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Mammalian Phenotype (MP): abnormal brain morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   nervous system phenotype [MP:0003631] <2>(98|128) (113|79|50)
+ 1:   abnormal nervous system morphology [MP:0003632] <17>(76|104) (91|64|47)
0:   abnormal brain morphology [MP:0002152] <24>(25|42) (35|24|14)
- 1:   abnormal brain development [MP:0000913] <15>(6|12) (7|4|1)
- 1:   abnormal midbrain morphology [MP:0000897] <10>(2|4) (2|0|0)
- 1:   abnormal brain vasculature morphology [MP:0004950] <9>(0|0) (0|0|0)
- 1:   abnormal forebrain morphology [MP:0000783] <8>(18|26) (24|15|8)
- 1:   abnormal hindbrain morphology [MP:0000841] <7>(6|9) (7|12|7)
- 1:   abnormal brain size [MP:0000771] <6>(1|1) (2|0|0)
- 1:   abnormal brain ventricular system morphology [MP:0002200] <6>(3|6) (5|1|2)
- 1:   abnormal brain white matter morphology [MP:0008026] <6>(3|9) (5|4|3)
- 1:   abnormal brainstem morphology [MP:0005277] <6>(2|5) (3|0|0)
- 1:   abnormal brain copper level [MP:0011213] <3>(1|1) (1|0|0)
- 1:   brain atrophy [MP:0012506] <3>(0|0) (0|0|0)
- 1:   abnormal brain cholesterol level [MP:0012779] <2>(0|0) (0|0|0)
- 1:   abnormal brain iron level [MP:0008811] <2>(0|0) (0|0|0)
- 1:   abnormal circumventricular organ morphology [MP:0013562] <2>(2|2) (2|0|0)
- 1:   abnormal postnatal subventricular zone morphology [MP:0004275] <1>(0|1) (0|0|0)
- 1:   decreased sulfoglycosphingolipid level [MP:0020005] <1>(0|0) (0|0|0)
- 1:   abnormal brain interneuron morphology [MP:0004101](0|0) (0|0|0)
- 1:   basal brain tissue herniation [MP:0013935](0|0) (0|0|0)
- 1:   brain vacuoles [MP:0008025](0|0) (0|0|0)
- 1:   decreased brain plasmalogen level [MP:0012218](0|0) (0|0|0)
- 1:   increased brain plasmalogen level [MP:0012219](0|0) (0|0|0)
- 1:   increased brain sulfoglycosphingolipid level [MP:0020008](0|0) (0|0|0)
- 1:   neurofibrillary tangles [MP:0003214](0|0) (0|0|0)
- 1:   tau protein deposits [MP:0004250](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
SRF-like0.01149Inherited
HMA, heavy metal-associated domain0.01149Inherited
YWTD domain0.06899Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.09072Inherited
GTPase activation domain, GAP0.1343Inherited
HLH, helix-loop-helix DNA-binding domain0.1857Inherited
Growth factor receptor domain0.2561Inherited
Cyclin-like0.2631Inherited
Cupredoxins0.2912Inherited
Nuclear receptor ligand-binding domain0.3158Inherited
Metallo-dependent hydrolases0.3663Inherited
lambda repressor-like DNA-binding domains0.3983Inherited
EGF/Laminin0.404Inherited
SAP domain0.4308Inherited
Galactose-binding domain-like0.4483Inherited
Plexin repeat0.457Inherited
Sema domain0.461Inherited
Doublecortin (DC)0.5605Inherited
cAMP-binding domain-like0.5615Inherited
SH3-domain0.5854Inherited
Homeodomain-like0.6955Inherited
Family A G protein-coupled receptor-like0.9512Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Other IPT/TIG domains0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
DIX domain0.0005934Direct
SMAD domain0.0007287Direct
SMAD MH1 domain0.0007287Direct
HMA, heavy metal-associated domain0.008504Inherited
Mib/herc2 domain0.008504Inherited
Multidrug efflux transporter AcrB transmembrane domain0.008504Inherited
SRF-like0.008504Inherited
beta-glycanases0.008504Inherited
Bcl-2 inhibitors of programmed cell death0.01347Inherited
Classic zinc finger, C2H20.02921Inherited
YWTD domain0.05309Inherited
Ephrin ectodomain0.1439Inherited
HLH, helix-loop-helix DNA-binding domain0.1587Inherited
POU-specific domain0.1988Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1988Inherited
L domain0.2Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.2Inherited
Cyclin0.2564Inherited
Nuclear receptor ligand-binding domain0.2814Inherited
Nuclear receptor0.2814Inherited
Paired domain0.3291Inherited
EGF-type module0.3674Inherited
SAP domain0.4123Inherited
Plexin repeat0.4208Inherited
Sema domain0.4243Inherited
cAMP-binding domain0.4278Inherited
Phosphotyrosine-binding domain (PTB)0.4296Inherited
SAM (sterile alpha motif) domain0.4296Inherited
Ephrin receptor ligand binding domain0.5145Inherited
Doublecortin (DC)0.5233Inherited
SH3-domain0.554Inherited
Forkhead DNA-binding domain0.6036Inherited
Voltage-gated potassium channels0.6625Inherited
Ngr ectodomain-like0.6974Inherited
Homeodomain0.8135Inherited
Rhodopsin-like0.9503Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
SMAD MH1 domain0.0005677Direct
Glutamine synthetase/guanido kinase0.006954Inherited
Mib/herc2 domain-like0.007256Inherited
HMA, heavy metal-associated domain0.007256Inherited
SRF-like0.007256Inherited
Bcl-2 inhibitors of programmed cell death0.01117Inherited
BRCT domain0.02517Inherited
YWTD domain0.05041Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.06779Inherited
GTPase activation domain, GAP0.105Inherited
Quinoprotein alcohol dehydrogenase-like0.139Inherited
HLH, helix-loop-helix DNA-binding domain0.1504Inherited
E set domains0.2056Inherited
Growth factor receptor domain0.2153Inherited
Cyclin-like0.2218Inherited
Cupredoxins0.2486Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2693Inherited
Nuclear receptor ligand-binding domain0.2717Inherited
Metallo-dependent hydrolases0.3206Inherited
lambda repressor-like DNA-binding domains0.3517Inherited
EGF/Laminin0.3571Inherited
SAP domain0.3838Inherited
Galactose-binding domain-like0.4007Inherited
Plexin repeat0.4092Inherited
Sema domain0.4132Inherited
Voltage-gated potassium channels0.4884Inherited
Doublecortin (DC)0.514Inherited
cAMP-binding domain-like0.515Inherited
SH3-domain0.5392Inherited
Homeodomain-like0.6543Inherited
L domain-like0.9294Inherited
Family A G protein-coupled receptor-like0.9299Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.007256Inherited
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.0161Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02517Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.09961Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.09961Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1026Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.1472Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1938Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1938Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1938Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1938Inherited
    49785,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1938Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.1938Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.4132Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.4181Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.4956Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.505Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.514Inherited
    89837,89837
  • 89837 - Doublecortin (DC)
  • 89837 - Doublecortin (DC)
  • 0.514Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.6078Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.7038Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02517Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03484Inherited
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.09961Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.1472Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.1938Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1938Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1938Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1938Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.2693Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3699Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.514Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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