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Mammalian Phenotype (MP): abnormal tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ 1:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
0:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
- 1:   abnormal classified tumor incidence [MP:0020188] <3>(20|19) (26|7|1)
- 1:   decreased tumor incidence [MP:0002052] <3>(0|1) (0|1|0)
- 1:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
- 1:   abnormal incidence of induced tumors [MP:0013151] <2>(1|1) (1|1|0)
- 1:   abnormal organ/body region tumor incidence [MP:0013152] <2>(21|24) (24|8|3)
- 1:   embryo tumor [MP:0014018](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.00002007Direct
DNA/RNA polymerases0.00007385Direct
Bcl-2 inhibitors of programmed cell death0.0009124Direct
SPOC domain-like0.0014Inherited
DNA-glycosylase0.0014Inherited
Restriction endonuclease-like0.0014Inherited
Nucleic acid-binding proteins0.001609Inherited
4-helical cytokines0.002022Inherited
RING/U-box0.004494Inherited
Notch domain0.004611Inherited
DNA repair protein MutS, domain III0.004611Inherited
SAND domain-like0.004611Inherited
Putative DNA-binding domain0.0174Inherited
BRCT domain0.02757Inherited
CCCH zinc finger0.08503Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1109Inherited
SET domain0.1407Inherited
ARM repeat0.1487Inherited
Ubiquitin-like0.3726Inherited
Protein kinase-like (PK-like)0.4234Inherited
Intermediate filament protein, coiled coil region0.4787Inherited
SMAD/FHA domain0.9019Inherited
Cyclin-like0.9317Inherited
p53-like transcription factors0.9317Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.00001484Direct
SMAD MH1 domain0.00001484Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00001484Direct
DNA polymerase I0.0006187Direct
Bcl-2 inhibitors of programmed cell death0.000705Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001009Inherited
XPF/Rad1/Mus81 nuclease0.001015Inherited
Pointed domain0.001619Inherited
L domain0.001619Inherited
Notch domain0.003533Inherited
DNA repair protein MutS, domain III0.003533Inherited
p120GAP domain-like0.00961Inherited
Forkhead DNA-binding domain0.01201Inherited
Single strand DNA-binding domain, SSB0.01418Inherited
Pyrin domain, PYD0.01418Inherited
DnaQ-like 3'-5' exonuclease0.02018Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.02668Inherited
Short-chain cytokines0.02716Inherited
Interferons/interleukin-10 (IL-10)0.03284Inherited
Histone lysine methyltransferases0.04974Inherited
CCCH zinc finger0.07554Inherited
FHA domain0.1259Inherited
Protein kinases, catalytic subunit0.4183Inherited
Phosphotyrosine-binding domain (PTB)0.4635Inherited
Intermediate filament protein, coiled coil region0.4839Inherited
ABC transporter ATPase domain-like0.4988Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000008985Direct
DNA/RNA polymerases0.00003531Direct
Bcl-2 inhibitors of programmed cell death0.0004958Direct
Restriction endonuclease-like0.0007815Direct
SPOC domain-like0.0007815Direct
DNA-glycosylase0.0007815Direct
Nucleic acid-binding proteins0.0009045Direct
4-helical cytokines0.00115Inherited
RING/U-box0.002664Inherited
Notch domain0.002745Inherited
DNA repair protein MutS, domain III0.002745Inherited
SAND domain-like0.002745Inherited
Chromo domain-like0.005287Inherited
Snake toxin-like0.00769Inherited
Putative DNA-binding domain0.01133Inherited
BRCT domain0.01859Inherited
Cysteine-rich domain0.02388Inherited
Ribonuclease H-like0.04473Inherited
CCCH zinc finger0.06314Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.08484Inherited
Leucine zipper domain0.09658Inherited
SET domain0.1105Inherited
ARM repeat0.1176Inherited
Ubiquitin-like0.3267Inherited
Protein kinase-like (PK-like)0.3766Inherited
Intermediate filament protein, coiled coil region0.4311Inherited
SMAD/FHA domain0.8752Inherited
p53-like transcription factors0.9078Inherited
Cyclin-like0.9078Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0007312Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0007815Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001196Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001196Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.002499Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002745Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01823Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.02146Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04515Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1342Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0007815Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001196Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.07804Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)