3441Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3563Inherited
DBL homology domain (DH-domain)0.3563Inherited
Calponin-homology domain, CH-domain0.541Inherited
Integrin domains0.5798Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
TNF receptor-like0.00000000008862Direct
DNA polymerase beta, N-terminal domain-like0.0006214Direct
SH2 domain0.002281Inherited
Bcl-2 inhibitors of programmed cell death0.003473Inherited
SH3-domain0.003521Inherited
E2F-DP heterodimerization region0.00606Inherited
DEATH domain0.007513Inherited
Nuclear receptor coactivator interlocking domain0.009986Inherited
p53-like transcription factors0.01942Inherited
WWE domain0.03683Inherited
beta-beta-alpha zinc fingers0.04946Inherited
MHC antigen-recognition domain0.06232Inherited
Integrin alpha N-terminal domain0.1044Inherited
Ran binding protein zinc finger-like0.1344Inherited
Cysteine-rich domain0.1674Inherited
Toll/Interleukin receptor TIR domain0.2179Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2227Inherited
CCCH zinc finger0.2866Inherited
DBL homology domain (DH-domain)0.3292Inherited
Acyl-CoA N-acyltransferases (Nat)0.4086Inherited
Protein kinase-like (PK-like)0.4411Inherited
Calponin-homology domain, CH-domain0.514Inherited
Integrin domains0.5502Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000001289Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000004265Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0001191Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0001191Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0003868Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.00606Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.00606Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.02005Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.02672Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.04915Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.05648Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.06232Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1344Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.1344Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.2866Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3292Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.3682Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00606Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1344Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3682Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3682Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.3682Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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