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Mammalian Phenotype (MP): abnormal cell proliferation

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   cellular phenotype [MP:0005384] <6>(95|116) (103|56|31)
+ 1:   abnormal cell physiology [MP:0005621] <24>(77|96) (84|46|25)
0:   abnormal cell proliferation [MP:0000350] <31>(15|19) (18|11|5)
- 1:   decreased cell proliferation [MP:0000352] <21>(7|10) (9|6|3)
- 1:   increased cell proliferation [MP:0000351] <20>(1|0) (1|1|0)
- 1:   abnormal neural crest cell proliferation [MP:0009842] <4>(0|0) (0|0|0)
- 1:   abnormal inner cell mass proliferation [MP:0004966] <3>(0|0) (0|0|0)
- 1:   abnormal trophectoderm cell proliferation [MP:0012115] <3>(0|0) (0|0|0)
- 1:   abnormal CD8-positive, alpha-beta memory T cell proliferation [MP:0011821] <2>(0|0) (0|0|0)
- 1:   abnormal Schwann cell proliferation [MP:0011905] <2>(0|0) (0|0|0)
- 1:   abnormal chondrocyte proliferation [MP:0014099] <2>(0|0) (0|0|0)
- 1:   abnormal endothelial cell proliferation [MP:0012202] <2>(0|0) (0|0|0)
- 1:   abnormal fetal cardiomyocyte proliferation [MP:0003567] <2>(0|1) (0|0|0)
- 1:   abnormal fibroblast proliferation [MP:0011702] <2>(2|1) (2|0|0)
- 1:   abnormal hematopoietic stem cell proliferation [MP:0011901] <2>(0|0) (0|0|0)
- 1:   abnormal keratinocyte proliferation [MP:0009582] <2>(1|1) (1|0|0)
- 1:   abnormal kidney cell proliferation [MP:0011439] <2>(1|1) (1|1|1)
- 1:   abnormal lung endothelial cell proliferation [MP:0011138] <2>(0|0) (0|0|0)
- 1:   abnormal macrophage proliferation [MP:0011985] <2>(0|0) (0|0|0)
- 1:   abnormal mesenchymal cell proliferation involved in lung development [MP:0011146] <2>(0|1) (1|0|0)
- 1:   abnormal neuron proliferation [MP:0009967] <2>(1|1) (2|0|1)
- 1:   abnormal pancreatic beta cell proliferation [MP:0011818] <2>(0|0) (0|0|0)
- 1:   abnormal pancreatic endocrine progenitor cell proliferation [MP:0011908] <2>(0|0) (0|0|0)
- 1:   abnormal splenocyte proliferation [MP:0009334] <2>(1|1) (1|0|0)
- 1:   abnormal vascular endothelial cell proliferation [MP:0020146] <2>(0|0) (0|0|0)
- 1:   abnormal enterocyte proliferation [MP:0008883](0|0) (0|0|0)
- 1:   abnormal epidermal stem cell proliferation [MP:0011006](0|0) (0|0|0)
- 1:   abnormal melanocyte proliferation [MP:0010741](0|0) (0|0|0)
- 1:   abnormal organ of Corti supporting cell proliferation [MP:0008306](0|0) (0|0|0)
- 1:   abnormal primordial germ cell proliferation [MP:0008390](0|0) (0|0|0)
- 1:   abnormal skeletal muscle satellite cell proliferation [MP:0009410](1|1) (1|0|0)
- 1:   abnormal small intestinal crypt cell proliferation [MP:0010157](1|1) (1|0|0)
- 1:   abnormal spermatogonia proliferation [MP:0002685](0|0) (0|0|0)
- 1:   abnormal trophoblast giant cell proliferation [MP:0010039](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Lamin A/C globular tail domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Putative DNA-binding domain0.0003053Direct
SAND domain-like0.0004058Direct
STAT0.02374Inherited
Transcription factor STAT-4 N-domain0.02374Inherited
Nucleic acid-binding proteins0.02966Inherited
E2F-DP heterodimerization region0.06683Inherited
Cyclin-like0.1007Inherited
Toll/Interleukin receptor TIR domain0.1756Inherited
HLH, helix-loop-helix DNA-binding domain0.2225Inherited
Rhodanese/Cell cycle control phosphatase0.3084Inherited
Growth factor receptor domain0.8156Inherited
Integrin domains0.8715Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
SMAD4-binding domain of oncoprotein Ski0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
ATP-dependent DNA ligase catalytic domain0Direct
Lamin A/C globular tail domain0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01473Inherited
STAT DNA-binding domain0.01773Inherited
STAT0.01773Inherited
Transcription factor STAT-4 N-domain0.01773Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.0257Inherited
E2F dimerization segment0.05344Inherited
Erythroid transcription factor GATA-10.106Inherited
Cell cycle transcription factor e2f-dp0.1711Inherited
Cell cycle control phosphatase, catalytic domain0.1891Inherited
HLH, helix-loop-helix DNA-binding domain0.2107Inherited
Toll/Interleukin receptor TIR domain0.244Inherited
Forkhead DNA-binding domain0.3861Inherited
I set domains0.807Inherited
Integrin domains0.8598Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Putative DNA-binding domain0.0001571Direct
SAND domain-like0.0002124Direct
STAT0.01579Inherited
Transcription factor STAT-4 N-domain0.01579Inherited
Nucleic acid-binding proteins0.02016Inherited
E2F-DP heterodimerization region0.04861Inherited
Cyclin-like0.07604Inherited
Homeodomain-like0.1333Inherited
Toll/Interleukin receptor TIR domain0.1412Inherited
Acyl-CoA N-acyltransferases (Nat)0.153Inherited
HLH, helix-loop-helix DNA-binding domain0.1841Inherited
Rhodanese/Cell cycle control phosphatase0.2646Inherited
"Winged helix" DNA-binding domain0.2815Inherited
Growth factor receptor domain0.7817Inherited
Integrin domains0.8422Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01579Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01579Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01579Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.03767Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.04861Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.09929Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8291Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01579Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01579Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.2531Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3684Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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