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Mammalian Phenotype (MP): abnormal hematopoietic cell number
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
Proteasome subunits | 0 | DIRECT |
RUNT domain | 0 | DIRECT |
DNA polymerase beta-like | 0 | DIRECT |
BAFF receptor-like | 0 | DIRECT |
C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
Interleukin 17F, IL-17F | 0 | DIRECT |
DNA polymerase beta-like, second domain | 0 | DIRECT |
Short-chain cytokines | 0.0000001159 | DIRECT |
Rel/Dorsal transcription factors, DNA-binding domain | 0.0001729 | DIRECT |
Pyrin domain, PYD | 0.0003721 | DIRECT |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001317 | INHERITED FROM: abnormal lymphocyte cell number || decreased lymphocyte cell number || abnormal B cell number || decreased CD8-positive, alpha-beta T cell number || abnormal macrophage cell number || decreased dendritic cell number || abnormal dendritic cell number || decreased hematopoietic cell number || decreased leukocyte cell number || abnormal leukocyte cell number || increased hematopoietic cell number || abnormal T cell number || decreased CD4-positive, alpha beta T cell number || decreased T cell number || increased leukocyte cell number |
ets domain | 0.003364 | INHERITED FROM: decreased thymocyte number |
Notch domain | 0.004272 | INHERITED FROM: increased hematopoietic cell number |
Interleukin-1 (IL-1) | 0.004272 | INHERITED FROM: abnormal neutrophil cell number || increased neutrophil cell number || increased granulocyte number |
DNA polymerase beta, N-terminal domain-like | 0.004272 | INHERITED FROM: abnormal lymphocyte cell number || decreased lymphocyte cell number || decreased leukocyte cell number |
Pointed domain | 0.005157 | INHERITED FROM: decreased thymocyte number || abnormal lymphocyte cell number || decreased lymphocyte cell number || thrombocytopenia || decreased leukocyte cell number |
Erythroid transcription factor GATA-1 | 0.01288 | INHERITED FROM: decreased erythrocyte cell number |
AraD-like aldolase/epimerase | 0.01362 | INHERITED FROM: abnormal myeloid cell number || abnormal reticulocyte cell number || increased myeloid cell number || reticulocytosis |
Tissue inhibitor of metalloproteinases, TIMP | 0.01362 | INHERITED FROM: abnormal granulocyte number || abnormal neutrophil cell number || increased neutrophil cell number || increased granulocyte number |
Triple coiled coil domain of C-type lectins | 0.01362 | INHERITED FROM: abnormal monocyte cell number |
Cytochrome p450 reductase N-terminal domain-like | 0.01362 | INHERITED FROM: increased macrophage cell number || abnormal macrophage cell number || increased osteoclast cell number |
WWE domain | 0.01464 | INHERITED FROM: decreased marginal zone B cell number || abnormal mature B cell number || decreased mature B cell number |
E2F dimerization segment | 0.01464 | INHERITED FROM: decreased double-positive T cell number || abnormal T cell number |
Ran binding protein zinc finger-like | 0.01747 | INHERITED FROM: abnormal B cell number || decreased B cell number || decreased B-1a cell number |
Toll/Interleukin receptor TIR domain | 0.02031 | INHERITED FROM: increased mature B cell number || decreased mature B cell number |
Bcl-2 inhibitors of programmed cell death | 0.02513 | INHERITED FROM: abnormal mature B cell number || abnormal immature B cell number || decreased mature B cell number || abnormal T cell number || increased pre-B cell number |
Interferon regulatory factor | 0.02513 | INHERITED FROM: decreased plasmacytoid dendritic cell number || increased lymphocyte cell number || decreased dendritic cell number || abnormal mature B cell number || decreased mature B cell number || abnormal T cell number || abnormal plasmacytoid dendritic cell number || decreased T cell number |
SH2 domain | 0.02539 | INHERITED FROM: decreased single-positive T cell number || decreased thymocyte number || decreased immature B cell number || increased lymphocyte cell number || abnormal immature B cell number |
NADPH-cytochrome p450 reductase-like | 0.03943 | INHERITED FROM: increased macrophage cell number || abnormal macrophage cell number || increased osteoclast cell number |
NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.03943 | INHERITED FROM: increased macrophage cell number || abnormal macrophage cell number || increased osteoclast cell number |
Nuclear receptor coactivator interlocking domain | 0.03943 | INHERITED FROM: increased T cell number |
V set domains (antibody variable domain-like) | 0.07302 | INHERITED FROM: abnormal T-helper 17 cell number |
Cell cycle transcription factor e2f-dp | 0.0894 | INHERITED FROM: decreased double-positive T cell number |
TNF receptor-like | 0.09235 | INHERITED FROM: abnormal lymphocyte cell number || increased CD4-positive, alpha beta T cell number || increased hematopoietic cell number || increased leukocyte cell number |
DEATH domain, DD | 0.09235 | INHERITED FROM: abnormal lymphocyte cell number || increased transitional stage B cell number |
Interferon regulatory factor 3 (IRF3), transactivation domain | 0.1227 | INHERITED FROM: decreased plasmacytoid dendritic cell number || increased B cell number || decreased dendritic cell number || absent lymphocyte || abnormal dendritic cell number || absent B cells || decreased mature B cell number || abnormal plasmacytoid dendritic cell number |
