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Mammalian Phenotype (MP): abnormal immune system cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
0:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
- 1:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
- 1:   abnormal leukopoiesis [MP:0005460] <3>(17|28) (21|18|8)
- 1:   abnormal professional antigen presenting cell morphology [MP:0008195] <3>(16|32) (20|11|5)
- 1:   abnormal follicular dendritic cell morphology [MP:0008196] <2>(0|0) (0|0|0)
- 1:   abnormal large unstained cell number [MP:0012360] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.00000001135Direct
Interleukin 8-like chemokines0.00003104Direct
L30e-like0.002408Inherited
DNA polymerase beta, N-terminal domain-like0.005941Inherited
Flavoproteins0.006978Inherited
Toll/Interleukin receptor TIR domain0.01277Inherited
BRCT domain0.01277Inherited
Terpenoid cyclases/Protein prenyltransferases0.0136Inherited
Triple coiled coil domain of C-type lectins0.01812Inherited
Ran binding protein zinc finger-like0.02144Inherited
E2F-DP heterodimerization region0.0404Inherited
SH2 domain0.05113Inherited
SH3-domain0.06462Inherited
TIMP-like0.09733Inherited
SET domain0.1204Inherited
WWE domain0.1416Inherited
Integrin domains0.1807Inherited
DEATH domain0.2177Inherited
DBL homology domain (DH-domain)0.2551Inherited
Cysteine-rich domain0.274Inherited
SMAD/FHA domain0.2747Inherited
Integrin alpha N-terminal domain0.2962Inherited
p53-like transcription factors0.3148Inherited
Nucleotidyltransferase0.3353Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.4304Inherited
Bcl-2 inhibitors of programmed cell death0.4878Inherited
Calponin-homology domain, CH-domain0.5095Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.6248Inherited
Riboflavin synthase domain-like0.6248Inherited
MHC antigen-recognition domain0.692Inherited
Nuclear receptor ligand-binding domain0.7237Inherited
DNA/RNA polymerases0.9511Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
STAT DNA-binding domain0Direct
BAFF receptor-like0Direct
STAT0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
DNA polymerase beta-like0Direct
TNF receptor-like0.00000006387Direct
Interleukin 8-like chemokines0.00002018Direct
DNA polymerase beta, N-terminal domain-like0.004073Inherited
Interleukin-1 (IL-1)0.004073Inherited
Interferons/interleukin-10 (IL-10)0.004577Inherited
Pointed domain0.004886Inherited
Triple coiled coil domain of C-type lectins0.01313Inherited
beta-glycanases0.01313Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01313Inherited
Cytochrome p450 reductase N-terminal domain-like0.01313Inherited
E2F dimerization segment0.01402Inherited
Ran binding protein zinc finger-like0.01633Inherited
V set domains (antibody variable domain-like)0.01778Inherited
Toll/Interleukin receptor TIR domain0.01884Inherited
C2 set domains0.02399Inherited
Interferon regulatory factor0.02399Inherited
Pleckstrin-homology domain (PH domain)0.02934Inherited
SH2 domain0.03781Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.03806Inherited
Tetraspanin0.03806Inherited
NADPH-cytochrome p450 reductase-like0.03806Inherited
Nuclear receptor coactivator interlocking domain0.03806Inherited
SH3-domain0.04916Inherited
Myb/SANT domain0.06502Inherited
WWE domain0.07424Inherited
Cell cycle transcription factor e2f-dp0.08632Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1192Inherited
DEATH domain, DD0.1308Inherited
Integrin domains0.1498Inherited
ets domain0.1721Inherited
Short-chain cytokines0.2261Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.2261Inherited
DBL homology domain (DH-domain)0.2352Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.2588Inherited
C1 set domains (antibody constant domain-like)0.2937Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.297Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3608Inherited
Pyrin domain, PYD0.39Inherited
Long-chain cytokines0.39Inherited
CCCH zinc finger0.4474Inherited
Bcl-2 inhibitors of programmed cell death0.4474Inherited
FHA domain0.4534Inherited
Calponin-homology domain, CH-domain0.4905Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.5123Inherited
Caspase recruitment domain, CARD0.5123Inherited
PLC-like (P variant)0.574Inherited
MHC antigen-recognition domain0.6571Inherited
Nuclear receptor ligand-binding domain0.6906Inherited
Nuclear receptor0.6906Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.7843Inherited
MATH domain0.7984Inherited
DNA polymerase I0.8553Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.000000004308Direct
Interleukin 8-like chemokines0.00001427Direct
L30e-like0.00138Inherited
Immunoglobulin0.002817Inherited
DNA polymerase beta, N-terminal domain-like0.003585Inherited
Flavoproteins0.004268Inherited
Toll/Interleukin receptor TIR domain0.008118Inherited
BRCT domain0.008118Inherited
Terpenoid cyclases/Protein prenyltransferases0.008684Inherited
TNF-like0.01122Inherited
Triple coiled coil domain of C-type lectins0.01181Inherited
Ran binding protein zinc finger-like0.01414Inherited
NAD kinase/diacylglycerol kinase-like0.01613Inherited
E2F-DP heterodimerization region0.02809Inherited
Nuclear receptor coactivator interlocking domain0.03499Inherited
SH2 domain0.03614Inherited
C-type lectin-like0.04011Inherited
SH3-domain0.04688Inherited
TIMP-like0.07324Inherited
SET domain0.09291Inherited
WWE domain0.1112Inherited
Integrin domains0.1458Inherited
(Trans)glycosidases0.1675Inherited
DEATH domain0.1796Inherited
DBL homology domain (DH-domain)0.2144Inherited
Cysteine-rich domain0.2323Inherited
SMAD/FHA domain0.2329Inherited
Integrin alpha N-terminal domain0.2531Inherited
p53-like transcription factors0.2707Inherited
Nucleotidyltransferase0.2904Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3834Inherited
beta-beta-alpha zinc fingers0.4333Inherited
CCCH zinc finger0.4401Inherited
Bcl-2 inhibitors of programmed cell death0.4401Inherited
Calponin-homology domain, CH-domain0.4619Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5259Inherited
Riboflavin synthase domain-like0.58Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.58Inherited
MHC antigen-recognition domain0.6507Inherited
Nuclear receptor ligand-binding domain0.6841Inherited
Acyl-CoA N-acyltransferases (Nat)0.7562Inherited
Protein kinase-like (PK-like)0.7754Inherited
DNA/RNA polymerases0.9297Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.00000002428Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000009058Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000002869Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00104Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00104Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00138Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.01181Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.01181Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.02809Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02947Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.0505Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1598Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1721Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2909Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.2909Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2909Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3834Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.4317Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.505Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.6335Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.6356Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.7927Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000003948Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002652Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.003585Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.01181Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.0505Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2909Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3868Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.505Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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