SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): muscle phenotype

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   muscle phenotype [MP:0005369] <2>(49|57) (54|37|28)
- 1:   abnormal muscle physiology [MP:0002106] <23>(25|33) (27|16|11)
- 1:   abnormal muscle morphology [MP:0002108] <16>(28|31) (31|22|21)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Troponin coil-coiled subunits0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Protein kinase-like (PK-like)0.0000001302Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000006228Direct
EGF/Laminin0.00001593Direct
Nuclear receptor ligand-binding domain0.00009324Direct
p53-like transcription factors0.000111Direct
Growth factor receptor domain0.0001448Direct
Spectrin repeat0.0002431Direct
IP3 receptor type 1 binding core, domain 20.0003873Direct
MIR domain0.0004152Direct
SMAD MH1 domain0.0004152Direct
TB module/8-cys domain0.0004152Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0008495Direct
Riboflavin synthase domain-like0.0008495Direct
Calponin-homology domain, CH-domain0.0008611Direct
alpha-catenin/vinculin-like0.00163Inherited
Notch domain0.001687Inherited
Calcium ATPase, transduction domain A0.002905Inherited
Myosin rod fragments0.003424Inherited
Calcium ATPase, transmembrane domain M0.006055Inherited
SRF-like0.00697Inherited
Flavoproteins0.01381Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.01622Inherited
Homeodomain-like0.01752Inherited
HLH, helix-loop-helix DNA-binding domain0.01986Inherited
Cystine-knot cytokines0.02848Inherited
TIMP-like0.05656Inherited
Spermadhesin, CUB domain0.06668Inherited
Inhibitor of apoptosis (IAP) repeat0.06674Inherited
E set domains0.06846Inherited
Voltage-gated potassium channels0.07447Inherited
Transducin (alpha subunit), insertion domain0.08691Inherited
WW domain0.1094Inherited
Actin-like ATPase domain0.1258Inherited
(Trans)glycosidases0.1428Inherited
Clavaminate synthase-like0.1613Inherited
BPTI-like0.1682Inherited
Nucleotide cyclase0.1821Inherited
Thyroglobulin type-1 domain0.1953Inherited
B-box zinc-binding domain0.2164Inherited
POZ domain0.3148Inherited
Kazal-type serine protease inhibitors0.3222Inherited
Lipocalins0.4356Inherited
Metalloproteases ("zincins"), catalytic domain0.4695Inherited
"Winged helix" DNA-binding domain0.5523Inherited
RING/U-box0.5921Inherited
L domain-like0.8361Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Troponin T0Direct
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Protein kinases, catalytic subunit0.000003024Direct
Spectrin repeat0.00004Direct
EGF-type module0.00004373Direct
Nuclear receptor0.00004666Direct
L domain0.00005984Direct
Meta-cation ATPase, catalytic domain P0.00008332Direct
Nuclear receptor ligand-binding domain0.00009864Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0002561Direct
MIR domain0.0003108Direct
SMAD domain0.0003108Direct
SMAD MH1 domain0.0003108Direct
TB module/8-cys domain0.0003108Direct
Calcium ATPase, transmembrane domain M0.0004423Direct
Calponin-homology domain, CH-domain0.0008606Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0009042Direct
Notch domain0.001241Inherited
NADPH-cytochrome p450 reductase-like0.001241Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001241Inherited
Growth factor receptor domain0.001336Inherited
Calcium ATPase, transduction domain A0.002574Inherited
Myosin rod fragments0.002898Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.004664Inherited
SRF-like0.005281Inherited
Paired domain0.007157Inherited
Homeodomain0.008866Inherited
alpha-catenin/vinculin0.01647Inherited
Forkhead DNA-binding domain0.01837Inherited
Erythroid transcription factor GATA-10.02101Inherited
HLH, helix-loop-helix DNA-binding domain0.02321Inherited
I set domains0.02321Inherited
Laminin-type module0.02341Inherited
Tetramerization domain of potassium channels0.02341Inherited
Inhibitor of apoptosis (IAP) repeat0.03374Inherited
Plakin repeat0.03374Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.04471Inherited
Spermadhesin, CUB domain0.06561Inherited
Voltage-gated potassium channels0.06816Inherited
LIM domain0.06967Inherited
Transducin (alpha subunit), insertion domain0.07873Inherited
ZZ domain0.08577Inherited
Transforming growth factor (TGF)-beta0.09311Inherited
WW domain0.1059Inherited
Small Kunitz-type inhibitors & BPTI-like toxins0.154Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1734Inherited
Thyroglobulin type-1 domain0.1843Inherited
B-box zinc-binding domain0.2118Inherited
EF-hand modules in multidomain proteins0.2514Inherited
Ovomucoid domain III-like0.2868Inherited
Fatty acid binding protein-like0.3602Inherited
28-residue LRR0.4024Inherited
Phosphotyrosine-binding domain (PTB)0.5758Inherited
Ngr ectodomain-like0.9342Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Troponin coil-coiled subunits0Direct
Protein kinase-like (PK-like)0.00000005143Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000002683Direct
EGF/Laminin0.000007091Direct
Nuclear receptor ligand-binding domain0.00004476Direct
p53-like transcription factors0.00005408Direct
Growth factor receptor domain0.00007214Direct
Spectrin repeat0.0001235Direct
IP3 receptor type 1 binding core, domain 20.0002019Direct
SMAD MH1 domain0.0002178Direct
TB module/8-cys domain0.0002178Direct
MIR domain0.0002178Direct
