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Mammalian Phenotype (MP): abnormal liver morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   liver/biliary system phenotype [MP:0005370] <2>(37|39) (41|19|10)
+ 1:   abnormal hepatobiliary system morphology [MP:0002138] <6>(25|32) (28|15|5)
0:   abnormal liver morphology [MP:0000598] <26>(23|28) (26|13|5)
- 1:   abnormal intrahepatic bile duct morphology [MP:0009497] <3>(0|0) (0|0|0)
- 1:   abnormal liver parenchyma morphology [MP:0008986] <3>(2|2) (2|2|0)
- 1:   abnormal liver size [MP:0004848] <3>(3|7) (4|4|2)
- 1:   abnormal liver vasculature morphology [MP:0009820] <3>(4|4) (4|0|0)
- 1:   hepatic necrosis [MP:0001654] <3>(1|2) (1|0|0)
- 1:   abnormal liver cholesterol level [MP:0012776] <2>(1|0) (1|0|0)
- 1:   abnormal liver copper level [MP:0003065] <2>(1|1) (1|0|0)
- 1:   abnormal liver development [MP:0000596] <2>(1|1) (1|0|0)
- 1:   abnormal liver glycogen level [MP:0012777] <2>(0|1) (1|0|0)
- 1:   abnormal liver iron level [MP:0008738] <2>(0|0) (0|0|0)
- 1:   abnormal liver triglyceride level [MP:0012778] <2>(2|2) (2|2|1)
- 1:   abnormal hepatic cord morphology [MP:0012246](0|0) (0|0|0)
- 1:   abnormal liver zinc level [MP:0011924](0|0) (0|0|0)
- 1:   absent liver [MP:0011877](0|0) (0|0|0)
- 1:   decreased liver free fatty acids level [MP:0010360](0|0) (0|0|0)
- 1:   decreased susceptibility to hepatic steatosis [MP:0002310](0|0) (0|0|0)
- 1:   hepatic steatosis [MP:0002628](3|3) (3|1|0)
- 1:   herniated liver [MP:0010912](0|0) (0|0|0)
- 1:   increased liver free fatty acids level [MP:0010359](0|0) (0|0|0)
- 1:   liver abscess [MP:0003332](0|0) (0|0|0)
- 1:   liver cirrhosis [MP:0003046](0|0) (0|0|0)
- 1:   liver cysts [MP:0003327](0|0) (0|0|0)
- 1:   liver degeneration [MP:0003103](0|0) (0|0|0)
- 1:   liver fibrosis [MP:0003333](1|2) (2|1|0)
- 1:   liver hemorrhage [MP:0003888](0|0) (0|0|0)
- 1:   pale liver [MP:0000603](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Thioesterase/thiol ester dehydrase-isomerase0Direct
Hairpin loop containing domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
(Trans)glycosidases0.000002505Direct
Nuclear receptor ligand-binding domain0.000003349Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0002106Direct
Acyl-CoA dehydrogenase NM domain-like0.0002106Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002535Direct
STAT0.0003555Direct
Transcription factor STAT-4 N-domain0.0003555Direct
Flavoproteins0.0003555Direct
Families 57/38 glycoside transferase middle domain0.000465Direct
HMA, heavy metal-associated domain0.002583Inherited
Multidrug efflux transporter AcrB transmembrane domain0.008507Inherited
ABC transporter transmembrane region0.0172Inherited
Alpha-macroglobulin receptor domain0.02941Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.03158Inherited
Riboflavin synthase domain-like0.03158Inherited
A DNA-binding domain in eukaryotic transcription factors0.1054Inherited
YWTD domain0.1823Inherited
Trypsin-like serine proteases0.2904Inherited
Homeodomain-like0.6613Inherited
DHS-like NAD/FAD-binding domain0.7862Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nuclear receptor ligand-binding domain0.000002614Direct
Nuclear receptor0.000005823Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0002313Direct
STAT DNA-binding domain0.0002313Direct
STAT0.0002313Direct
Transcription factor STAT-4 N-domain0.0002313Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0002313Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0002981Direct
alpha-mannosidase, domain 20.0002981Direct
NADPH-cytochrome p450 reductase-like0.0002981Direct
alpha-mannosidase0.0002981Direct
Fatty acid binding protein-like0.001113Inherited
HMA, heavy metal-associated domain0.001749Inherited
Erythroid transcription factor GATA-10.00622Inherited
Kringle modules0.01711Inherited
ABC transporter transmembrane region0.02045Inherited
Complement components0.02265Inherited
Alpha-macroglobulin receptor domain0.02265Inherited
A DNA-binding domain in eukaryotic transcription factors0.09014Inherited
YWTD domain0.1609Inherited
Chaperone J-domain0.268Inherited
Eukaryotic proteases0.3155Inherited
ABC transporter ATPase domain-like0.476Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.7131Inherited
Sir2 family of transcriptional regulators0.756Inherited
Homeodomain0.8171Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Hairpin loop containing domain-like0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
(Trans)glycosidases0.000001046Direct
Nuclear receptor ligand-binding domain0.000001418Direct
Acyl-CoA dehydrogenase NM domain-like0.0001067Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0001067Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0001294Direct
Flavoproteins0.0001849Direct
STAT0.0001849Direct
Transcription factor STAT-4 N-domain0.0001849Direct
Families 57/38 glycoside transferase middle domain0.0002443Direct
HMA, heavy metal-associated domain0.001486Inherited
Multidrug efflux transporter AcrB transmembrane domain0.005257Inherited
ABC transporter transmembrane region0.01118Inherited
Alpha-macroglobulin receptor domain0.01996Inherited
Riboflavin synthase domain-like0.02157Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02157Inherited
EGF/Laminin0.04072Inherited
Insulin-like0.04558Inherited
A DNA-binding domain in eukaryotic transcription factors0.08009Inherited
YWTD domain0.1473Inherited
Chaperone J-domain0.2436Inherited
Trypsin-like serine proteases0.2477Inherited
Homeodomain-like0.6186Inherited
DHS-like NAD/FAD-binding domain0.7506Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.000007148Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.0001067Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001849Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0001849Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001849Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0.0002443Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0005503Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01118Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02632Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.04558Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.1719Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001849Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001849Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01989Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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