SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal craniofacial morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   craniofacial phenotype [MP:0005382] <1>(20|36) (24|17|10)
0:   abnormal craniofacial morphology [MP:0000428] <5>(20|36) (24|17|10)
- 1:   abnormal outer ear morphology [MP:0002177] <19>(0|1) (1|1|0)
- 1:   abnormal craniofacial development [MP:0003935] <17>(3|3) (5|3|2)
- 1:   abnormal facial morphology [MP:0003743] <10>(8|18) (8|3|2)
- 1:   abnormal head shape [MP:0011495] <7>(1|0) (1|0|0)
- 1:   abnormal craniofacial bone morphology [MP:0002116] <3>(16|25) (16|13|7)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Homeodomain-like0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.000002246Direct
p53-like transcription factors0.000009644Direct
Growth factor receptor domain0.0001025Direct
Cystine-knot cytokines0.0001029Direct
EGF/Laminin0.00121Inherited
FnI-like domain0.004565Inherited
Intermediate filament protein, coiled coil region0.005048Inherited
TB module/8-cys domain0.009972Inherited
Bromodomain0.0332Inherited
Metalloproteases ("zincins"), catalytic domain0.03885Inherited
PGBD-like0.06826Inherited
Nuclear receptor ligand-binding domain0.0849Inherited
Hemopexin-like domain0.1136Inherited
lambda repressor-like DNA-binding domains0.168Inherited
(Trans)glycosidases0.1869Inherited
Transducin (alpha subunit), insertion domain0.2277Inherited
4-helical cytokines0.3211Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
Homeodomain0.000000000000007866Direct
SMAD MH1 domain0.000001515Direct
SMAD domain0.000001515Direct
Paired domain0.00001012Direct
Forkhead DNA-binding domain0.0001687Direct
T-box0.0007526Direct
Transforming growth factor (TGF)-beta0.0008568Direct
CalX-beta domain0.0008875Direct
Growth factor receptor domain0.001216Inherited
Arylsulfatase0.001992Inherited
Multidrug efflux transporter AcrB transmembrane domain0.002108Inherited
TNF receptor-like0.002492Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.003838Inherited
Intermediate filament protein, coiled coil region0.004458Inherited
Laminin-type module0.005517Inherited
TB module/8-cys domain0.007693Inherited
Pyridoxal-dependent decarboxylase0.01514Inherited
VWC domain0.01518Inherited
Extracellular domain of cell surface receptors0.02062Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02134Inherited
Ephrin ectodomain0.02649Inherited
Neutral endopeptidase (neprilysin)0.02649Inherited
Bromodomain0.02913Inherited
MMP N-terminal domain0.0596Inherited
I set domains0.06263Inherited
Nuclear receptor0.06395Inherited
Matrix metalloproteases, catalytic domain0.0728Inherited
Nuclear receptor ligand-binding domain0.07995Inherited
Hemopexin-like domain0.1029Inherited
DEATH domain, DD0.1265Inherited
Transducin (alpha subunit), insertion domain0.2109Inherited
G proteins0.4125Inherited
Rhodopsin-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.000000934Direct
p53-like transcription factors0.000004225Direct
Growth factor receptor domain0.00004961Direct
Cystine-knot cytokines0.0000499Direct
EGF/Laminin0.0006677Direct
CalX-like0.0006817Direct
Protein kinase-like (PK-like)0.0008232Direct
FnI-like domain0.002713Inherited
Intermediate filament protein, coiled coil region0.003023Inherited
TB module/8-cys domain0.006227Inherited
Orange domain-like0.02266Inherited
Bromodomain0.02272Inherited
Metalloproteases ("zincins"), catalytic domain0.02689Inherited
PGBD-like0.04979Inherited
Nuclear receptor ligand-binding domain0.06303Inherited
Snake toxin-like0.06509Inherited
Hemopexin-like domain0.08714Inherited
lambda repressor-like DNA-binding domains0.1343Inherited
(Trans)glycosidases0.1514Inherited
Transducin (alpha subunit), insertion domain0.189Inherited
4-helical cytokines0.277Inherited
Family A G protein-coupled receptor-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0004168Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0005358Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001207Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.001727Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001963Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.002996Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.003093Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.008195Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01267Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.01267Inherited
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.01267Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.02266Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.03259Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.04979Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.07346Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.162Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00007413Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0005418Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001207Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002433Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003093Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.00585Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00585Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01267Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.02242Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03539Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)