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Mammalian Phenotype (MP): abnormal cell death

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   cellular phenotype [MP:0005384] <6>(95|116) (103|56|31)
+ 1:   abnormal cell physiology [MP:0005621] <24>(77|96) (84|46|25)
0:   abnormal cell death [MP:0000313] <5>(29|41) (33|15|5)
- 1:   abnormal apoptosis [MP:0001648] <30>(27|38) (30|13|5)
- 1:   abnormal induced cell death [MP:0008942] <2>(5|6) (6|3|0)
- 1:   decreased cell death [MP:0012555] <1>(4|5) (5|3|1)
- 1:   increased cell death [MP:0012556] <1>(16|23) (18|7|3)
- 1:   cellular necrosis [MP:0000316](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SRF-like0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Tubby C-terminal domain-like0Direct
The spindle assembly checkpoint protein mad20Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Caspase-like0.000001155Direct
DEATH domain0.0009662Direct
Bcl-2 inhibitors of programmed cell death0.001391Inherited
STAT0.001816Inherited
Transcription factor STAT-4 N-domain0.001816Inherited
p53-like transcription factors0.005861Inherited
Cullin repeat-like0.006561Inherited
Rhodanese/Cell cycle control phosphatase0.02134Inherited
BRCT domain0.04851Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.05305Inherited
Riboflavin synthase domain-like0.05305Inherited
Ran binding protein zinc finger-like0.08184Inherited
DHS-like NAD/FAD-binding domain0.08865Inherited
Flavoproteins0.08865Inherited
Leucine zipper domain0.1069Inherited
PYP-like sensor domain (PAS domain)0.1197Inherited
SH2 domain0.1841Inherited
Cystine-knot cytokines0.2296Inherited
Arginase/deacetylase0.2575Inherited
Cyclin-like0.5757Inherited
Thioredoxin-like0.5972Inherited
Nucleic acid-binding proteins0.7017Inherited
Fibronectin type III1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Transcriptional factor tubby, C-terminal domain0Direct
U-box0Direct
Cullin repeat0Direct
Retinoblastoma tumor suppressor domains0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
The spindle assembly checkpoint protein mad20Direct
SRF-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Caspase catalytic domain0.00000008453Direct
Caspase recruitment domain, CARD0.000615Direct
Bcl-2 inhibitors of programmed cell death0.0009728Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001261Inherited
NADPH-cytochrome p450 reductase-like0.001261Inherited
STAT DNA-binding domain0.001262Inherited
STAT0.001262Inherited
Transcription factor STAT-4 N-domain0.001262Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00213Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.003939Inherited
Cell cycle control phosphatase, catalytic domain0.00457Inherited
Ran binding protein zinc finger-like0.06448Inherited
SCF ubiquitin ligase complex WHB domain0.06986Inherited
Sir2 family of transcriptional regulators0.06986Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.07187Inherited
Leucine zipper domain0.08777Inherited
Extracellular domain of cell surface receptors0.09796Inherited
Tudor domain0.1191Inherited
Histone deacetylase, HDAC0.1553Inherited
SH2 domain0.1595Inherited
Single strand DNA-binding domain, SSB0.1762Inherited
FHA domain0.2362Inherited
Toll/Interleukin receptor TIR domain0.3245Inherited
Glutathione peroxidase-like0.3391Inherited
ets domain0.3491Inherited
Transforming growth factor (TGF)-beta0.3563Inherited
WW domain0.6339Inherited
HLH, helix-loop-helix DNA-binding domain0.7459Inherited
I set domains0.8711Inherited
Fibronectin type III1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
The spindle assembly checkpoint protein mad20Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Tubby C-terminal domain-like0Direct
p53 tetramerization domain0Direct
SRF-like0Direct
Caspase-like0.0000004713Direct
DEATH domain0.0005262Direct
Bcl-2 inhibitors of programmed cell death0.0007765Direct
Protein kinase-like (PK-like)0.0009754Direct
STAT0.001028Inherited
Transcription factor STAT-4 N-domain0.001028Inherited
p53-like transcription factors0.003534Inherited
Cullin repeat-like0.003997Inherited
Rhodanese/Cell cycle control phosphatase0.01407Inherited
BRCT domain0.03417Inherited
Riboflavin synthase domain-like0.03762Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.03762Inherited
Ran binding protein zinc finger-like0.06055Inherited
DHS-like NAD/FAD-binding domain0.06619Inherited
Flavoproteins0.06619Inherited
Leucine zipper domain0.08135Inherited
PYP-like sensor domain (PAS domain)0.09227Inherited
SH2 domain0.1489Inherited
Cystine-knot cytokines0.1908Inherited
Arginase/deacetylase0.2167Inherited
Cyclin-like0.5293Inherited
Thioredoxin-like0.5516Inherited
WW domain0.6215Inherited
Nucleic acid-binding proteins0.6608Inherited
HLH, helix-loop-helix DNA-binding domain0.7302Inherited
Immunoglobulin0.9974Inherited
Fibronectin type III1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0002277Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001028Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.001028Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001028Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.003553Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.03762Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.06619Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06771Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1333Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1386Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9806Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001028Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001028Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.07772Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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