SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): endocrine/exocrine gland phenotype

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   endocrine/exocrine gland phenotype [MP:0005379] <2>(51|81) (55|36|12)
- 1:   abnormal gland morphology [MP:0002163] <8>(44|71) (50|31|11)
- 1:   abnormal gland physiology [MP:0002164] <4>(9|19) (11|11|5)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nuclear receptor coactivator interlocking domain0Direct
Hedgehog/intein (Hint) domain0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/DD-peptidase0Direct
Homeodomain-like0.00000003136Direct
Nuclear receptor ligand-binding domain0.000003222Direct
Protein kinase-like (PK-like)0.000007706Direct
p53-like transcription factors0.00003824Direct
Insulin-like0.00009983Direct
SMAD MH1 domain0.0003223Direct
"Winged helix" DNA-binding domain0.0007543Direct
SH2 domain0.0009397Direct
E2F-DP heterodimerization region0.001009Inherited
STAT0.001009Inherited
Transcription factor STAT-4 N-domain0.001009Inherited
Bcl-2 inhibitors of programmed cell death0.001542Inherited
HLH, helix-loop-helix DNA-binding domain0.004186Inherited
Tudor/PWWP/MBT0.004189Inherited
Caspase-like0.004202Inherited
PAZ domain0.004228Inherited
Cystine-knot cytokines0.004908Inherited
4-helical cytokines0.006447Inherited
HMG-box0.008798Inherited
Notch domain0.00889Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01047Inherited
The spindle assembly checkpoint protein mad20.02475Inherited
IP3 receptor type 1 binding core, domain 20.02765Inherited
Growth factor receptor domain0.03273Inherited
Nucleic acid-binding proteins0.04839Inherited
TNF receptor-like0.05699Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.09179Inherited
MIR domain0.0946Inherited
Band 7/SPFH domain0.1787Inherited
Cysteine-rich domain0.2053Inherited
E set domains0.2065Inherited
LDL receptor-like module0.2116Inherited
beta-beta-alpha zinc fingers0.2426Inherited
SMAD/FHA domain0.2826Inherited
Thyroglobulin type-1 domain0.2846Inherited
CCCH zinc finger0.2981Inherited
TNF-like0.2992Inherited
BRCT domain0.3393Inherited
EGF/Laminin0.3468Inherited
Rhodanese/Cell cycle control phosphatase0.3852Inherited
Family A G protein-coupled receptor-like0.4148Inherited
WW domain0.4352Inherited
RING/U-box0.462Inherited
Intermediate filament protein, coiled coil region0.8663Inherited
Immunoglobulin0.9443Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Hedgehog (development protein), N-terminal signaling domain0Direct
E2F dimerization segment0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Pointed domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
IP3 receptor type 1 binding core, domain 20Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
p53 DNA-binding domain-like0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
p53 tetramerization domain0Direct
RUNT domain0Direct
Homeodomain0.0000003679Direct
Nuclear receptor ligand-binding domain0.000003528Direct
Nuclear receptor0.00001785Direct
Insulin-like0.00007089Direct
Paired domain0.00007089Direct
Protein kinases, catalytic subunit0.0001056Direct
SMAD domain0.0002309Direct
SMAD MH1 domain0.0002309Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0004081Direct
CUT domain0.0007276Direct
L domain0.0007276Direct
STAT DNA-binding domain0.0007276Direct
STAT0.0007276Direct
Transcription factor STAT-4 N-domain0.0007276Direct
SH2 domain0.001149Inherited
Bcl-2 inhibitors of programmed cell death0.001165Inherited
Caspase catalytic domain0.001349Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001358Inherited
Growth factor receptor domain0.002724Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.003051Inherited
PAZ domain0.003259Inherited
Transforming growth factor (TGF)-beta0.004402Inherited
HLH, helix-loop-helix DNA-binding domain0.004982Inherited
Notch domain0.006743Inherited
Short-chain cytokines0.007024Inherited
HMG-box0.008432Inherited
Tudor domain0.008504Inherited
ets domain0.00859Inherited
Cell cycle transcription factor e2f-dp0.008808Inherited
TNF receptor-like0.01049Inherited
Forkhead DNA-binding domain0.01785Inherited
Extracellular domain of cell surface receptors0.01829Inherited
DNA gyrase/MutL, second domain0.01945Inherited
The spindle assembly checkpoint protein mad20.01945Inherited
DNA gyrase/MutL, N-terminal domain0.01945Inherited
DEATH domain, DD0.02006Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.02091Inherited
DNA polymerase I0.02226Inherited
Ras-binding domain, RBD0.02319Inherited
Cysteine-rich DNA binding domain, (DM domain)0.0477Inherited
Single strand DNA-binding domain, SSB0.0477Inherited
Gonadodropin/Follitropin0.05449Inherited
Transducin (alpha subunit), insertion domain0.06003Inherited
EGF-type module0.06483Inherited
MIR domain0.08236Inherited
Long-chain cytokines0.1061Inherited
Linker histone H1/H50.1249Inherited
DnaQ-like 3'-5' exonuclease0.1351Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1742Inherited
Caspase recruitment domain, CARD0.1773Inherited
Papain-like0.1777Inherited
LDL receptor-like module0.2096Inherited
Thyroglobulin type-1 domain0.2729Inherited
CCCH zinc finger0.2835Inherited
TNF-like0.3015Inherited