MATH domain | 0.1697 | INHERITED FROM: abnormal immature B cell number |
C1 set domains (antibody constant domain-like) | 0.1888 | INHERITED FROM: abnormal leukocyte cell number || absent CD8-positive, alpha-beta T cells |
Integrin domains | 0.2165 | INHERITED FROM: abnormal eosinophil cell number || decreased CD4-positive, alpha beta T cell number || decreased T cell number |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.2182 | INHERITED FROM: abnormal CD4-positive, alpha beta T cell number || abnormal lymphocyte cell number || decreased lymphocyte cell number || abnormal neutrophil cell number || abnormal CD8-positive, alpha-beta T cell number || decreased hematopoietic cell number || decreased leukocyte cell number || abnormal T cell number |
MHC antigen-recognition domain | 0.2821 | INHERITED FROM: abnormal T cell number || absent CD8-positive, alpha-beta T cells |
CCCH zinc finger | 0.364 | INHERITED FROM: increased mature B cell number |
Calponin-homology domain, CH-domain | 0.3801 | INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number |
Phoshoinositide 3-kinase (PI3K) helical domain | 0.4316 | INHERITED FROM: abnormal CD4-positive, alpha beta T cell number || abnormal alpha-beta T cell number || abnormal neutrophil cell number || increased neutrophil cell number || abnormal CD8-positive, alpha-beta T cell number || increased granulocyte number |
DBL homology domain (DH-domain) | 0.4326 | INHERITED FROM: increased transitional stage T1 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4774 | INHERITED FROM: decreased thymocyte number |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.4874 | INHERITED FROM: increased mature B cell number || abnormal immature B cell number |
Noncollagenous (NC1) domain of collagen IV | 0.5118 | INHERITED FROM: decreased erythrocyte cell number || decreased myeloid cell number |
Pleckstrin-homology domain (PH domain) | 0.5294 | INHERITED FROM: decreased transitional stage B cell number |
SH3-domain | 0.5439 | INHERITED FROM: decreased single-positive T cell number |
A DNA-binding domain in eukaryotic transcription factors | 0.5855 | INHERITED FROM: thrombocytopenia |
Cyclin | 0.5855 | INHERITED FROM: decreased hematopoietic stem cell number || decreased erythrocyte cell number |
Nuclear receptor ligand-binding domain | 0.5969 | INHERITED FROM: abnormal macrophage cell number |
Nuclear receptor | 0.5969 | INHERITED FROM: abnormal macrophage cell number |
PLC-like (P variant) | 0.7528 | INHERITED FROM: decreased B-2 B cell number |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.9293 | INHERITED FROM: abnormal reticulocyte cell number || increased myeloid cell number || reticulocytosis |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
Proteasome subunits | 0 | Direct |
RUNT domain | 0 | Direct |
DNA polymerase beta-like | 0 | Direct |
BAFF receptor-like | 0 | Direct |
C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
Interleukin 17F, IL-17F | 0 | Direct |
DNA polymerase beta-like, second domain | 0 | Direct |
Short-chain cytokines | 0.0000001159 | Direct |
Rel/Dorsal transcription factors, DNA-binding domain | 0.0001729 | Direct |
Pyrin domain, PYD | 0.0003721 | Direct |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001317 | Inherited |
ets domain | 0.003364 | Inherited |
Notch domain | 0.004272 | Inherited |
Interleukin-1 (IL-1) | 0.004272 | Inherited |
DNA polymerase beta, N-terminal domain-like | 0.004272 | Inherited |
Pointed domain | 0.005157 | Inherited |
Erythroid transcription factor GATA-1 | 0.01288 | Inherited |
AraD-like aldolase/epimerase | 0.01362 | Inherited |
Tissue inhibitor of metalloproteinases, TIMP | 0.01362 | Inherited |
Triple coiled coil domain of C-type lectins | 0.01362 | Inherited |
Cytochrome p450 reductase N-terminal domain-like | 0.01362 | Inherited |
WWE domain | 0.01464 | Inherited |
E2F dimerization segment | 0.01464 | Inherited |
Ran binding protein zinc finger-like | 0.01747 | Inherited |
Toll/Interleukin receptor TIR domain | 0.02031 | Inherited |
Bcl-2 inhibitors of programmed cell death | 0.02513 | Inherited |
Interferon regulatory factor | 0.02513 | Inherited |
SH2 domain | 0.02539 | Inherited |
NADPH-cytochrome p450 reductase-like | 0.03943 | Inherited |
NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.03943 | Inherited |
Nuclear receptor coactivator interlocking domain | 0.03943 | Inherited |
V set domains (antibody variable domain-like) | 0.07302 | Inherited |
Cell cycle transcription factor e2f-dp | 0.0894 | Inherited |
TNF receptor-like | 0.09235 | Inherited |
DEATH domain, DD | 0.09235 | Inherited |
Interferon regulatory factor 3 (IRF3), transactivation domain | 0.1227 | Inherited |
MATH domain | 0.1697 | Inherited |
C1 set domains (antibody constant domain-like) | 0.1888 | Inherited |
Integrin domains | 0.2165 | Inherited |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.2182 | Inherited |
MHC antigen-recognition domain | 0.2821 | Inherited |
CCCH zinc finger | 0.364 | Inherited |
Calponin-homology domain, CH-domain | 0.3801 | Inherited |
Phoshoinositide 3-kinase (PI3K) helical domain | 0.4316 | Inherited |
