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Mammalian Phenotype (MP): abnormal cranium morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
+ + + 3:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
+ + + 3:   craniofacial phenotype [MP:0005382] <1>(20|36) (24|17|10)
+ + 2:   abnormal craniofacial morphology [MP:0000428] <5>(20|36) (24|17|10)
+ + 2:   abnormal axial skeleton morphology [MP:0002114] <4>(24|40) (25|21|14)
+ 1:   abnormal craniofacial bone morphology [MP:0002116] <3>(16|25) (16|13|7)
0:   abnormal cranium morphology [MP:0000438] <11>(16|25) (16|13|7)
- 1:   abnormal neurocranium morphology [MP:0000074] <11>(5|5) (5|3|0)
- 1:   abnormal viscerocranium morphology [MP:0005274] <11>(7|16) (7|7|7)
- 1:   abnormal cranium size [MP:0010031] <8>(1|0) (1|0|0)
- 1:   abnormal cranial suture morphology [MP:0002835] <7>(0|0) (0|0|0)
- 1:   abnormal basicranium morphology [MP:0010029] <3>(2|2) (2|1|0)
- 1:   abnormal orbit morphology [MP:0010030] <3>(0|0) (0|0|0)
- 1:   acrania [MP:0003104](0|0) (0|0|0)
- 1:   cranioschisis [MP:0000919](0|0) (0|0|0)
- 1:   domed cranium [MP:0000440](1|2) (1|1|0)
- 1:   ectopic cranial bone [MP:0014166](0|0) (0|0|0)
- 1:   malocclusion [MP:0000120](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Growth factor receptor domain0.000008704Direct
p53-like transcription factors0.00001425Direct
EGF/Laminin0.0001853Direct
FnI-like domain0.0009334Direct
TB module/8-cys domain0.00175Inherited
PGBD-like0.01283Inherited
Metalloproteases ("zincins"), catalytic domain0.02375Inherited
Hemopexin-like domain0.02416Inherited
Transducin (alpha subunit), insertion domain0.08603Inherited
lambda repressor-like DNA-binding domains0.1056Inherited
Nuclear receptor ligand-binding domain0.164Inherited
4-helical cytokines0.1684Inherited
Bromodomain0.1693Inherited
Homeodomain-like0.8118Inherited
Cystine-knot cytokines0.9958Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Transforming growth factor (TGF)-beta0.00003948Direct
Growth factor receptor domain0.00009721Direct
Arylsulfatase0.0002075Direct
Laminin-type module0.0003549Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0004241Direct
Forkhead DNA-binding domain0.0006544Direct
TB module/8-cys domain0.001253Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.003016Inherited
TNF receptor-like0.005908Inherited
Neutral endopeptidase (neprilysin)0.006761Inherited
MMP N-terminal domain0.01028Inherited
Matrix metalloproteases, catalytic domain0.01301Inherited
Hemopexin-like domain0.01995Inherited
Extracellular domain of cell surface receptors0.02315Inherited
T-box0.03143Inherited
DEATH domain, DD0.05959Inherited
Transducin (alpha subunit), insertion domain0.07353Inherited
Nuclear receptor0.1339Inherited
Nuclear receptor ligand-binding domain0.1534Inherited
Bromodomain0.155Inherited
G proteins0.2511Inherited
Homeodomain0.4925Inherited
Paired domain0.9232Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Growth factor receptor domain0.000003792Direct
p53-like transcription factors0.000006318Direct
EGF/Laminin0.00009337Direct
FnI-like domain0.000507Direct
TB module/8-cys domain0.0009891Direct
PGBD-like0.008158Inherited
Metalloproteases ("zincins"), catalytic domain0.0158Inherited
Hemopexin-like domain0.01609Inherited
Transducin (alpha subunit), insertion domain0.06399Inherited
lambda repressor-like DNA-binding domains0.08023Inherited
Nuclear receptor ligand-binding domain0.131Inherited
4-helical cytokines0.1347Inherited
Bromodomain0.1355Inherited
Homeodomain-like0.7777Inherited
Cystine-knot cytokines0.9817Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0001681Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0003216Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0004111Direct
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.0004621Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.001138Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.002998Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.002998Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.008001Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.008158Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.02679Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.04593Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05311Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0001681Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0005842Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.001277Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001277Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001557Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.009219Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.08023Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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