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Mammalian Phenotype (MP): reproductive system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   reproductive system phenotype [MP:0005389] <2>(38|58) (47|18|6)
- 1:   abnormal reproductive system morphology [MP:0002160] <12>(28|46) (37|15|6)
- 1:   abnormal reproductive system physiology [MP:0001919] <10>(21|39) (27|11|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor ligand-binding domain0.000000168Direct
Cystine-knot cytokines0.000000175Direct
Tudor/PWWP/MBT0.00008696Direct
SMAD MH1 domain0.0001334Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002485Direct
Protein kinase-like (PK-like)0.005702Inherited
E2F-DP heterodimerization region0.006288Inherited
Cysteine-rich DNA binding domain, (DM domain)0.006288Inherited
4-helical cytokines0.01051Inherited
PAZ domain0.01515Inherited
HMA, heavy metal-associated domain0.01696Inherited
The spindle assembly checkpoint protein mad20.01696Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.01883Inherited
Bcl-2 inhibitors of programmed cell death0.02888Inherited
Flavoproteins0.03743Inherited
STAT0.03743Inherited
Transcription factor STAT-4 N-domain0.03743Inherited
Homeodomain-like0.04179Inherited
LDL receptor-like module0.1197Inherited
Alpha-macroglobulin receptor domain0.1342Inherited
PYP-like sensor domain (PAS domain)0.192Inherited
Nucleic acid-binding proteins0.2032Inherited
Blood coagulation inhibitor (disintegrin)0.2217Inherited
Metalloproteases ("zincins"), catalytic domain0.2448Inherited
SMAD/FHA domain0.2514Inherited
EGF/Laminin0.2571Inherited
SAICAR synthase-like0.2704Inherited
Alkaline phosphatase-like0.2854Inherited
Terpenoid cyclases/Protein prenyltransferases0.2995Inherited
HMG-box0.3618Inherited
Fibronectin type III0.5305Inherited
Ribosomal protein S5 domain 2-like0.5562Inherited
L domain-like0.663Inherited
BAR/IMD domain-like0.6799Inherited
Immunoglobulin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
p53 DNA-binding domain-like0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 tetramerization domain0Direct
Nuclear receptor ligand-binding domain0.0000001278Direct
Nuclear receptor0.0000009119Direct
Transforming growth factor (TGF)-beta0.000003372Direct
Tudor domain0.00001392Direct
SMAD domain0.00008291Direct
SMAD MH1 domain0.00008291Direct
E2F dimerization segment0.001079Inherited
Short-chain cytokines0.002726Inherited
DNA repair protein MutS, domain III0.003748Inherited
Gonadodropin/Follitropin0.003748Inherited
NADPH-cytochrome p450 reductase-like0.003748Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.003748Inherited
Insulin-like0.0041Inherited
Linker histone H1/H50.0041Inherited
Cysteine-rich DNA binding domain, (DM domain)0.004444Inherited
L domain0.004444Inherited
Extracellular domain of cell surface receptors0.008975Inherited
Protein kinases, catalytic subunit0.009523Inherited
PAZ domain0.0112Inherited
DNA gyrase/MutL, second domain0.01231Inherited
gamma-adaptin C-terminal appendage domain-like0.01231Inherited
HMA, heavy metal-associated domain0.01231Inherited
The spindle assembly checkpoint protein mad20.01231Inherited
Neurotrophin0.01231Inherited
DNA gyrase/MutL, N-terminal domain0.01231Inherited
PHD domain0.01248Inherited
Bcl-2 inhibitors of programmed cell death0.02206Inherited
Cell cycle transcription factor e2f-dp0.02206Inherited
Single strand DNA-binding domain, SSB0.02871Inherited
STAT DNA-binding domain0.02871Inherited
STAT0.02871Inherited
Transcription factor STAT-4 N-domain0.02871Inherited
Nuclear receptor coactivator interlocking domain0.03582Inherited
Long-chain cytokines0.05993Inherited
Homeodomain0.06562Inherited
Astacin0.0704Inherited
Histone lysine methyltransferases0.0741Inherited
LDL receptor-like module0.1051Inherited
Complement components0.1133Inherited
Alpha-macroglobulin receptor domain0.1133Inherited
Forkhead DNA-binding domain0.1633Inherited
Growth factor receptor domain0.1781Inherited
Reprolysin-like0.199Inherited
EGF-type module0.1995Inherited
Blood coagulation inhibitor (disintegrin)0.1996Inherited
ABC transporter ATPase domain-like0.2836Inherited
HMG-box0.344Inherited
Fibronectin type III0.5357Inherited
Ngr ectodomain-like0.6235Inherited
I set domains0.8977Inherited
Rhodopsin-like0.9856Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Nuclear receptor ligand-binding domain0.00000006672Direct
Cystine-knot cytokines0.00000006966Direct
Tudor/PWWP/MBT0.0000417Direct
SMAD MH1 domain0.0000661Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0001266Direct
DNA repair protein MutS, domain III0.003261Inherited
Protein kinase-like (PK-like)0.003434Inherited
Insulin-like0.003489Inherited
Cysteine-rich DNA binding domain, (DM domain)0.00382Inherited
E2F-DP heterodimerization region0.00382Inherited
4-helical cytokines0.006584Inherited
PAZ domain0.009729Inherited
HMA, heavy metal-associated domain0.01101Inherited
The spindle assembly checkpoint protein mad20.01101Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.01229Inherited
Bcl-2 inhibitors of programmed cell death0.01955Inherited
Flavoproteins0.02585Inherited
STAT0.02585Inherited
Transcription factor STAT-4 N-domain0.02585Inherited
Homeodomain-like0.02913Inherited
Nuclear receptor coactivator interlocking domain0.03267Inherited
"Winged helix" DNA-binding domain0.04214Inherited
LDL receptor-like module0.09227Inherited
Alpha-macroglobulin receptor domain0.1049Inherited
Growth factor receptor domain0.1418Inherited
PYP-like sensor domain (PAS domain)0.1561Inherited
Nucleic acid-binding proteins0.1662Inherited
Blood coagulation inhibitor (disintegrin)0.1834Inherited
Metalloproteases ("zincins"), catalytic domain0.205Inherited
SMAD/FHA domain0.2111Inherited
EGF/Laminin0.2163Inherited
SAICAR synthase-like0.2289Inherited
Ribonuclease H-like0.2297Inherited
Alkaline phosphatase-like0.243Inherited
dsRNA-binding domain-like0.243Inherited
Terpenoid cyclases/Protein prenyltransferases0.2563Inherited
HMG-box0.3161Inherited
Cytochrome P4500.4422Inherited
Fibronectin type III0.4834Inherited
Ribosomal protein S5 domain 2-like0.5095Inherited
L domain-like0.6204Inherited
BAR/IMD domain-like0.638Inherited
Family A G protein-coupled receptor-like0.9617Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001331Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003261Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00382Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.00382Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00382Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02585Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02585Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02585Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.03267Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.03267Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05261Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.1514Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.1834Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3287Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4653Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9393Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00382Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02585Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02585Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1706Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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