V set domains (antibody variable domain-like)0.3105Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.4008Inherited
Cell cycle control phosphatase, catalytic domain0.4294Inherited
WW domain0.4354Inherited
Phosphotyrosine-binding domain (PTB)0.4953Inherited
FHA domain0.5739Inherited
Rhodopsin-like0.6551Inherited
I set domains0.7341Inherited
Cytochrome P4500.7743Inherited
Intermediate filament protein, coiled coil region0.8717Inherited
Pleckstrin-homology domain (PH domain)0.9151Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Hedgehog/intein (Hint) domain0Direct
Hedgehog/DD-peptidase0Direct
Nuclear receptor coactivator interlocking domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Homeodomain-like0.00000001204Direct
Nuclear receptor ligand-binding domain0.000001364Direct
Protein kinase-like (PK-like)0.000003342Direct
p53-like transcription factors0.00001771Direct
Insulin-like0.00004823Direct
SMAD MH1 domain0.000167Direct
"Winged helix" DNA-binding domain0.0004055Direct
SH2 domain0.0005105Direct
STAT0.0005507Direct
E2F-DP heterodimerization region0.0005507Direct
Transcription factor STAT-4 N-domain0.0005507Direct
Bcl-2 inhibitors of programmed cell death0.0008655Direct
HLH, helix-loop-helix DNA-binding domain0.002475Inherited
Tudor/PWWP/MBT0.002478Inherited
Caspase-like0.002484Inherited
PAZ domain0.002502Inherited
Cystine-knot cytokines0.002938Inherited
4-helical cytokines0.003926Inherited
HMG-box0.005439Inherited
Ribonuclease H-like0.005443Inherited
Notch domain0.005506Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006557Inherited
The spindle assembly checkpoint protein mad20.01652Inherited
IP3 receptor type 1 binding core, domain 20.01865Inherited
Growth factor receptor domain0.02239Inherited
Nucleic acid-binding proteins0.03408Inherited
Cysteine-rich DNA binding domain, (DM domain)0.04053Inherited
TNF receptor-like0.04079Inherited
Transducin (alpha subunit), insertion domain0.04907Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.06876Inherited
MIR domain0.07096Inherited
Band 7/SPFH domain0.144Inherited
Cysteine-rich domain0.1681Inherited
E set domains0.1691Inherited
LDL receptor-like module0.1739Inherited
beta-beta-alpha zinc fingers0.2029Inherited
SMAD/FHA domain0.2404Inherited
Thyroglobulin type-1 domain0.2422Inherited
CCCH zinc finger0.2549Inherited
TNF-like0.256Inherited
BRCT domain0.2942Inherited
EGF/Laminin0.3015Inherited
Rhodanese/Cell cycle control phosphatase0.3388Inherited
Family A G protein-coupled receptor-like0.3678Inherited
WW domain0.3879Inherited
RING/U-box0.4143Inherited
Cytochrome P4500.7306Inherited
Intermediate filament protein, coiled coil region0.8365Inherited
Immunoglobulin0.9222Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001812Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00029Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.0003631Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0005507Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005507Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005507Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0005507Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0005507Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0005507Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.001762Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.002502Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.003555Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.005506Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01652Inherited
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.01865Inherited
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.01865Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01876Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03309Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.03309Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03316Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.04293Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.04413Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.04758Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.05813Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.09105Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.09105Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1631Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2942Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3472Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6535Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9009Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005507Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0005507Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005507Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.005259Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01707Inherited
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.01865Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02094Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0711Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1065Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)