Riboflavin synthase domain-like0.0004598Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0004598Direct
Calponin-homology domain, CH-domain0.0004664Direct
alpha-catenin/vinculin-like0.0009171Direct
Notch domain0.0009512Direct
TSP type-3 repeat0.0009512Direct
Calcium ATPase, transduction domain A0.001683Inherited
Myosin rod fragments0.001999Inherited
Calcium ATPase, transmembrane domain M0.003661Inherited
SRF-like0.004263Inherited
Flavoproteins0.008827Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.01048Inherited
Homeodomain-like0.01141Inherited
dsRNA-binding domain-like0.01251Inherited
HLH, helix-loop-helix DNA-binding domain0.01301Inherited
Cystine-knot cytokines0.01926Inherited
Plakin repeat0.02833Inherited
TIMP-like0.04045Inherited
Spermadhesin, CUB domain0.04849Inherited
Inhibitor of apoptosis (IAP) repeat0.04854Inherited
E set domains0.04997Inherited
Voltage-gated potassium channels0.05475Inherited
Transducin (alpha subunit), insertion domain0.06468Inherited
WW domain0.0835Inherited
Actin-like ATPase domain0.09758Inherited
(Trans)glycosidases0.1124Inherited
Clavaminate synthase-like0.1286Inherited
BPTI-like0.1345Inherited
Nucleotide cyclase0.1471Inherited
Thyroglobulin type-1 domain0.1591Inherited
B-box zinc-binding domain0.1784Inherited
Intermediate filament protein, coiled coil region0.265Inherited
POZ domain0.2707Inherited
Kazal-type serine protease inhibitors0.278Inherited
Lipocalins0.3883Inherited
Metalloproteases ("zincins"), catalytic domain0.4217Inherited
"Winged helix" DNA-binding domain0.5055Inherited
RING/U-box0.5461Inherited
Family A G protein-coupled receptor-like0.725Inherited
L domain-like0.8041Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55486,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    49265,56112
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.000007508Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000007794Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00004025Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00004025Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0000633Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00006416Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001732Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002019Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.0002019Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0009171Direct
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.0009512Direct
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0009512Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009512Direct
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.001881Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003264Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.003661Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.003661Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.003661Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.003661Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.004263Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.007767Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.01048Inherited
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.01353Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01353Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01353Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01466Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.02833Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04915Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.04915Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2905Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3245Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3729Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,49854,57196
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    55486,49854,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    49854,49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00004025Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00004077Direct
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0002019Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002019Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000293Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.0009512Direct
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.0009512Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0009512Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0009512Direct
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0009512Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.001955Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001955Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003661Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003661Inherited
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.004263Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.01048Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01055Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0116Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01353Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01353Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01928Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1052Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)