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Mammalian Phenotype (MP): increased leukocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + 4:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + 3:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + 3:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + 2:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
+ + 2:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ 1:   increased hematopoietic cell number [MP:0011181] <4>(12|26) (19|11|7)
+ 1:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
0:   increased leukocyte cell number [MP:0000218] <5>(9|23) (15|11|7)
- 1:   increased granulocyte number [MP:0000322] <4>(0|4) (0|4|1)
- 1:   increased lymphocyte cell number [MP:0005013] <4>(3|12) (8|6|6)
- 1:   increased macrophage cell number [MP:0005425] <2>(4|4) (4|0|0)
- 1:   increased monocyte cell number [MP:0000220] <2>(0|0) (0|0|0)
- 1:   increased plasmacytoid dendritic cell number [MP:0008524](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
L30e-like0.00009772Direct
p53-like transcription factors0.0004378Direct
Flavoproteins0.0004973Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1231Inherited
Riboflavin synthase domain-like0.1231Inherited
DBL homology domain (DH-domain)0.1575Inherited
Toll/Interleukin receptor TIR domain0.4591Inherited
Calponin-homology domain, CH-domain0.6734Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.0000000008066Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000001787Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00001288Direct
Interferon regulatory factor0.002072Inherited
Tissue inhibitor of metalloproteinases, TIMP0.002166Inherited
Cytochrome p450 reductase N-terminal domain-like0.002166Inherited
SH2 domain0.004397Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.007213Inherited
NADPH-cytochrome p450 reductase-like0.007213Inherited
Nuclear receptor coactivator interlocking domain0.007213Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.02708Inherited
DEATH domain, DD0.04434Inherited
Short-chain cytokines0.1149Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.1338Inherited
DBL homology domain (DH-domain)0.1343Inherited
CCCH zinc finger0.1665Inherited
Bcl-2 inhibitors of programmed cell death0.1665Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.2384Inherited
Interleukin-1 (IL-1)0.2384Inherited
Toll/Interleukin receptor TIR domain0.2851Inherited
Calponin-homology domain, CH-domain0.6472Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
L30e-like0.00004717Direct
p53-like transcription factors0.0002295Direct
Flavoproteins0.0002625Direct
NAD kinase/diacylglycerol kinase-like0.0008584Direct
TNF receptor-like0.001998Inherited
SH2 domain0.003493Inherited
Nuclear receptor coactivator interlocking domain0.00629Inherited
Riboflavin synthase domain-like0.09513Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.09513Inherited
DBL homology domain (DH-domain)0.1253Inherited
CCCH zinc finger0.1583Inherited
Bcl-2 inhibitors of programmed cell death0.1583Inherited
Toll/Interleukin receptor TIR domain0.4112Inherited
Calponin-homology domain, CH-domain0.6313Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00000002582Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000001217Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00005289Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0001601Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.001327Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.006789Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1253Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.2293Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2293Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.001871Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.001871Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.006789Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2293Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)