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Mammalian Phenotype (MP): decreased cell proliferation

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   cellular phenotype [MP:0005384] <6>(95|116) (103|56|31)
+ + 2:   abnormal cell physiology [MP:0005621] <24>(77|96) (84|46|25)
+ 1:   abnormal cell proliferation [MP:0000350] <31>(15|19) (18|11|5)
0:   decreased cell proliferation [MP:0000352] <21>(7|10) (9|6|3)
- 1:   decreased fibroblast proliferation [MP:0011704] <3>(1|1) (1|0|0)
- 1:   decreased CD8-positive, alpha-beta memory T cell proliferation [MP:0011823](0|0) (0|0|0)
- 1:   decreased Schwann cell proliferation [MP:0011907](0|0) (0|0|0)
- 1:   decreased cerebellar granule cell precursor proliferation [MP:0013551](0|0) (0|0|0)
- 1:   decreased chondrocyte proliferation [MP:0014101](0|0) (0|0|0)
- 1:   decreased embryonic epiblast cell proliferation [MP:0011192](0|0) (0|0|0)
- 1:   decreased endothelial cell proliferation [MP:0012201](0|0) (0|0|0)
- 1:   decreased fetal cardiomyocyte proliferation [MP:0011395](0|0) (0|0|0)
- 1:   decreased hematopoietic stem cell proliferation [MP:0011903](0|0) (0|0|0)
- 1:   decreased hepatocyte proliferation [MP:0004001](0|0) (0|0|0)
- 1:   decreased inner cell mass proliferation [MP:0012113](0|0) (0|0|0)
- 1:   decreased keratinocyte proliferation [MP:0009584](1|1) (1|0|0)
- 1:   decreased kidney cell proliferation [MP:0011441](1|1) (1|1|1)
- 1:   decreased lung endothelial cell proliferation [MP:0011140](0|0) (0|0|0)
- 1:   decreased macrophage proliferation [MP:0011986](0|0) (0|0|0)
- 1:   decreased mammary gland epithelial cell proliferation [MP:0010174](0|0) (0|0|0)
- 1:   decreased mesenchymal cell proliferation involved in lung development [MP:0011148](0|1) (1|0|0)
- 1:   decreased otic epithelial cell proliferation [MP:0008064](0|0) (0|0|0)
- 1:   decreased pancreatic endocrine progenitor cell proliferation [MP:0011910](0|0) (0|0|0)
- 1:   decreased splenocyte proliferation [MP:0009335](1|0) (1|0|0)
- 1:   decreased trophectoderm cell proliferation [MP:0012117](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0.0003412Direct
Transcription factor STAT-4 N-domain0.0003412Direct
E2F-DP heterodimerization region0.0003412Direct
Nucleic acid-binding proteins0.006027Inherited
Integrin domains0.06478Inherited
Growth factor receptor domain0.3988Inherited
Toll/Interleukin receptor TIR domain0.4002Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Phoshoinositide 3-kinase (PI3K), catalytic domain0.000004719Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.0000266Direct
E2F dimerization segment0.00008303Direct
STAT DNA-binding domain0.0002318Direct
STAT0.0002318Direct
Transcription factor STAT-4 N-domain0.0002318Direct
Cell cycle transcription factor e2f-dp0.000949Direct
Integrin domains0.05574Inherited
Forkhead DNA-binding domain0.4211Inherited
I set domains0.6999Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
E2F-DP heterodimerization region0.0001772Direct
STAT0.0001772Direct
Transcription factor STAT-4 N-domain0.0001772Direct
Acyl-CoA N-acyltransferases (Nat)0.0006557Direct
Nucleic acid-binding proteins0.003642Inherited
Integrin domains0.047Inherited
Growth factor receptor domain0.3522Inherited
Toll/Interleukin receptor TIR domain0.3535Inherited
"Winged helix" DNA-binding domain0.5228Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001772Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0001772Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0001772Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001772Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.0006046Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9309Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001772Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001772Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9369Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)