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Mammalian Phenotype (MP): integument phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   integument phenotype [MP:0010771] <5>(46|64) (53|34|18)
- 1:   abnormal skin morphology [MP:0002060] <16>(19|26) (24|13|8)
- 1:   abnormal skin adnexa morphology [MP:0010678] <12>(21|28) (23|21|10)
- 1:   abnormal skin physiology [MP:0005501] <12>(6|10) (7|1|0)
- 1:   abnormal touch/ nociception [MP:0001968] <7>(9|9) (9|5|0)
- 1:   abnormal skin adnexa physiology [MP:0010680] <6>(5|8) (6|7|4)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Lamin A/C globular tail domain0Direct
p53 tetramerization domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
p53-like transcription factors0.000001235Direct
Intermediate filament protein, coiled coil region0.000007105Direct
EGF/Laminin0.0001013Direct
Protein kinase-like (PK-like)0.0002534Direct
Integrin beta tail domain0.0003631Direct
Cytokine0.001135Inherited
Growth factor receptor domain0.001319Inherited
Nuclear receptor coactivator interlocking domain0.004511Inherited
Notch domain0.004511Inherited
ACT-like0.004511Inherited
STAT0.005105Inherited
Transcription factor STAT-4 N-domain0.005105Inherited
4-helical cytokines0.006785Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.008663Inherited
Nuclear receptor ligand-binding domain0.01232Inherited
Lipoxigenase0.01491Inherited
FnI-like domain0.01536Inherited
Band 7/SPFH domain0.03194Inherited
Periplasmic binding protein-like I0.03708Inherited
HLH, helix-loop-helix DNA-binding domain0.03925Inherited
DNA repair protein MutS, domain III0.0408Inherited
Homeodomain-like0.04678Inherited
Family A G protein-coupled receptor-like0.05249Inherited
CalX-like0.05589Inherited
SMAD MH1 domain0.05589Inherited
Transducin (alpha subunit), insertion domain0.08228Inherited
Leucine zipper domain0.1076Inherited
TNF receptor-like0.1207Inherited
Cadherin-like0.1316Inherited
Periplasmic binding protein-like II0.1453Inherited
Integrin domains0.154Inherited
PAZ domain0.1689Inherited
Frizzled cysteine-rich domain0.1932Inherited
L domain-like0.216Inherited
Fibronectin type III0.2405Inherited
Cyclin-like0.2939Inherited
Nicotinic receptor ligand binding domain-like0.3452Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3452Inherited
vWA-like0.3619Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6072Inherited
Voltage-gated potassium channels0.6884Inherited
C-type lectin-like0.999Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Phenylalanine metabolism regulatory domain0Direct
Lamin A/C globular tail domain0Direct
p53 DNA-binding domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 tetramerization domain0Direct
RUNT domain0Direct
Intermediate filament protein, coiled coil region0.000006384Direct
Integrin beta tail domain0.0002479Direct
EGF-type module0.000464Direct
Growth factor receptor domain0.0005417Direct
Protein kinases, catalytic subunit0.0008342Direct
E2F dimerization segment0.0009086Direct
Plakin repeat0.0009086Direct
Integrin beta EGF-like domains0.001185Inherited
VWC domain0.002173Inherited
Notch domain0.003253Inherited
Interleukin-1 (IL-1)0.003253Inherited
Nuclear receptor coactivator interlocking domain0.003253Inherited
L domain0.003796Inherited
STAT DNA-binding domain0.003796Inherited
STAT0.003796Inherited
Transcription factor STAT-4 N-domain0.003796Inherited
Nuclear receptor0.007042Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01029Inherited
Nuclear receptor ligand-binding domain0.01133Inherited
Lipoxigenase N-terminal domain0.01143Inherited
Animal lipoxigenases0.01143Inherited
Fibroblast growth factors (FGF)0.01318Inherited
DNA repair protein MutS, domain III0.03244Inherited
Short-chain cytokines0.03608Inherited
Papain-like0.03608Inherited
TNF receptor-like0.03688Inherited
HLH, helix-loop-helix DNA-binding domain0.04073Inherited
SMAD domain0.04619Inherited
SMAD MH1 domain0.04619Inherited
CalX-beta domain0.04619Inherited
Rhodopsin-like0.04702Inherited
Ankyrin repeat0.04707Inherited
Long-chain cytokines0.05223Inherited
Laminin-type module0.06788Inherited
Transducin (alpha subunit), insertion domain0.07177Inherited
Phosphate binding protein-like0.08722Inherited
Cadherin0.09338Inherited
Integrin A (or I) domain0.104Inherited
Leucine zipper domain0.1041Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.1042Inherited
L-arabinose binding protein-like0.1086Inherited
Homeodomain0.1234Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.131Inherited
Integrin domains0.1432Inherited
PAZ domain0.1498Inherited
Frizzled cysteine-rich domain0.179Inherited
Paired domain0.2007Inherited
RING finger domain, C3HC40.2011Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.2537Inherited
Fibronectin type III0.2638Inherited
Ngr ectodomain-like0.2724Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3405Inherited
Nicotinic receptor ligand binding domain-like0.3405Inherited
FHA domain0.4043Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4432Inherited
