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Mammalian Phenotype (MP): abnormal immune system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
0:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
- 1:   abnormal lymphatic vessel morphology [MP:0001879] <10>(1|2) (3|0|0)
- 1:   abnormal immune system organ morphology [MP:0002722] <8>(21|31) (26|15|9)
- 1:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
SH2 domain0.0008509Direct
p53-like transcription factors0.003635Inherited
L30e-like0.006553Inherited
Notch domain0.01225Inherited
Flavoproteins0.0159Inherited
TNF receptor-like0.02374Inherited
Triple coiled coil domain of C-type lectins0.03158Inherited
Nuclear receptor ligand-binding domain0.0567Inherited
CCCH zinc finger0.0829Inherited
BRCT domain0.0887Inherited
4-helical cytokines0.1144Inherited
Ran binding protein zinc finger-like0.1654Inherited
Interleukin 8-like chemokines0.1726Inherited
TIMP-like0.2024Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2026Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2862Inherited
DEATH domain0.2926Inherited
E set domains0.3596Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3721Inherited
DNA polymerase beta, N-terminal domain-like0.3721Inherited
Riboflavin synthase domain-like0.3721Inherited
E2F-DP heterodimerization region0.3721Inherited
Integrin domains0.4087Inherited
MHC antigen-recognition domain0.4087Inherited
SET domain0.4087Inherited
DNA/RNA polymerases0.4238Inherited
Ankyrin repeat0.4333Inherited
WWE domain0.4565Inherited
Terpenoid cyclases/Protein prenyltransferases0.4908Inherited
Bcl-2 inhibitors of programmed cell death0.4908Inherited
DBL homology domain (DH-domain)0.5033Inherited
Integrin alpha N-terminal domain0.6135Inherited
TNF-like0.6385Inherited
Nucleotidyltransferase0.6448Inherited
Inhibitor of apoptosis (IAP) repeat0.6448Inherited
Complement control module/SCR domain0.771Inherited
Cysteine-rich domain0.7843Inherited
SH3-domain0.7979Inherited
SMAD/FHA domain0.8127Inherited
Fibrinogen C-terminal domain-like0.9537Inherited
Homeodomain-like0.9714Inherited
Calponin-homology domain, CH-domain0.9963Inherited
Caspase-like0.9993Inherited
Toll/Interleukin receptor TIR domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
5' to 3' exonuclease, C-terminal subdomain0Direct
5' to 3' exonuclease catalytic domain0Direct
RUNT domain0Direct
STAT DNA-binding domain0Direct
BAFF receptor-like0Direct
STAT0Direct
Pyrin domain, PYD0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
DNA polymerase beta-like0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00002804Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00003784Direct
SH2 domain0.0004226Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0009093Direct
DNA polymerase I0.003101Inherited
Notch domain0.008742Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.01162Inherited
Triple coiled coil domain of C-type lectins0.02363Inherited
beta-glycanases0.02363Inherited
Tissue inhibitor of metalloproteinases, TIMP0.02363Inherited
Cytochrome p450 reductase N-terminal domain-like0.02363Inherited
TNF receptor-like0.03244Inherited
Nuclear receptor ligand-binding domain0.03982Inherited
Nuclear receptor0.03982Inherited
ets domain0.04132Inherited
C1 set domains (antibody constant domain-like)0.05975Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.06514Inherited
NADPH-cytochrome p450 reductase-like0.06514Inherited
Nuclear receptor coactivator interlocking domain0.06514Inherited
CCCH zinc finger0.0678Inherited
DEATH domain, DD0.08892Inherited
Ran binding protein zinc finger-like0.1325Inherited
Interleukin 8-like chemokines0.1372Inherited
Linker histone H1/H50.1497Inherited
Long-chain cytokines0.1665Inherited
Short-chain cytokines0.1882Inherited
Interferons/interleukin-10 (IL-10)0.2089Inherited
Pointed domain0.2613Inherited
C2 set domains0.2613Inherited
PLC-like (P variant)0.2785Inherited
Inhibitor of apoptosis (IAP) repeat0.3281Inherited
DNA polymerase beta, N-terminal domain-like0.3281Inherited
Cell cycle transcription factor e2f-dp0.3281Inherited
E2F dimerization segment0.3281Inherited
Interleukin-1 (IL-1)0.3281Inherited
Platelet-derived growth factor-like0.3281Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.3463Inherited
Pleckstrin-homology domain (PH domain)0.3507Inherited
MHC antigen-recognition domain0.3603Inherited
Integrin domains0.3603Inherited
Myb/SANT domain0.3768Inherited
Ankyrin repeat0.3779Inherited
Tetraspanin0.4112Inherited
WWE domain0.4112Inherited
Bcl-2 inhibitors of programmed cell death0.4438Inherited
DBL homology domain (DH-domain)0.4873Inherited
V set domains (antibody variable domain-like)0.5722Inherited
TNF-like0.5905Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.5905Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.6016Inherited
FHA domain0.6378Inherited
MATH domain0.6498Inherited
Interferon regulatory factor0.7196Inherited
