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Mammalian Phenotype (MP): abnormal leukocyte physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ 1:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ 1:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ 1:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ 1:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
0:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal macrophage physiology [MP:0002451] <10>(7|6) (8|4|2)
- 1:   abnormal leukocyte migration [MP:0003156] <7>(8|9) (8|5|3)
- 1:   abnormal granulocyte physiology [MP:0002462] <6>(3|3) (3|2|1)
- 1:   abnormal lymphocyte physiology [MP:0003945] <4>(21|31) (23|22|13)
- 1:   leukostasis [MP:0008541](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.00000004567Direct
p53-like transcription factors0.0000004901Direct
MHC antigen-recognition domain0.000002688Direct
4-helical cytokines0.00001379Direct
Caspase-like0.00002682Direct
Interleukin 8-like chemokines0.0001229Direct
Cysteine-rich domain0.0004123Direct
Bcl-2 inhibitors of programmed cell death0.001483Inherited
Inhibitor of apoptosis (IAP) repeat0.001921Inherited
Integrin beta tail domain0.01557Inherited
DBL homology domain (DH-domain)0.01574Inherited
DEATH domain0.04285Inherited
E set domains0.05602Inherited
SH2 domain0.07128Inherited
Flavoproteins0.07248Inherited
WWE domain0.07248Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.09023Inherited
L30e-like0.1053Inherited
SMAD/FHA domain0.1399Inherited
SH3-domain0.1451Inherited
Toll/Interleukin receptor TIR domain0.2506Inherited
vWA-like0.3907Inherited
C-type lectin-like0.4395Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.59Inherited
TNF-like0.5983Inherited
L domain-like0.6634Inherited
Integrin domains0.72Inherited
EGF/Laminin0.7648Inherited
Integrin alpha N-terminal domain0.8154Inherited
Family A G protein-coupled receptor-like0.9635Inherited
Complement control module/SCR domain0.9656Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT DNA-binding domain0Direct
STAT0Direct
Cysteine rich domain0Direct
Transcription factor STAT-4 N-domain0Direct
C1 set domains (antibody constant domain-like)0.0000000329Direct
TNF receptor-like0.00000004028Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000005122Direct
MHC antigen-recognition domain0.000001876Direct
Short-chain cytokines0.000004082Direct
Caspase recruitment domain, CARD0.00001043Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00001422Direct
Pyrin domain, PYD0.00006519Direct
Caspase catalytic domain0.00007251Direct
Interleukin 8-like chemokines0.00009074Direct
Inhibitor of apoptosis (IAP) repeat0.0003004Direct
28-residue LRR0.0006229Direct
Bcl-2 inhibitors of programmed cell death0.001032Inherited
Interferon regulatory factor0.001032Inherited
Cytochrome p450 reductase N-terminal domain-like0.005528Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01172Inherited
Integrin beta tail domain0.01172Inherited
DBL homology domain (DH-domain)0.01347Inherited
Interleukin 17F, IL-17F0.01721Inherited
NADPH-cytochrome p450 reductase-like0.01721Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01721Inherited
Integrin beta EGF-like domains0.02205Inherited
WWE domain0.03518Inherited
SH2 domain0.04587Inherited
ets domain0.08369Inherited
SH3-domain0.1024Inherited
Toll/Interleukin receptor TIR domain0.2189Inherited
V set domains (antibody variable domain-like)0.2244Inherited
I set domains0.2244Inherited
DEATH domain, DD0.2825Inherited
FHA domain0.4071Inherited
C-type lectin domain0.412Inherited
Integrin A (or I) domain0.4326Inherited
Pleckstrin-homology domain (PH domain)0.4329Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.5127Inherited
TNF-like0.538Inherited
PLC-like (P variant)0.538Inherited
Integrin domains0.6683Inherited
Integrin alpha N-terminal domain0.8077Inherited
EGF-type module0.8091Inherited
Rhodopsin-like0.9314Inherited
Complement control module/SCR domain0.9461Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.00000001762Direct
p53-like transcription factors0.0000001973Direct
MHC antigen-recognition domain0.000001128Direct
4-helical cytokines0.000006104Direct
Caspase-like0.00001228Direct
Interleukin 8-like chemokines0.00006044Direct
Cysteine-rich domain0.0002161Direct
Bcl-2 inhibitors of programmed cell death0.0008303Direct
Inhibitor of apoptosis (IAP) repeat0.001088Inherited
Integrin beta tail domain0.01002Inherited
DBL homology domain (DH-domain)0.01014Inherited
RNI-like0.01783Inherited
DEATH domain0.02991Inherited
E set domains0.04001Inherited
SH2 domain0.05221Inherited
Flavoproteins0.05319Inherited
WWE domain0.05319Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.06739Inherited
L30e-like0.07999Inherited
SMAD/FHA domain0.1098Inherited
SH3-domain0.1144Inherited
Toll/Interleukin receptor TIR domain0.2103Inherited
vWA-like0.3444Inherited
C-type lectin-like0.3919Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5438Inherited
TNF-like0.5528Inherited
L domain-like0.6208Inherited
Integrin domains0.6803Inherited
EGF/Laminin0.7272Inherited
Integrin alpha N-terminal domain0.7815Inherited
Family A G protein-coupled receptor-like0.9437Inherited
Complement control module/SCR domain0.9461Inherited
Transducin (alpha subunit), insertion domain0.9844Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000003262Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000005338Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000005311Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.000006836Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000007927Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0002419Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0002419Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0002419Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002682Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0008303Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.004758Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.006375Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01002Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01002Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01506Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01536Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0313Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2824Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5528Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.6668Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.6668Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.8149Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.8149Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9739Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.9844Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00008831Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001101Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.004758Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.004758Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01002Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01506Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02487Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.6668Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.7242Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.8149Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.8486Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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