DBL homology domain (DH-domain) | 0.4326 | Inherited |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4774 | Inherited |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.4874 | Inherited |
Noncollagenous (NC1) domain of collagen IV | 0.5118 | Inherited |
Pleckstrin-homology domain (PH domain) | 0.5294 | Inherited |
SH3-domain | 0.5439 | Inherited |
A DNA-binding domain in eukaryotic transcription factors | 0.5855 | Inherited |
Cyclin | 0.5855 | Inherited |
Nuclear receptor ligand-binding domain | 0.5969 | Inherited |
Nuclear receptor | 0.5969 | Inherited |
PLC-like (P variant) | 0.7528 | Inherited |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.9293 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57424,50494 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases | 0 | DIRECT |
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like | 0 | DIRECT |
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | DIRECT |
49562,51045 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 51045 - WW domain | 0 | DIRECT |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | DIRECT |
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0.000139 | DIRECT |
47986,47986 47986 - DEATH domain 47986 - DEATH domain | 0.00109 | INHERITED FROM: abnormal leukocyte cell number || abnormal CD4-positive, alpha beta T cell number || increased hematopoietic cell number || abnormal lymphocyte cell number || increased leukocyte cell number |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.001455 | INHERITED FROM: decreased leukocyte cell number || decreased T cell number || abnormal T cell number || abnormal leukocyte cell number || decreased hematopoietic cell number || abnormal lymphocyte cell number || decreased lymphocyte cell number |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0.004155 | INHERITED FROM: decreased follicular B cell number || abnormal mature B cell number || decreased double-negative T cell number || decreased immature B cell number || abnormal immature B cell number || abnormal CD4-positive, alpha beta T cell number || decreased single-positive T cell number || decreased transitional stage B cell number || increased transitional stage B cell number || increased hematopoietic cell number || decreased mature B cell number || abnormal lymphocyte cell number || increased immature B cell number || increased leukocyte cell number || increased lymphocyte cell number |
57944,56436 57944 - Triple coiled coil domain of C-type lectins 56436 - C-type lectin-like | 0.01215 | INHERITED FROM: abnormal monocyte cell number |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0.02898 | INHERITED FROM: decreased double-positive T cell number |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0.08899 | INHERITED FROM: decreased immature B cell number || abnormal immature B cell number || decreased single-positive T cell number |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.1193 | INHERITED FROM: decreased leukocyte cell number |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1319 | INHERITED FROM: absent mast cells |
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like | 0.1498 | INHERITED FROM: increased hematopoietic cell number || abnormal lymphocyte cell number || abnormal neutrophil cell number || increased leukocyte cell number |
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like | 0.1634 | INHERITED FROM: abnormal immature B cell number |
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.1781 | INHERITED FROM: decreased T cell number |
69179,69179 69179 - Integrin domains 69179 - Integrin domains | 0.1781 | INHERITED FROM: decreased T cell number |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.2098 | INHERITED FROM: abnormal macrophage cell number |
47454,57959 47454 - A DNA-binding domain in eukaryotic transcription factors 57959 - Leucine zipper domain | 0.2995 | INHERITED FROM: thrombocytopenia |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0.3132 | INHERITED FROM: abnormal T cell number || abnormal leukocyte cell number || absent CD8-positive, alpha-beta T cells |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.4232 | INHERITED FROM: decreased transitional stage T2 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number |
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain | 0.4235 | INHERITED FROM: increased CD8-positive, alpha-beta T cell number || increased alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0.4235 | INHERITED FROM: increased granulocyte number || abnormal CD4-positive, alpha beta T cell number || abnormal CD8-positive, alpha-beta T cell number || abnormal alpha-beta T cell number || abnormal neutrophil cell number || increased neutrophil cell number |
50729,55550 50729 - PH domain-like 55550 - SH2 domain | 0.4235 | INHERITED FROM: abnormal B cell number || decreased B cell number || abnormal neutrophil cell number || increased neutrophil cell number || increased lymphocyte cell number |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.4235 | INHERITED FROM: abnormal CD4-positive, alpha beta T cell number || abnormal CD8-positive, alpha-beta T cell number || increased neutrophil cell number |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.4395 | INHERITED FROM: decreased DN2 thymocyte number |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.5774 | INHERITED FROM: decreased hematopoietic stem cell number || decreased myeloid cell number || decreased erythrocyte cell number |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57424,50494 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases | 0 | Direct |
