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Mammalian Phenotype (MP): abnormal mononuclear cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
0:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|57) (41|28|14)
- 1:   abnormal lymphocyte morphology [MP:0002619] <5>(27|46) (33|26|14)
- 1:   abnormal mononuclear phagocyte morphology [MP:0008248] <3>(6|14) (8|5|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000000009069Direct
p53-like transcription factors0.00002833Direct
MHC antigen-recognition domain0.000619Direct
DNA polymerase beta, N-terminal domain-like0.003386Inherited
Flavoproteins0.003662Inherited
BRCT domain0.00449Inherited
Triple coiled coil domain of C-type lectins0.01187Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01262Inherited
Bcl-2 inhibitors of programmed cell death0.01788Inherited
E2F-DP heterodimerization region0.02507Inherited
SH2 domain0.02722Inherited
WWE domain0.1018Inherited
SMAD/FHA domain0.1538Inherited
SH3-domain0.1668Inherited
DNA/RNA polymerases0.1676Inherited
Nuclear receptor ligand-binding domain0.1911Inherited
Cysteine-rich domain0.2278Inherited
Nucleotidyltransferase0.246Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2877Inherited
Riboflavin synthase domain-like0.2877Inherited
DEATH domain0.3454Inherited
Calponin-homology domain, CH-domain0.4624Inherited
Integrin alpha N-terminal domain0.4632Inherited
Ran binding protein zinc finger-like0.5053Inherited
Integrin domains0.646Inherited
DBL homology domain (DH-domain)0.646Inherited
Toll/Interleukin receptor TIR domain0.7193Inherited
SET domain0.9598Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
BAFF receptor-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT DNA-binding domain0Direct
STAT0Direct
DNA polymerase beta-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Interleukin 17F, IL-17F0Direct
Transcription factor STAT-4 N-domain0Direct
DNA polymerase beta-like, second domain0Direct
RUNT domain0Direct
TNF receptor-like0.000000008115Direct
C1 set domains (antibody constant domain-like)0.0000002284Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00005258Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000407Direct
MHC antigen-recognition domain0.0004163Direct
DEATH domain, DD0.0006098Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001209Inherited
DNA polymerase beta, N-terminal domain-like0.002266Inherited
Pointed domain0.002494Inherited
E2F dimerization segment0.008264Inherited
Cytochrome p450 reductase N-terminal domain-like0.008447Inherited
Triple coiled coil domain of C-type lectins0.008447Inherited
beta-glycanases0.008447Inherited
C2 set domains0.01333Inherited
Bcl-2 inhibitors of programmed cell death0.01333Inherited
Interferon regulatory factor0.01333Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.01884Inherited
SH2 domain0.02056Inherited
Tetraspanin0.02521Inherited
NADPH-cytochrome p450 reductase-like0.02521Inherited
Nuclear receptor coactivator interlocking domain0.02521Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02521Inherited
Pleckstrin-homology domain (PH domain)0.02712Inherited
Myb/SANT domain0.03404Inherited
Long-chain cytokines0.03617Inherited
DNA polymerase I0.05077Inherited
WWE domain0.05077Inherited
Cell cycle transcription factor e2f-dp0.0554Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.08352Inherited
MATH domain0.1114Inherited
SH3-domain0.1425Inherited
Nuclear receptor ligand-binding domain0.1632Inherited
Nuclear receptor0.1632Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2904Inherited
PLC-like (P variant)0.2904Inherited
Caspase recruitment domain, CARD0.3034Inherited
ets domain0.3201Inherited
FHA domain0.332Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.3874Inherited
V set domains (antibody variable domain-like)0.4228Inherited
Calponin-homology domain, CH-domain0.4431Inherited
Ran binding protein zinc finger-like0.4699Inherited
Integrin domains0.6147Inherited
DBL homology domain (DH-domain)0.6147Inherited
CCCH zinc finger0.6267Inherited
Toll/Interleukin receptor TIR domain0.7294Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000000003358Direct
p53-like transcription factors0.00001301Direct
MHC antigen-recognition domain0.000329Direct
DNA polymerase beta, N-terminal domain-like0.001976Inherited
Flavoproteins0.00215Inherited
BRCT domain0.002661Inherited
TNF-like0.002995Inherited
Triple coiled coil domain of C-type lectins0.007513Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008016Inherited
Bcl-2 inhibitors of programmed cell death0.01165Inherited
E2F-DP heterodimerization region0.01675Inherited
SH2 domain0.01832Inherited
Nuclear receptor coactivator interlocking domain0.02296Inherited
beta-beta-alpha zinc fingers0.05597Inherited
WWE domain0.07704Inherited
SMAD/FHA domain0.1221Inherited
SH3-domain0.1333Inherited
DNA/RNA polymerases0.134Inherited
Nuclear receptor ligand-binding domain0.1553Inherited
Protein kinase-like (PK-like)0.1765Inherited
Cysteine-rich domain0.1891Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1903Inherited
Nucleotidyltransferase0.2061Inherited
Riboflavin synthase domain-like0.2452Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2452Inherited
DEATH domain0.3001Inherited
Calponin-homology domain, CH-domain0.4147Inherited
Integrin alpha N-terminal domain0.4155Inherited
Ran binding protein zinc finger-like0.4577Inherited
Immunoglobulin0.5301Inherited
DBL homology domain (DH-domain)0.6024Inherited
Integrin domains0.6024Inherited
CCCH zinc finger0.616Inherited
Acyl-CoA N-acyltransferases (Nat)0.6368Inherited
Toll/Interleukin receptor TIR domain0.6795Inherited
SET domain0.9396Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00000005257Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000007378Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00002966Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00004128Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0004995Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0004995Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0006064Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.001806Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.007513Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.007513Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01675Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01675Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.05034Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1135Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1188Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1404Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2087Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4577Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.4577Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.6024Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.6797Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000006363Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0009972Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.007513Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01675Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4577Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.6797Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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