SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): increased tumor incidence

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + 2:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
0:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
- 1:   increased classified tumor incidence [MP:0010273] <19>(20|19) (26|7|1)
- 1:   increased organ/body region tumor incidence [MP:0010274] <14>(21|24) (24|8|3)
- 1:   increased incidence of induced tumors [MP:0002021] <4>(1|0) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000008952Direct
DNA/RNA polymerases0.00003156Direct
Bcl-2 inhibitors of programmed cell death0.000504Direct
Nucleic acid-binding proteins0.0005985Direct
SPOC domain-like0.0009397Direct
DNA-glycosylase0.0009397Direct
Restriction endonuclease-like0.0009397Direct
SMAD/FHA domain0.0009568Direct
Cyclin-like0.002377Inherited
Notch domain0.003129Inherited
DNA repair protein MutS, domain III0.003129Inherited
SAND domain-like0.003129Inherited
Putative DNA-binding domain0.01229Inherited
BRCT domain0.01634Inherited
p53-like transcription factors0.04774Inherited
CCCH zinc finger0.06318Inherited
SET domain0.09109Inherited
ARM repeat0.1687Inherited
Protein kinase-like (PK-like)0.1702Inherited
RING/U-box0.3007Inherited
4-helical cytokines0.416Inherited
Intermediate filament protein, coiled coil region0.738Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8398Inherited
Ubiquitin-like0.9902Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.000006668Direct
SMAD MH1 domain0.000006668Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.000006668Direct
DNA polymerase I0.0003685Direct
Bcl-2 inhibitors of programmed cell death0.0003849Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0005114Direct
XPF/Rad1/Mus81 nuclease0.0006663Direct
Pointed domain0.0009763Direct
L domain0.0009763Direct
Notch domain0.00235Inherited
DNA repair protein MutS, domain III0.00235Inherited
Forkhead DNA-binding domain0.005623Inherited
p120GAP domain-like0.006066Inherited
Single strand DNA-binding domain, SSB0.009844Inherited
DnaQ-like 3'-5' exonuclease0.01313Inherited
Short-chain cytokines0.01798Inherited
Histone lysine methyltransferases0.03155Inherited
CCCH zinc finger0.05515Inherited
FHA domain0.08986Inherited
Protein kinases, catalytic subunit0.2031Inherited
Phosphotyrosine-binding domain (PTB)0.3698Inherited
ABC transporter ATPase domain-like0.3917Inherited
Intermediate filament protein, coiled coil region0.7061Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.8289Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000003911Direct
DNA/RNA polymerases0.00001452Direct
Bcl-2 inhibitors of programmed cell death0.0002665Direct
Nucleic acid-binding proteins0.0003179Direct
Restriction endonuclease-like0.0005105Direct
SPOC domain-like0.0005105Direct
DNA-glycosylase0.0005105Direct
SMAD/FHA domain0.0005208Direct
Cyclin-like0.001363Inherited
Notch domain0.001821Inherited
DNA repair protein MutS, domain III0.001821Inherited
SAND domain-like0.001821Inherited
Chromo domain-like0.002648Inherited
Putative DNA-binding domain0.007795Inherited
BRCT domain0.01056Inherited
Ribonuclease H-like0.02676Inherited
p53-like transcription factors0.03362Inherited
CCCH zinc finger0.04574Inherited
SET domain0.06811Inherited
ARM repeat0.1349Inherited
Protein kinase-like (PK-like)0.1363Inherited
RING/U-box0.2574Inherited
4-helical cytokines0.369Inherited
Leucine zipper domain0.4853Inherited
Snake toxin-like0.4853Inherited
Intermediate filament protein, coiled coil region0.6992Inherited
Cysteine-rich domain0.7849Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.808Inherited
Ubiquitin-like0.9749Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0002707Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0005105Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0007188Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0007188Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001821Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01258Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.01388Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.09593Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.6992Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0005105Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0007188Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.05688Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)