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Mammalian Phenotype (MP): abnormal immune cell physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
- 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
- 1:   abnormal follicular dendritic cell physiology [MP:0008197] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
SH2 domain0.00004409Direct
Immunoglobulin0.00006185Direct
DEATH domain0.0001561Direct
SH3-domain0.0001567Direct
p53-like transcription factors0.003038Inherited
DBL homology domain (DH-domain)0.01813Inherited
Toll/Interleukin receptor TIR domain0.03002Inherited
TNF receptor-like0.03292Inherited
Caspase-like0.05634Inherited
MHC antigen-recognition domain0.0567Inherited
Flavoproteins0.07591Inherited
Interleukin 8-like chemokines0.1004Inherited
L30e-like0.1099Inherited
Bcl-2 inhibitors of programmed cell death0.1378Inherited
Cysteine-rich domain0.1398Inherited
Inhibitor of apoptosis (IAP) repeat0.1842Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2449Inherited
4-helical cytokines0.2616Inherited
E set domains0.2709Inherited
Integrin domains0.3069Inherited
WWE domain0.3264Inherited
TNF-like0.335Inherited
Integrin beta tail domain0.4747Inherited
Integrin alpha N-terminal domain0.4935Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.564Inherited
C-type lectin-like0.5736Inherited
SMAD/FHA domain0.6199Inherited
Family A G protein-coupled receptor-like0.6537Inherited
vWA-like0.7925Inherited
Complement control module/SCR domain0.8826Inherited
L domain-like0.9958Inherited
EGF/Laminin1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT DNA-binding domain0Direct
STAT0Direct
Cysteine rich domain0Direct
Transcription factor STAT-4 N-domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000006147Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000171Direct
SH2 domain0.00002112Direct
Pyrin domain, PYD0.00007356Direct
SH3-domain0.00007895Direct
Inhibitor of apoptosis (IAP) repeat0.0003316Direct
28-residue LRR0.0007207Direct
Pleckstrin-homology domain (PH domain)0.002455Inherited
C1 set domains (antibody constant domain-like)0.005243Inherited
Cytochrome p450 reductase N-terminal domain-like0.005893Inherited
V set domains (antibody variable domain-like)0.006613Inherited
DBL homology domain (DH-domain)0.01575Inherited
NADPH-cytochrome p450 reductase-like0.01823Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01823Inherited
Caspase recruitment domain, CARD0.02102Inherited
Toll/Interleukin receptor TIR domain0.02716Inherited
TNF receptor-like0.04132Inherited
MHC antigen-recognition domain0.04132Inherited
Caspase catalytic domain0.05731Inherited
DEATH domain, DD0.07692Inherited
Interleukin 8-like chemokines0.07692Inherited
I set domains0.07884Inherited
ets domain0.09044Inherited
Short-chain cytokines0.0962Inherited
Bcl-2 inhibitors of programmed cell death0.1102Inherited
PLC-like (P variant)0.1188Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2103Inherited
C-type lectin domain0.2547Inherited
Integrin domains0.2657Inherited
Interferon regulatory factor0.269Inherited
WWE domain0.2853Inherited
TNF-like0.2917Inherited
Integrin alpha N-terminal domain0.3671Inherited
Rhodopsin-like0.4181Inherited
FHA domain0.4218Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.4311Inherited
Integrin beta EGF-like domains0.4311Inherited
Integrin beta tail domain0.4311Inherited
Interleukin 17F, IL-17F0.5362Inherited
Integrin A (or I) domain0.6435Inherited
Complement control module/SCR domain0.8585Inherited
EGF-type module0.9829Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
SH2 domain0.00002058Direct
Immunoglobulin0.00002921Direct
DEATH domain0.00007799Direct
SH3-domain0.00007826Direct
p53-like transcription factors0.001762Inherited
DBL homology domain (DH-domain)0.01182Inherited
Toll/Interleukin receptor TIR domain0.02042Inherited
TNF receptor-like0.02253Inherited
Caspase-like0.04025Inherited
MHC antigen-recognition domain0.04057Inherited
Flavoproteins0.05586Inherited
Interleukin 8-like chemokines0.07583Inherited
L30e-like0.08392Inherited
Bcl-2 inhibitors of programmed cell death0.1081Inherited
Cysteine-rich domain0.1097Inherited
RNI-like0.1172Inherited
Inhibitor of apoptosis (IAP) repeat0.1491Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2051Inherited
4-helical cytokines0.2204Inherited
E set domains0.2293Inherited
Integrin domains0.2632Inherited
WWE domain0.282Inherited
TNF-like0.2901Inherited
Integrin beta tail domain0.427Inherited
Integrin alpha N-terminal domain0.4458Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5174Inherited
C-type lectin-like0.5271Inherited
SMAD/FHA domain0.5748Inherited
Family A G protein-coupled receptor-like0.6105Inherited
vWA-like0.7573Inherited
Transducin (alpha subunit), insertion domain0.7684Inherited
Complement control module/SCR domain0.8544Inherited
L domain-like0.9817Inherited
EGF/Laminin0.995Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000003926Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0002678Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003005Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.004273Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.00506Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.01215Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01779Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0205Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02253Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.03305Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.09443Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1081Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1491Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1491Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.1491Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2051Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.2051Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2174Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.282Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3636Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3636Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.427Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.427Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6224Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8039Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00506Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.00506Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0205Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0269Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2051Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2051Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.282Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.282Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3636Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.427Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4406Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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