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Mammalian Phenotype (MP): abnormal organ/body region tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + 2:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
0:   abnormal organ/body region tumor incidence [MP:0013152] <2>(21|24) (24|8|3)
- 1:   decreased organ/body region tumor incidence [MP:0010282] <15>(0|0) (0|0|0)
- 1:   increased organ/body region tumor incidence [MP:0010274] <14>(21|24) (24|8|3)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000003989Direct
Nucleic acid-binding proteins0.0002015Direct
SMAD/FHA domain0.0003335Direct
SPOC domain-like0.0006213Direct
DNA-glycosylase0.0006213Direct
Cyclin-like0.001079Inherited
Notch domain0.002093Inherited
DNA repair protein MutS, domain III0.002093Inherited
SAND domain-like0.002093Inherited
Putative DNA-binding domain0.008496Inherited
BRCT domain0.009356Inherited
RING/U-box0.04506Inherited
CCCH zinc finger0.0461Inherited
SET domain0.05596Inherited
ARM repeat0.09629Inherited
Protein kinase-like (PK-like)0.1434Inherited
p53-like transcription factors0.2724Inherited
4-helical cytokines0.4185Inherited
Intermediate filament protein, coiled coil region0.529Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6932Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.000002896Direct
SMAD MH1 domain0.000002896Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.000002896Direct
DNA polymerase I0.0002124Direct
Pointed domain0.0005751Direct
L domain0.0005751Direct
Notch domain0.001539Inherited
DNA repair protein MutS, domain III0.001539Inherited
p120GAP domain-like0.003747Inherited
Single strand DNA-binding domain, SSB0.006644Inherited
Short-chain cytokines0.0115Inherited
Histone lysine methyltransferases0.01952Inherited
CCCH zinc finger0.03932Inherited
FHA domain0.0618Inherited
Protein kinases, catalytic subunit0.1307Inherited
Phosphotyrosine-binding domain (PTB)0.2851Inherited
ABC transporter ATPase domain-like0.2952Inherited
DnaQ-like 3'-5' exonuclease0.4873Inherited
Intermediate filament protein, coiled coil region0.4877Inherited
Forkhead DNA-binding domain0.4878Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.8106Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.0000017Direct
Nucleic acid-binding proteins0.000102Direct
SMAD/FHA domain0.0001732Direct
SPOC domain-like0.0003303Direct
DNA-glycosylase0.0003303Direct
Cyclin-like0.0005921Direct
Notch domain0.001192Inherited
DNA repair protein MutS, domain III0.001192Inherited
SAND domain-like0.001192Inherited
Putative DNA-binding domain0.005249Inherited
BRCT domain0.005818Inherited
RING/U-box0.0316Inherited
CCCH zinc finger0.03241Inherited
SET domain0.03995Inherited
ARM repeat0.07235Inherited
Protein kinase-like (PK-like)0.1129Inherited
p53-like transcription factors0.2306Inherited
DNA/RNA polymerases0.2775Inherited
4-helical cytokines0.3716Inherited
Intermediate filament protein, coiled coil region0.4818Inherited
Leucine zipper domain0.5467Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.652Inherited
Cysteine-rich domain0.7513Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0003303Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000424Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.000424Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001192Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.008878Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.06659Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.4818Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003303Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000424Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04092Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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