C-type lectin domain0.9571Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
p53 tetramerization domain0Direct
Di-copper centre-containing domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
p53-like transcription factors0.0000005059Direct
Intermediate filament protein, coiled coil region0.000003066Direct
EGF/Laminin0.00004895Direct
Protein kinase-like (PK-like)0.0001293Direct
Integrin beta tail domain0.0001889Direct
Cytokine0.0006244Direct
Plakin repeat0.0007243Direct
Growth factor receptor domain0.0007329Direct
Galactose oxidase, central domain0.002676Inherited
Notch domain0.002676Inherited
Nuclear receptor coactivator interlocking domain0.002676Inherited
ACT-like0.002676Inherited
STAT0.003058Inherited
Transcription factor STAT-4 N-domain0.003058Inherited
4-helical cytokines0.004147Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.005356Inherited
Nuclear receptor ligand-binding domain0.007819Inherited
Lipoxigenase0.009564Inherited
FnI-like domain0.009879Inherited
Band 7/SPFH domain0.02184Inherited
Periplasmic binding protein-like I0.02558Inherited
HLH, helix-loop-helix DNA-binding domain0.02717Inherited
DNA repair protein MutS, domain III0.02837Inherited
Homeodomain-like0.03293Inherited
Ankyrin repeat0.03427Inherited
Family A G protein-coupled receptor-like0.03721Inherited
SH2 domain0.03854Inherited
CalX-like0.03988Inherited
SMAD MH1 domain0.03988Inherited
Transducin (alpha subunit), insertion domain0.0609Inherited
DNA/RNA polymerases0.06374Inherited
Leucine zipper domain0.08192Inherited
TNF receptor-like0.09312Inherited
Cadherin-like0.1025Inherited
Periplasmic binding protein-like II0.1145Inherited
Integrin domains0.1223Inherited
PAZ domain0.1351Inherited
Frizzled cysteine-rich domain0.1571Inherited
L domain-like0.1781Inherited
Fibronectin type III0.2009Inherited
Cyclin-like0.251Inherited
Nicotinic receptor ligand binding domain-like0.2999Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2999Inherited
vWA-like0.3162Inherited
Cysteine-rich domain0.5025Inherited
WD40 repeat-like0.5526Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5619Inherited
Voltage-gated potassium channels0.6469Inherited
C-type lectin-like0.9858Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.000004788Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0001889Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0007243Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0.002676Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002771Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003058Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.003058Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.003058Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.003058Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.003058Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.003058Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.003279Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004631Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.009354Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.009478Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.009478Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.009564Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01432Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.01747Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02837Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.03988Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.04243Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04412Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.0635Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06367Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06367Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.06374Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.09305Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2999Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0001889Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000238Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0002721Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.003058Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003058Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.003058Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.005716Inherited
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.009478Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.009564Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01702Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.02184Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.03011Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03988Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.04364Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.05899Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.09305Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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