Complement control module/SCR domain0.7309Inherited
SH3-domain0.7528Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.8589Inherited
C-type lectin domain0.8708Inherited
Fibrinogen C-terminal domain-like0.936Inherited
Calponin-homology domain, CH-domain0.9879Inherited
Caspase recruitment domain, CARD0.9974Inherited
Homeodomain1Inherited
Toll/Interleukin receptor TIR domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
SH2 domain0.0004607Direct
p53-like transcription factors0.002131Inherited
L30e-like0.003991Inherited
Notch domain0.007763Inherited
Flavoproteins0.01026Inherited
TNF receptor-like0.01579Inherited
Triple coiled coil domain of C-type lectins0.02157Inherited
NAD kinase/diacylglycerol kinase-like0.03873Inherited
Nuclear receptor ligand-binding domain0.04057Inherited
Nuclear receptor coactivator interlocking domain0.06033Inherited
CCCH zinc finger0.06139Inherited
BRCT domain0.06624Inherited
4-helical cytokines0.08778Inherited
Ran binding protein zinc finger-like0.1322Inherited
Interleukin 8-like chemokines0.1386Inherited
TIMP-like0.1655Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1657Inherited
beta-beta-alpha zinc fingers0.1747Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2438Inherited
DEATH domain0.2499Inherited
(Trans)glycosidases0.2592Inherited
E set domains0.314Inherited
Riboflavin synthase domain-like0.3262Inherited
E2F-DP heterodimerization region0.3262Inherited
DNA polymerase beta, N-terminal domain-like0.3262Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3262Inherited
SET domain0.362Inherited
MHC antigen-recognition domain0.362Inherited
Integrin domains0.362Inherited
DNA/RNA polymerases0.377Inherited
Ankyrin repeat0.3862Inherited
Protein kinase-like (PK-like)0.4029Inherited
WWE domain0.4087Inherited
Terpenoid cyclases/Protein prenyltransferases0.4431Inherited
Bcl-2 inhibitors of programmed cell death0.4431Inherited
DBL homology domain (DH-domain)0.4556Inherited
Immunoglobulin0.5387Inherited
Integrin alpha N-terminal domain0.5681Inherited
TNF-like0.5943Inherited
Nucleotidyltransferase0.6011Inherited
Inhibitor of apoptosis (IAP) repeat0.6011Inherited
vWA-like0.7309Inherited
Complement control module/SCR domain0.7338Inherited
Cysteine-rich domain0.7485Inherited
Cystine-knot cytokines0.7485Inherited
SH3-domain0.7631Inherited
SMAD/FHA domain0.7786Inherited
Acyl-CoA N-acyltransferases (Nat)0.8872Inherited
Fibrinogen C-terminal domain-like0.9326Inherited
Homeodomain-like0.9526Inherited
C-type lectin-like0.9568Inherited
Calponin-homology domain, CH-domain0.9823Inherited
Caspase-like0.9863Inherited
Toll/Interleukin receptor TIR domain0.9929Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    88723,47807
  • 88723 - PIN domain-like
  • 47807 - 5' to 3' exonuclease, C-terminal subdomain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00002966Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.002694Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.002694Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.005906Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.007578Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.009666Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01026Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01062Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.02157Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.02157Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.02545Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.06624Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1309Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1657Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.188Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.2078Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.3262Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.3262Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3908Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.4087Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.4087Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.454Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.454Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.5887Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6263Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00004613Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00896Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01026Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03213Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3262Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3262Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.4087Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4161Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.454Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5116Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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