Mammalian Phenotype (MP): prenatal lethality

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: mammalian phenotype [MP:0000001] <29>

+ + 2: mortality/aging [MP:0010768] <4> (83|115) (89|67|50)

+ 1: abnormal survival [MP:0010769] <10> (60|91) (67|55|39)

+ 1: preweaning lethality [MP:0010770] <4> (48|79) (55|45|38)

0: prenatal lethality [MP:0002080] <5> (27|49) (30|23|16)

- 1: embryonic lethality [MP:0008762] <4> (16|30) (16|11|7)

- 1: lethality throughout fetal growth and development [MP:0006208] <2> (5|8) (6|6|7)

- 1: prenatal lethality prior to heart atrial septation [MP:0013294] (0|0) (0|0|0)

- 1: prenatal lethality, complete penetrance [MP:0011091] (0|2) (0|0|0)

- 1: prenatal lethality, incomplete penetrance [MP:0011101] (2|5) (4|1|1)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
ATP-dependent DNA ligase DNA-binding domain	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	Direct
p53 tetramerization domain	0	Direct
DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
Zinc beta-ribbon	0	Direct
GroEL-intermediate domain like	0	Direct
Ribonuclease PH domain 2-like	0	Direct
"Winged helix" DNA-binding domain	0.0007803	Direct
ARM repeat	0.001415	Inherited
Nucleic acid-binding proteins	0.003415	Inherited
GroEL apical domain-like	0.01053	Inherited
HCP-like	0.01347	Inherited
Protein kinase-like (PK-like)	0.01609	Inherited
BRCT domain	0.01698	Inherited
SCOP hierarchy in SUPERFAMILY	0.02142	Inherited
E2F-DP heterodimerization region	0.05363	Inherited
Flavoproteins	0.06525	Inherited
p53-like transcription factors	0.08255	Inherited
DNA clamp	0.1279	Inherited
SMAD MH1 domain	0.1428	Inherited
ADC-like	0.1947	Inherited
Subtilisin-like	0.2014	Inherited
Cullin homology domain	0.2014	Inherited
TB module/8-cys domain	0.2797	Inherited
dsRNA-binding domain-like	0.3325	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Chromo barrel domain	0	Direct
Pointed domain	0	Direct
DNA ligase/mRNA capping enzyme postcatalytic domain	0	Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	Direct
p53 DNA-binding domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Ribonuclease PH domain 1-like	0	Direct
SMAD4-binding domain of oncoprotein Ski	0	Direct
DNA ligase	0	Direct
Group II chaperonin (CCT, TRIC), apical domain	0	Direct
ATP-dependent DNA ligase catalytic domain	0	Direct
Fumble-like	0	Direct
p53 tetramerization domain	0	Direct
Retinoblastoma tumor suppressor domains	0	Direct
Ribonuclease PH domain 2-like	0	Direct
Cytochrome p450 reductase N-terminal domain-like	0	Direct
SIAH, seven in absentia homolog	0	Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.0002667	Direct
RecA protein-like (ATPase-domain)	0.0005902	Direct
Inhibitor of apoptosis (IAP) repeat	0.002491	Inherited
Extracellular domain of cell surface receptors	0.003997	Inherited
ets domain	0.004541	Inherited
NADPH-cytochrome p450 reductase-like	0.007336	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.007336	Inherited
N-acetyl transferase, NAT	0.00854	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.00854	Inherited
Cell cycle transcription factor e2f-dp	0.01409	Inherited
Histone lysine methyltransferases	0.01747	Inherited
C5 cytosine-specific DNA methylase, DCM	0.02073	Inherited
Proprotein convertase P-domain	0.02397	Inherited
Prohormone convertase 1 pro-domain	0.02397	Inherited
DNA polymerase I	0.02397	Inherited
Erythroid transcription factor GATA-1	0.03788	Inherited
Protein kinases, catalytic subunit	0.03801	Inherited
Adenain-like	0.05773	Inherited
Subtilases	0.06162	Inherited
E2F dimerization segment	0.06162	Inherited
Tandem AAA-ATPase domain	0.08221	Inherited
SCF ubiquitin ligase complex WHB domain	0.09977	Inherited
SMAD MH1 domain	0.1118	Inherited
SMAD domain	0.1118	Inherited
Extended AAA-ATPase domain	0.1322	Inherited
Linker histone H1/H5	0.1326	Inherited
Cullin homology domain	0.1641	Inherited
T-box	0.1679	Inherited
TB module/8-cys domain	0.2369	Inherited
Armadillo repeat	0.2515	Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH	0.75	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Ribonuclease PH domain 2-like	0	Direct
ATP-dependent DNA ligase DNA-binding domain	0	Direct
DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	Direct
GroEL-intermediate domain like	0	Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	Direct
Zinc beta-ribbon	0	Direct
p53 tetramerization domain	0	Direct
"Winged helix" DNA-binding domain	0.0004204	Direct
ARM repeat	0.0007897	Direct
Nucleic acid-binding proteins	0.001993	Inherited
GroEL apical domain-like	0.006602	Inherited
HCP-like	0.008587	Inherited
Inhibitor of apoptosis (IAP) repeat	0.008587	Inherited
Protein kinase-like (PK-like)	0.01039	Inherited
BRCT domain	0.01103	Inherited
E2F-DP heterodimerization region	0.0381	Inherited
Flavoproteins	0.04739	Inherited
Acyl-CoA N-acyltransferases (Nat)	0.05347	Inherited
p53-like transcription factors	0.06111	Inherited
DNA clamp	0.09933	Inherited
SMAD MH1 domain	0.1123	Inherited
ADC-like	0.1585	Inherited
Cullin homology domain	0.1645	Inherited
Subtilisin-like	0.1645	Inherited
Riboflavin synthase domain-like	0.2273	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.2273	Inherited
TB module/8-cys domain	0.2377	Inherited
dsRNA-binding domain-like	0.2878	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57184,82895 57184 - Growth factor receptor domain 82895 - TSP-1 type 1 repeat	0	Direct
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0	Direct
57196,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module	0	Direct
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	Direct
57581,57184 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	Direct
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
46955,63763 46955 - Putative DNA-binding domain 63763 - SAND domain-like	0	Direct
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	Direct
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0.02076	Inherited
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.0214	Inherited
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0.02198	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.0381	Inherited
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.05385	Inherited
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0844	Inherited
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0.09933	Inherited
57581,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0.09933	Inherited
57196,57581 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.09933	Inherited
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like	0.1585	Inherited
52113,52113 52113 - BRCT domain 52113 - BRCT domain	0.1645	Inherited
57184,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases	0.3389	Inherited
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.3912	Inherited
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.3912	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,57581,57184 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	Direct
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	Direct
63825,57196,57424 63825 - YWTD domain 57196 - EGF/Laminin 57424 - LDL receptor-like module	0	Direct
57581,57184,57581 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	Direct
57196,57424,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0	Direct
75399,75399,75399 75399 - Plakin repeat 75399 - Plakin repeat 75399 - Plakin repeat	0	Direct
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	Direct
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0.02076	Inherited
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.02076	Inherited
54897,52743,49785 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0.02198	Inherited
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.05385	Inherited
57184,57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.09933	Inherited
57581,57196,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1585	Inherited
57196,57196,57581 57196 - EGF/Laminin 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.1585	Inherited
57184,49899,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.3389	Inherited
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.3912	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): prenatal lethality

Superfamily

Family

Supra-domain (including individual superfamily)