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like | 0 | Direct |
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | Direct |
49562,51045 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 51045 - WW domain | 0 | Direct |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | Direct |
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) | 0 | Direct |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0.000139 | Direct |
47986,47986 47986 - DEATH domain 47986 - DEATH domain | 0.00109 | Inherited |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.001455 | Inherited |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0.004155 | Inherited |
57944,56436 57944 - Triple coiled coil domain of C-type lectins 56436 - C-type lectin-like | 0.01215 | Inherited |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0.02898 | Inherited |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0.08899 | Inherited |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.1193 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1319 | Inherited |
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like | 0.1498 | Inherited |
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like | 0.1634 | Inherited |
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.1781 | Inherited |
69179,69179 69179 - Integrin domains 69179 - Integrin domains | 0.1781 | Inherited |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.2098 | Inherited |
47454,57959 47454 - A DNA-binding domain in eukaryotic transcription factors 57959 - Leucine zipper domain | 0.2995 | Inherited |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0.3132 | Inherited |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.4232 | Inherited |
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain | 0.4235 | Inherited |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0.4235 | Inherited |
50729,55550 50729 - PH domain-like 55550 - SH2 domain | 0.4235 | Inherited |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.4235 | Inherited |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.4395 | Inherited |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.5774 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain | 0 | DIRECT |
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | DIRECT |
57424,57424,50494 57424 - LDL receptor-like module 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases | 0 | DIRECT |
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain | 0 | DIRECT |
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | DIRECT |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.00282 | INHERITED FROM: decreased leukocyte cell number || decreased hematopoietic cell number |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.07392 | INHERITED FROM: decreased leukocyte cell number |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1112 | INHERITED FROM: absent mast cells |
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains | 0.1781 | INHERITED FROM: decreased T cell number |
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.4235 | INHERITED FROM: increased CD8-positive, alpha-beta T cell number || increased alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.4235 | INHERITED FROM: increased granulocyte number || abnormal CD4-positive, alpha beta T cell number || abnormal CD8-positive, alpha-beta T cell number || abnormal alpha-beta T cell number || abnormal neutrophil cell number || increased neutrophil cell number |
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0.5036 | INHERITED FROM: decreased T cell number || abnormal B cell number || decreased B cell number || increased lymphocyte cell number |
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.5036 | INHERITED FROM: decreased T cell number || abnormal B cell number || decreased B cell number || increased lymphocyte cell number |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain | 0 | Direct |
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | Direct |
57424,57424,50494 57424 - LDL receptor-like module 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases | 0 | Direct |
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain | 0 | Direct |
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | Direct |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.00282 | Inherited |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.07392 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1112 | Inherited |
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains | 0.1781 | Inherited |
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.4235 | Inherited |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.4235 | Inherited |
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0.5036 | Inherited |
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.5036 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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