SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal intercellular signaling peptide or protein level

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ 1:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
0:   abnormal intercellular signaling peptide or protein level [MP:0008835] <3>(12|19) (12|9|3)
- 1:   abnormal cytokine level [MP:0008713] <5>(11|18) (11|7|2)
- 1:   abnormal transforming growth factor beta level [MP:0008836] <2>(0|0) (0|0|0)
- 1:   abnormal bradykinin level [MP:0009812](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
STAT0.00000006394Direct
Transcription factor STAT-4 N-domain0.00000006394Direct
p53-like transcription factors0.00000137Direct
DEATH domain0.000005736Direct
SH2 domain0.00004619Direct
Triple coiled coil domain of C-type lectins0.0002002Direct
4-helical cytokines0.000279Direct
Fibronectin type III0.0004879Direct
Toll/Interleukin receptor TIR domain0.0006983Direct
Immunoglobulin0.0009791Direct
CCCH zinc finger0.01926Inherited
Caspase-like0.1119Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0.00000004705Direct
Transcription factor STAT-4 N-domain0.00000004705Direct
STAT0.00000004705Direct
Pyrin domain, PYD0.00000425Direct
Interleukin-1 (IL-1)0.00001062Direct
Interferon regulatory factor0.0000365Direct
SH2 domain0.00004025Direct
Triple coiled coil domain of C-type lectins0.0001363Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0001424Direct
TNF receptor-like0.0001619Direct
Fibronectin type III0.0004712Direct
Interferons/interleukin-10 (IL-10)0.000597Direct
Long-chain cytokines0.0006325Direct
Toll/Interleukin receptor TIR domain0.001068Inherited
Caspase recruitment domain, CARD0.008124Inherited
DEATH domain, DD0.009573Inherited
28-residue LRR0.01513Inherited
CCCH zinc finger0.01589Inherited
Caspase catalytic domain0.09669Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0.00000002494Direct
Transcription factor STAT-4 N-domain0.00000002494Direct
p53-like transcription factors0.0000005621Direct
DEATH domain0.000002472Direct
SH2 domain0.00002164Direct
Triple coiled coil domain of C-type lectins0.0001013Direct
4-helical cytokines0.0001431Direct
Fibronectin type III0.0002573Direct
Toll/Interleukin receptor TIR domain0.0003735Direct
Immunoglobulin0.0005338Direct
CCCH zinc finger0.0126Inherited
Caspase-like0.0857Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00000002494Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000002494Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000002494Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.0001013Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0001753Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002261Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0004897Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0857Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000002494Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000002494Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)